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Ginkgo biloba composition and its application in the preparation of Shuxuening injection

A technology of ginkgo biloba and its composition, which is applied in the application field of preparing Shuxuening injection, can solve the problems of difficult to effectively remove impurities of ginkgo leaf extract, low extraction rate, etc., achieve less impurities, good solubility, and reduce the The effect of allergic reactions

Active Publication Date: 2019-04-16
HEILONGJIANG ZBD PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The production process is relatively simple, but it is difficult to effectively remove impurities in ginkgo biloba extract by only cooling, and the extraction rate is low

Method used

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  • Ginkgo biloba composition and its application in the preparation of Shuxuening injection
  • Ginkgo biloba composition and its application in the preparation of Shuxuening injection
  • Ginkgo biloba composition and its application in the preparation of Shuxuening injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: Ginkgo biloba composition

[0039] 1. Extraction method

[0040](1) Get Ginkgo biloba ultrafine pulverization, add 9 times of acetic acid solution with pH of 2.5, ultrasonic treatment for 2h at 78°C, filter to obtain filter residue and extract for the first time; use 5 times of 55% ethanol with the filter residue , reflux extraction for 2 hours, filter and collect the filter residue and the second extraction solution, and use 4 times of 55% ethanol, glycerol and dichloromethane to reflux the filter residue for 1 hour, collect the extract solution, and combine the extract solution;

[0041] (2) adjust the pH with NaOH solution to be 7.6, leave it to stand for 20 hours, filter, add water to make it 5 times the volume of the ginkgo leaf amount;

[0042] (3) add concentrated hydrochloric acid to adjust pH to be 4.8, centrifuge at 4750r / min;

[0043] (4) The centrifuged liquid passes through the macroporous adsorption resin column at 1.7BV / h; the resin is was...

Embodiment 2

[0082] Embodiment 2: Ginkgo biloba composition

[0083] 1. Extraction method

[0084] (1) Get Ginkgo biloba ultrafine grinding, add 8 times of acetic acid solution with pH of 2.4, ultrasonic treatment for 1.5h at 75°C, filter to obtain filter residue and extract for the first time; use 4 times of 50% of the filter residue Ethanol, reflux extraction for 1 hour, filter and collect the filter residue and the second extract, then reflux extract the filter residue with a mixed solvent composed of 3 times 50% ethanol, glycerol and methylene chloride for 0.5 hour, collect the extract, and combine the extract;

[0085] (2) Regulate the pH with NaOH solution to be 7.5, let it stand for 12 hours, filter, add water to make it 5 times the volume of the ginkgo leaf amount;

[0086] (3) add concentrated hydrochloric acid to adjust pH to be 4.5, centrifuge at 4500r / min;

[0087] (4) The centrifuged liquid passes through the macroporous adsorption resin column with 1.6BV / h; with the purifie...

Embodiment 3

[0095] Embodiment 3: Ginkgo biloba composition

[0096] 1. Extraction method

[0097] (1) Get Ginkgo biloba ultrafine pulverization, add 10 times of hydrochloric acid solution with pH of 2.6, ultrasonic treatment for 3h at 80°C, filter to obtain filter residue and extract for the first time; use 6 times of 60% ethanol with the filter residue , reflux extraction for 2 hours, filter and collect the filter residue and the second extract, and then reflux extract the filter residue with a mixed solvent composed of 5 times 60% ethanol, glycerol and methylene chloride for 1.5 hours, collect the extract, and combine the extract;

[0098] (2) Regulate the pH with NaOH solution to be 8.0, let it stand for 24 hours, filter, add water to make it 6 times the volume of ginkgo leaves;

[0099] (3) add concentrated hydrochloric acid to adjust the pH to be 5.0, and centrifuge at 5000r / min;

[0100] (4) The centrifuged liquid passes through the macroporous adsorption resin column with 1.8BV / h...

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Abstract

The invention relates to a ginkgo leaf composition, in particular to a ginkgo leaf composition and application thereof for preparing a ginkgo biloba leaf extract injection. The ginkgo leaf composition is prepared from 25-43% of total flavonol glycosides, 6.5-17% of ginkgolides, 3-5% of bilobalide and smaller than 3 ppm of ginkgoic acid. According to the preparation method of the ginkgo leaf composition, two kinds of resin of DM130 and AB-8 are adopted for adsorption, the harmful ingredient total ginkgolic acid is effectively removed, and anaphylactoid reaction occurrences are reduced; meanwhile, various extracting methods and composite extracting agent repeated extraction are adopted, the target component content is high, the purity is good, and the product quality is improved. The obtained ginkgo biloba leaf extract injection is clear in compositional ratio, good in stability, good in solubility and stable in curative effect and contains few impurities.

Description

technical field [0001] The invention relates to a ginkgo leaf composition, in particular to a ginkgo leaf composition and its application in preparing Shuxuening injection. Background technique [0002] Ginkgo biloba is also known as Gongsun tree, ginkgo tree, etc. Its seeds, ginkgo, have a long history in my country as a traditional Chinese medicine for relieving cough, relieving asthma, reducing stool, and stopping turbidity. Its leaves, Ginkgo biloba, also known as ginkgo leaves, are the dried leaves of Ginkgo biloba, a plant of the family Ginkgoceae. The chemical composition of Ginkgo biloba is very complex. More than 170 compounds have been found so far, mainly flavonoids, terpenes, alcohols, alkaloids, polyisoprenes, polysaccharides and other active ingredients with pharmacological effects. The toxic ingredients are Ginkgolic acid. [0003] Ginkgo biloba is a traditional Chinese medicinal material for promoting blood circulation and removing blood stasis. The medici...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K36/16A61P9/10A61P3/06A61P35/00A61K127/00
CPCA61K9/0019A61K9/08A61K36/16A61K2236/15A61K2236/333A61K2236/35A61K2236/39A61K2236/53A61K2236/55
Inventor 方同华范玉奇周广红贾文娟崔玉海
Owner HEILONGJIANG ZBD PHARMA
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