Preparation method of anti-coagulation hemodialysis membrane

Abstract

The invention relates to a preparation method of an anti-coagulation hemodialysis membrane. The preparation method includes the steps of: a) adding acrylonitrile and ethyl methacrylate into a reaction kettle according to mass ratio of 0.1-5.5:1, stirring the mixture and dropwise adding a polymerization initiator to initiate free radical polymerization to obtain an acrylonitrile-ethyl methacrylate copolymer; b) blending 1-5.5% of the acrylonitrile-ethyl methacrylate copolymer, 12-18% of polysulfone, 1-12% of an additive, and 65-85% of a solvent to prepare a membrane solution, and spinning the membrane solution to manufacture hollow-fiber hemodialysis membrane; and c) dissolving an active monomer containing an alkene double bond and a hydrophilic group in deionized water, and adding a cerium ammonium nitrate grafting initiator to prepare a soaking water solution, and soaking the hollow-fiber hemodialysis membrane in the soaking water solution to initiate a grafting reaction of the active monomer on the surface of the hollow-fiber hemodialysis membrane, and cleaning the hollow-fiber hemodialysis membrane. The surface hydrophilicity of the hemodialysis membrane is significantly improved. The hemodialysis membrane has high biocompatibility and anti-coagulation performance.

Description

Technical field [0001] The invention relates to a method for preparing an anticoagulant hemodialysis membrane, and belongs to the technical field of hollow fiber hemodialysis membranes. Background technique [0002] Hemodialysis is an effective alternative therapy for the treatment of acute and chronic renal failure. The clinical application of hemodialysis equipment consists of a dialysis machine, a water treatment system, a dialysate system and a dialyzer. It can replace the human kidney to achieve the purpose of blood purification. The process of hemodialysis is to selectively permeate the membrane as the separation medium and use the concentration gradient, osmotic pressure gradient and pressure gradient between the blood on both sides of the membrane and the dialysate to make the blood urea, myosinic acid and uric acid in patients with acute and chronic renal failure. Wait for toxins and excessive water retained in the body to diffuse to the dialysate. At the same time, re...

AI Technical Summary

Problems solved by technology

At present, commonly used synthetic dialysis membranes such as polysulfone (PSF), polymethylmethacrylate (PMMA), polyethersulfone (PES), polyamide (PA) and polyacrylonitrile (PAN) have large pore High permeability and ultrafiltration rate, high removal rate of medium and large molecular toxins, good mechanical properties, flexibility and certain biocompatibility, many applications, but their anticoagulant performance is not ideal , can cause some complications during hemodialysis

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