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Antibacterial antipruritic ointment containing chlorophyll and preparation method thereof

A technology of chlorophyll and nisin, which can be used in medical preparations containing active ingredients, medical preparations with non-active ingredients, anti-inflammatory agents, etc., can solve problems such as affecting the quality of life of patients, inability to apply for a long time, and recurrence of itching, and achieve improvement. Dry skin condition, wrinkle reduction, effect enhancement effect

Active Publication Date: 2019-09-20
GUANGDONG COOWAY BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Skin pruritus seriously affects the quality of life of patients and requires timely and effective treatment. Currently, antihistamine H 1 and H 2 Receptor antagonists, glucocorticoids, antibiotics and immunomodulators are the main treatments, but they often cannot be used for a long time due to adverse reactions. Skin pruritus treatment has become an urgent problem to be solved
In addition, the excessive use of antibiotics will inhibit the beneficial bacteria in the body and make the flora unbalanced

Method used

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  • Antibacterial antipruritic ointment containing chlorophyll and preparation method thereof
  • Antibacterial antipruritic ointment containing chlorophyll and preparation method thereof
  • Antibacterial antipruritic ointment containing chlorophyll and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 antibacterial antipruritic ointment preparation

[0030] The antibacterial and antipruritic ointment described in the embodiment of the present invention 1 is made up of following raw materials prepared in percentage by weight: chlorophyll 10%, rice bran oil 8%, thymol 8%, alum 6%, auxiliary agent 5%, stabilizer 3% and Matrix 60%;

[0031] Wherein, the auxiliary agent is composed of hexapeptide and oligoarginine with a weight ratio of 1:0.2;

[0032] The stabilizer is composed of tert-butyl p-hydroxyanisole and 2-phenylbenzimidazole-5-sodium sulfonate in a weight ratio of 1:0.6;

[0033] The matrix is ​​composed of the following preparation raw materials in percentage by weight: 10% lanolin, 15% white petrolatum, 6% cetyl alcohol, 5% isopropyl myristate, 15% glycerin, 8% polyglycerol fatty acid ester, Nisin 0.5%, the balance is water.

[0034] Preparation:

[0035] (1) get chlorophyll, add its weight 50% dehydrated alcohol to dissolve, then add thymol, ...

Embodiment 2

[0039] Embodiment 2 antibacterial antipruritic ointment preparation

[0040] The antibacterial and antipruritic ointment described in the embodiment of the present invention 2 is made up of following raw materials prepared in percentage by weight: 15% of chlorophyll, 10% of bran oil, 10% of thymol, 4% of alum, 6% of auxiliary agent, 5% of stabilizer and Matrix 50%;

[0041] Wherein, the auxiliary agent is composed of hexapeptide and oligoarginine with a weight ratio of 0.5:0.05;

[0042] The stabilizer is composed of tert-butyl p-hydroxyanisole and 2-phenylbenzimidazole-5-sodium sulfonate in a weight ratio of 1.5:0.8;

[0043]The matrix is ​​composed of the following raw materials in weight percent: 5% lanolin, 20% white petrolatum, 10% cetyl alcohol, 8% isopropyl myristate, 10% glycerin, 6% polyglycerol fatty acid ester, Nisin 0.2%, the balance is water.

[0044] The preparation method is the same as in Example 1.

Embodiment 3

[0045] Example 3 Preparation of antibacterial and antipruritic ointment

[0046] The antibacterial and antipruritic ointment described in the embodiment of the present invention 3 is made up of following raw materials prepared in percentage by weight: chlorophyll 10%, rice bran oil 5%, thymol 5%, alum 8%, auxiliary agent 5%, stabilizer 2% and Matrix 65%;

[0047] Wherein, the auxiliary agent is composed of hexapeptide and oligoarginine with a weight ratio of 0.8:0.1;

[0048] The stabilizer is composed of tert-butyl p-hydroxyanisole and sodium 2-phenylbenzimidazole-5-sulfonate in a weight ratio of 1:0.2.

[0049] The matrix is ​​composed of the following raw materials in percentage by weight: 10% lanolin, 10% white petrolatum, 8% cetyl alcohol, 2% isopropyl myristate, 20% glycerin, 8% polyglycerol fatty acid ester, Nisin 0.4%, the balance is water.

[0050] The preparation method is the same as in Example 1.

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Abstract

The invention relates to an antibacterial antipruritic ointment containing chlorophyll and a preparation method thereof. The antibacterial antipruritic ointment containing chlorophyll is prepared from chlorophyll, millet bran oil, thymol crystals, alum, assistant, stabilizer and base material, wherein the assistant is a mixture of hexa-polypeptide and arginine oligomer; the stabilizer is a mixture of tertiary butyl hydroxyanisole and 2-phenylbenzimidazole-5-sodium sulfonate; the base material is prepared from wool grease, albolene, cetyl alcohol, isopropyl myristate, glycerinum, polyglycerol fatty acid ester, ethyl p-hydroxybenzoate and the balance water. The antibacterial antipruritic ointment containing chlorophyll is safe and effective, has the functions of being antibacterial, sterilizing, relieving itching, promoting tissue regeneration and restoring, effectively relieves the symptoms along with skin itch, such as decrustation and corrugation, and is small in irritation and causes no anaphylaxis.

Description

technical field [0001] The invention relates to an external preparation, in particular to an antibacterial antipruritic ointment containing chlorophyll and a preparation method thereof. Background technique [0002] Pruritus is not only the main symptom of many skin diseases, but also an independent disease. It is the most common clinical manifestation of skin diseases such as dermatitis, eczema, urticaria, contact dermatitis, prurigo nodularis, xeroderma, superficial fungal infections, psoriasis, and atopic dermatitis. Studies have found that there are selective receptors closely related to itching in the human body, such as histamine receptors, neuropeptide receptors, neurokine receptors, cannabinoid receptors, and protease-activated receptor-2 (PAR-2). Bacteria and fungi in the environment, dust mite antigens with serine protease activity, and serine proteases secreted by immune cells can all be recognized by PAR-2, and the abnormal skin keratinocytes are activated throu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K36/899A61K47/22A61K47/10A61P29/00A61P17/04A61P17/00A61P31/00A61K33/06A61K31/785A61K31/555A61K31/05
Inventor 陈松彬易萍倪彦艳刘杰森张爱萍李小翠
Owner GUANGDONG COOWAY BIOTECH CO LTD
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