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Preparation method of segmented copolymer material with temperature and pH (Potential of Hydrogen) sensitivity

A multi-block copolymer and sensitive technology, which is applied in the field of preparation of multi-block copolymer material P-b-PPEGMA, can solve the problems of low polymerization rate, less monomer range, use of metal, etc., and achieve high production yield, The effect of no pollution to the environment and bright application prospects

Active Publication Date: 2017-03-08
南京东焱氢能源科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the polymerization rate of the NMP method is low, and the range of applicable monomers is small; the ATRP method is not suitable for the direct polymerization of acidic, basic, amide or halogen-containing vinyl monomers, and its biggest defect is the use of metals in the polymerization process. , although with the continuous improvement of technology, the amount of metal has been greatly reduced, but due to related environmental and toxicological problems, the ATRP method has been limited as a commercial polymerization technology, especially in the medical field.

Method used

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  • Preparation method of segmented copolymer material with temperature and pH (Potential of Hydrogen) sensitivity
  • Preparation method of segmented copolymer material with temperature and pH (Potential of Hydrogen) sensitivity
  • Preparation method of segmented copolymer material with temperature and pH (Potential of Hydrogen) sensitivity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The first step of synthesis: Weigh 0.895g of methyl methacrylate monomer (MMA) and 2.81g of dimethylaminoethyl methacrylate (DMAEMA) into a 50 mL single-necked round bottom flask. Weigh 50 mg of the chain transfer agent 4-cyano-4-(thiobenzoyl)valeric acid and 8 mg of the initiator azobisisobutyronitrile (AIBN), put them in a 50 mL beaker, and add 15 mL of dioxane The solvent dissolves. The solution was poured into the flask, and the one-necked flask was evacuated at 0°C through the "T-shaped" tee, and nitrogen gas was introduced. Under the protection of nitrogen, place it at 70° C. for 12 h, and stir evenly with magnetic force. After the reaction was finished, the cooled product was dropped into 300 mL of ice petroleum ether, left to stand for 4 h, and the supernatant was removed to obtain a viscous sample at the bottom. The above steps were repeated once, and finally the samples were vacuum-dried at 40 °C for 48 h. Obtain pale pink P(MMA- co -DMAEMA) sample, yield ...

Embodiment 2

[0039] Same as Example 1, but the amount of methyl methacrylate monomer in the first step of synthesis becomes 0.385 g, methyl methacrylate monomer and chain transfer agent (4-cyano-4-(thiobenzyl Acyl) valeric acid) and the molar ratio of the initiator azobisisobutyronitrile was changed to 20:1:0.3.

Embodiment 3

[0041] Same as Example 1, but the amount of methyl methacrylate monomer in the first step of synthesis becomes 1.434 g, and in the system, methyl methacrylate monomer and chain transfer agent (4-cyano-4-(thiobenzyl Acyl) valeric acid) and the molar ratio of the initiator azobisisobutyronitrile was changed to 80:1:0.3.

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Abstract

The invention relates to a preparation method of a segmented copolymer material P(MMA-co-DMAEMA)-b-PPEGMA with temperature and pH (Potential of Hydrogen) sensitivity. According to the method, a copolymer poly(methyl methacrylate-co-dimethylaminoethyl methacrylate) is synthesized by adopting a reversible addition-fragmentation chain transfer polymerization method firstly; the synthesized poly(methyl methacrylate-co-dimethylaminoethyl methacrylate) as a macromolecular chain transfer agent is subjected to RAFT (Reversible Additive Fragment Transfer) polymerization with polyethylene glycol methyl ether methacrylate, so as to obtain the segmented copolymer material P(MMA-co-DMAEMA)-b-PPEGMA with the temperature and pH sensitivity. The method provided by the invention has the characteristics of simplicity and convenience, high preparation yield, no pollution to environment and the like; the prepared polymer material has high functionality and narrow molecular weight distribution, can be applied to organic dye adsorption and heavy metal adsorption, and medicine fields including in-vivo transportation of difficultly-soluble anti-cancer medicines and the like.

Description

technical field [0001] The invention belongs to the technical field of chemical engineering and new materials, and in particular relates to a preparation method of a temperature- and pH-sensitive multi-block copolymer material P(MMA-co-DMAEMA)-b-PPEGMA. Background technique [0002] The self-assembly behavior of environment-responsive multi-block copolymers in selective solvents is responsive and sensitive to the external environment, and is a hot spot in the field of polymer science research today. The self-assembly of polymers refers to the process in which molecules spontaneously construct aggregates with special structures and shapes under the impetus of weak interaction forces such as hydrogen bonds, electrostatic interactions, and van der Waals forces. Amphiphilic multi-block polymers have segments that have affinity for both the water phase and the oil phase. If a solvent can selectively dissolve one block in the block copolymer, it is another Block precipitants are ...

Claims

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Application Information

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IPC IPC(8): C08F293/00
CPCC08F293/005
Inventor 杨正龙刘芯岩
Owner 南京东焱氢能源科技有限公司
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