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Levocetirizine hydrochloride oral drops and preparation method thereof

A technology of levocetirizine hydrochloride and drops, which is applied in the direction of feeding oral medicine utensils, pharmaceutical formulas, and medical preparations with non-effective ingredients, etc., can solve the problems of inability to improve patients' medication compliance, difficulty in accurately controlling the dosage, Inconvenient to take and other problems, to achieve the effect of accurate, scientific and reasonable dosage, solving dosage and hygiene problems, and convenient administration

Inactive Publication Date: 2017-03-15
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, levocetirizine hydrochloride has been listed in the domestic and foreign dosage forms such as ordinary tablets, dispersible tablets, capsules and oral solutions, but traditional tablets and capsules are inconvenient and compliant to take for many elderly patients or children who have dysphagia. The traditional oral solution has certain advantages in clinical application, but because it is inconvenient to carry and it is difficult to accurately control the dosage, it is necessary to develop a drug that is suitable for elderly patients and children and can accurately control the dosage. Dosage, good taste and easy to carry dosage form
Patent CN101669913A discloses a levocetirizine hydrochloride granule and its preparation method. The patent uses lactose, pregelatinized starch, dextrin and other auxiliary materials as diluents, but does not involve taste-masking technology, and its preparation cannot improve patient medication compliance

Method used

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  • Levocetirizine hydrochloride oral drops and preparation method thereof
  • Levocetirizine hydrochloride oral drops and preparation method thereof
  • Levocetirizine hydrochloride oral drops and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: the preparation of oral quantitative drops of levocetirizine hydrochloride

[0026] Prescription composition:

[0027]

[0028] Preparation Process:

[0029] 1) Weigh the prescribed amount of glycerin and 40% purified water, add sodium acetate and the main ingredient in a water bath at 50°C, stir to dissolve, then add sucrose, stir to dissolve, let cool to room temperature, and obtain solution 1;

[0030] 2) Preheat the prescribed amount of propylene glycol in a water bath at 50°C, then add ethylparaben, stir to dissolve to obtain solution 2;

[0031] 3) Mix solution 1 and solution 2 evenly, add glacial acetic acid and orange essence, and then set the volume to 1000ml, and stir evenly;

[0032] 4) Filtrate, after passing the quality inspection, fill in drop bottles, screw on the bottle caps with quantitative valves, and fill each bottle with 100ml of liquid medicine.

Embodiment 2

[0033] Embodiment 2: the preparation of oral quantitative drops of levocetirizine hydrochloride

[0034] Prescription composition:

[0035]

[0036] Preparation Process:

[0037] 1) Weigh the prescribed amount of glycerin and 40% purified water, add sodium citrate and the main ingredient in a water bath at 50°C, stir to dissolve, then add sucrose and fructose, stir to dissolve, let cool to room temperature, and obtain a solution 1;

[0038] 2) Preheat the prescribed amount of propylene glycol in a water bath at 50°C, then add methylparaben, and stir to dissolve it to obtain solution 2;

[0039] 3) Mix solution 1 and solution 2 evenly, add citric acid and peach essence, make the volume to 1000ml, and stir evenly;

[0040] 4) Filtrate, after passing the quality inspection, fill in drop bottles, screw on the bottle caps with quantitative valves, and fill each bottle with 100ml of liquid medicine.

Embodiment 3

[0041] Embodiment 3: the preparation of oral quantitative drops of levocetirizine hydrochloride

[0042] Prescription composition:

[0043]

[0044] Preparation Process:

[0045] 1) Weigh the prescribed amount of glycerin and 40% purified water, add sodium citrate and the main ingredient in a water bath at 50°C, stir to dissolve, then add xylitol and stevioside, stir to dissolve, let cool to room temperature , to obtain solution 1;

[0046] 2) Weigh 20% purified water, add sodium benzoate, stir to dissolve to obtain solution 2;

[0047] 3) Mix solution 1 and solution 2 evenly, add citric acid and blackcurrant essence, and then set the volume to 1000ml, and stir evenly;

[0048] 4) Filtrate, after passing the quality inspection, fill in drop bottles, screw on the bottle caps with quantitative valves, and fill each bottle with 100ml of liquid medicine.

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Abstract

The invention provides levocetirizine hydrochloride oral drops good in taste and a preparation method thereof and belongs to the field of drug preparation. The levocetirizine hydrochloride oral drops are prepared from levocetirizine hydrochloride material, a solvent, a corrective, a preservative, a stabilizer, and a colorant, and the liquid medicine is quantitatively pumped out through a mechanical snap valve by using a quantitative dropper pump; the levocetirizine hydrochloride material has a concentration of 0.1-5 mg / ml in the drops herein. The liquid quantity of quantitative drops per snap is 0.1-2 ml. The levocetirizine hydrochloride oral drops are taken by an adult two to three times a day, 1-2 ml for each time. The levocetirizine hydrochloride oral quantitative drops are of a solvent type preparation and have the advantages medicine is distributed in a molecular form in liquid, may be quickly absorbed after administration, and acts fast; that dosage of the quantitative drops given by using the quantitative dropper pump is accurate, scientific and reasonable; the quantitative drops are sprayed directly into the mouth through a spray tube such that administration is greatly facilitated; the levocetirizine hydrochloride oral drops are good in taste and easy for a patient to accept.

Description

technical field [0001] The invention relates to an oral quantitative drop of levocetirizine hydrochloride for alleviating allergic symptoms and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] With the change of climate and environment, various harmful gases, dust and other pollution sources emerge in large numbers, which become allergens that cause people to have various allergic reactions. Seasonal changes, field work, pollen allergies, inhalation of harmful gases and dust particles, etc., have caused more and more people to suffer from various types of allergic diseases, allergic rhinitis, urticaria, skin redness, itching, redness Asthma caused by spots and allergens is very common. Therefore, it is very important to develop drugs for the treatment of allergic diseases. [0003] At present, the second-generation antihistamine drugs are mainly used in the clinical treatment of allergic diseases, ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/495A61P37/08A61J7/00
CPCA61J7/0053A61K9/0053A61K9/08A61K31/495A61K47/26
Inventor 李之韬马莉
Owner BEIJING VENTUREPHARM BIOTECH
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