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Pharmaceutical composition for improving safety of compound Herba Artemisiae Scopariae injection

A technology of composition and injection, which is applied in the field of medicine, can solve the problems of solution pH drop, polysorbate 80 is prone to rancidity, and accelerates the pH value of liquid medicine, etc., and achieves high dosage, improved safety, and good safety effects

Inactive Publication Date: 2017-02-15
CHENGDU XIANXIANXIAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the traditional Chinese medicine injection itself still has the problem that the pH value of the solution drops significantly during the sterilization and storage process, and polysorbate 80 (Tween 80) is prone to rancidity, which accelerates the drop of the pH value of the liquid medicine.

Method used

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  • Pharmaceutical composition for improving safety of compound Herba Artemisiae Scopariae injection
  • Pharmaceutical composition for improving safety of compound Herba Artemisiae Scopariae injection
  • Pharmaceutical composition for improving safety of compound Herba Artemisiae Scopariae injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]

[0027] Preparation method: Add water to decoct capillary and spring bupleurum twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the containing The amount of ethanol is 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate under reduced pressure When the relative density is about 1.15 (80°C), the medicinal solution will be used for later use; Panax notoginseng is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), and put Cool, add ethanol to make the ethanol content 65%, let it stand overnight, filter, concentrate the filtrate under reduc...

Embodiment 2

[0029]

[0030] Preparation method: Add water to decoct capillary and spring bupleurum twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the containing The amount of ethanol is 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate under reduced pressure When the relative density is about 1.15 (80°C), the medicinal solution will be used for later use; Panax notoginseng is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), and put Cool, add ethanol to make the ethanol content 65%, let it stand overnight, filter, concentrate the filtrate under reduc...

Embodiment 3

[0032]

[0033]Preparation method: Add water to decoct capillary and spring bupleurum twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the containing The amount of ethanol is 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate under reduced pressure When the relative density is about 1.15 (80°C), the medicinal solution will be used for later use; Panax notoginseng is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), and put Cool, add ethanol to make the ethanol content 65%, let it stand overnight, filter, concentrate the filtrate under reduce...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for improving safety of a compound Herba Artemisiae Scopariae injection. The pharmaceutical composition is used for injection and is mainly prepared from Herba Artemisiae Scopariae extract, Bupleuri Herba extract, Radix Notoginseng extract and polyoxyl 15 hydroxystearate. A cosolvent which is better in safety and more obvious in dissolving assisting effect replaces polysorbate 80 which is used as a cosolvent, has potential safety hazards and affects quality of products in the compound Herba Artemisiae Scopariae injection, the safety of the polyoxyl 15 hydroxystearate is higher than that of the polysorbate 80, the use amount is lower, probability and risks of adverse reactions of drugs are reduced, and safety of clinical medication is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for improving the safety of compound Yinchen injection. Background technique [0002] The standards of Compound Yinchen Injection are recorded in the Drug Standards issued by the Ministry of Health (Chinese Medicine Prescriptions). It has the effects of promoting blood circulation and promoting menstrual flow, dispelling blood stasis and relieving pain. It is clinically used to treat dysmenorrhea, amenorrhea, injury from tumbling, rheumatic arthralgia, etc. [0003] Compound Yinchen Injection has been widely used clinically in my country for many years, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reactions in the clinical application of traditional Chinese medicine injections have become more and more serious, which has affected the development of traditiona...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/19A61K47/14A61K36/282A61P15/00A61P29/00A61P19/04
CPCA61K9/08A61K9/0019A61K9/19A61K36/233A61K36/258A61K36/282A61K47/14A61K2300/00
Inventor 付裕
Owner CHENGDU XIANXIANXIAN BIOTECH CO LTD
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