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Pharmaceutical composition for improving safety of compound puerarin injection

A technology for puerarin and composition, which is applied in the field of pharmaceutical compositions for improving the safety of compound puerarin injection, can solve the problems of polysorbate 80 being prone to rancidity, accelerating the pH value of the medicinal solution, and decreasing the pH value of the solution, and improving the Safe, safe, high-dose effect

Inactive Publication Date: 2017-02-15
CHENGDU XIANXIANXIAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the traditional Chinese medicine injection itself still has the problem that the pH value of the solution drops significantly during the sterilization and storage process, and polysorbate 80 (Tween 80) is prone to rancidity, which accelerates the drop of the pH value of the liquid medicine.

Method used

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  • Pharmaceutical composition for improving safety of compound puerarin injection
  • Pharmaceutical composition for improving safety of compound puerarin injection
  • Pharmaceutical composition for improving safety of compound puerarin injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]

[0027] Preparation method: puerarin and Bupleurum are decocted twice with water for 2 hours each time. The decoction is combined and filtered. The filtrate is concentrated under reduced pressure to a relative density of 1.27~1.30 (80℃). Let it cool and add ethanol to make it contain ethanol. The amount is 65%, let stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrated to a relative density of 1.30 (80℃), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate to The relative density is about 1.15 (80℃), and the medicinal solution is ready for use; the velvet antler is decocted twice with water for 1 hour each time. The decoction is combined and filtered. The filtrate is concentrated to a relative density of 1.25-1.30 (80℃), and left to cool. Add ethanol to make the ethanol content 65%, let stand overnight, filter, and concentrate the filtrate under reduced pressure to a relative densit...

Embodiment 2

[0029]

[0030] Preparation method: puerarin and Bupleurum are decocted twice with water for 2 hours each time. The decoction is combined and filtered. The filtrate is concentrated under reduced pressure to a relative density of 1.27~1.30 (80℃). Let it cool and add ethanol to make it contain ethanol. The amount is 65%, let stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrated to a relative density of 1.30 (80℃), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate to The relative density is about 1.15 (80℃), and the medicinal solution is ready for use; the velvet antler is decocted twice with water for 1 hour each time. The decoction is combined and filtered. The filtrate is concentrated to a relative density of 1.25-1.30 (80℃), and left to cool. Add ethanol to make the ethanol content 65%, let stand overnight, filter, and concentrate the filtrate under reduced pressure to a relative densit...

Embodiment 3

[0032]

[0033] Preparation method: puerarin and Bupleurum are decocted twice with water for 2 hours each time. The decoction is combined and filtered. The filtrate is concentrated under reduced pressure to a relative density of 1.27~1.30 (80℃). Let it cool and add ethanol to make it contain ethanol. The amount is 65%, let stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrated to a relative density of 1.30 (80℃), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate to The relative density is about 1.15 (80℃), and the medicinal solution is ready for use; the velvet antler is decocted twice with water for 1 hour each time. The decoction is combined and filtered. The filtrate is concentrated to a relative density of 1.25-1.30 (80℃), and left to cool. Add ethanol to make the ethanol content 65%, let stand overnight, filter, and concentrate the filtrate under reduced pressure to a relative densit...

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PUM

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Abstract

The invention discloses pharmaceutical composition for improving safety of compound puerarin injection. The pharmaceutical composition is mainly prepared from puerarin extract, Chinese thorowax root extract, corn cervi pantotrichum extract and dibutyl fumarate and is used for injection. A cosolvent with better safety and more significant solubilization effect is used for substituting for a cosolvent polysorbate 80 having potential safety hazards, affecting product quality and existing in the compound puerarin injection, dibutyl fumarate is higher than polysorbate 80 in safety and lower in consumption, the probability and the risk of adverse reactions of the composition are reduced, and the clinical medication safety is improved.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition for improving the safety of compound puerarin injection. Background technique [0002] The standard for compound puerarin injection is included in the Pharmaceutical Standards (Prepared Chinese Medicine Prescriptions) issued by the Ministry of Health. The raw materials are puerarin, Bupleurum, and deer antler, which belong to traditional Chinese medicine injections. It has the effects of promoting blood circulation, clearing blood stasis and relieving pain. It is clinically used for the treatment of dysmenorrhea, amenorrhea, fall and flutter injury, rheumatic arthralgia, etc. [0003] The compound puerarin injection has been widely used clinically in my country for many years, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reactions in the clinical application of tradi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/14A61K36/233A61P15/00A61P29/00A61P19/04A61K35/32A61K31/352
CPCA61K9/08A61K9/0019A61K31/352A61K35/32A61K36/233A61K47/14A61K2300/00
Inventor 付裕
Owner CHENGDU XIANXIANXIAN BIOTECH CO LTD
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