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Natural drug composition for treatment of osteoporotic fracture and/or osteoarthritis and application thereof

A technology of natural medicine and osteoarthritis, which is applied in the field of natural medicine composition for the treatment of osteoporotic fractures and/or osteoarthritis, can solve the problems of side effects and curative effect, and achieve the solution of side effects and poor curative effect, and eliminate knee joint slippage Effects of inflammatory cells in membranous synovial fluid

Active Publication Date: 2017-01-18
ZHEJIANG INNOVATION WISDOM VALLEY TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the defects in the above-mentioned prior art, the object of the present invention is to provide a natural medicinal composition for treating osteoporotic fractures and / or osteoarthritis and its application, the natural medicinal composition is compatible, safe in dose, The effect is obvious, and it can effectively solve the problems of side effects and poor efficacy of existing Chinese and Western medicines in the treatment of osteoporotic fractures and / or osteoarthritis

Method used

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  • Natural drug composition for treatment of osteoporotic fracture and/or osteoarthritis and application thereof
  • Natural drug composition for treatment of osteoporotic fracture and/or osteoarthritis and application thereof
  • Natural drug composition for treatment of osteoporotic fracture and/or osteoarthritis and application thereof

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preparation example Construction

[0029] The preparation method of raw material preparation of the present invention can adopt following three kinds:

[0030] 1) The preparation of seabuckthorn fruit oil, common methods are as follows:

[0031] ①Physical pressing and centrifugal separation: Seabuckthorn fruit juice and seabuckthorn fruit puree are obtained by pressing (removing seeds) from ripe fresh seabuckthorn fruits (seeded) through an air screw rod. The fruit puree is soaked in warm water at 50-55°C for 2-3 times, lightly soaked for 60 minutes, centrifuged and purified several times, and the oil extraction rate of seabuckthorn fruit oil is 0.07%-4.0% (g / g).

[0032] ②CO 2 Supercritical extraction: sea buckthorn ripe fresh fruit (seed removed), obtained sea buckthorn fruit puree. Extraction conditions for industrial production: extraction pressure 35MPa, extraction temperature 45°C. The extraction time is 1.5h, and the separation temperature is 45°C. The oil extraction rate can reach 5.2% (g / g). Add w...

Embodiment 1

[0042] The natural medicine composition for treating osteoporotic fractures and / or osteoarthritis is composed of a medicament prepared from raw materials in the following mass percentages: 94.6% seabuckthorn fruit oil, 5.4% total notoginseng saponins.

Embodiment 2

[0044] The natural medicinal composition for treating osteoporotic fractures and / or osteoarthritis, the composition is composed of a medicament prepared from the following raw materials by mass percentage: 87.2.% of seabuckthorn fruit oil, 12.8% of Panax notoginseng saponins .

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Abstract

Belonging to the technical field of research on the dose-effect of natural drug prescription compatibility and use, the invention discloses a natural drug composition for treatment of osteoporotic fracture and / or osteoarthritis and application thereof. The natural drug composition comprises, by mass percentage, 73.3%-98.3% of sea buckthorn fruit oil and 1.7%-26.7% of panax notoginseng saponins. The natural drug composition can transform and generate a signal molecule of eicosatrienoic acid, and the signal molecule can activate protein and cyclic nucleotide, calcium ion and other multi-path molecular signal pathways to generate the effect of synergistic amplification of signal molecule; the composition can improve the hematopoietic microenvironment, regulate endocrine, adjust the metabolic balance of osteoclast and osteoblast, reduce alkaline phosphatase, improve serum osteoprotegerin, osteocalcin and other bone metabolism marker indexes, increase the femur, tibia and vertebral bone density, significantly improves the bone remodeled bone shape and bone biomechanical symbolic indexes, and can effectively prevent and treat osteoporotic fracture, osteoarthritis and ostealgia diseases.

Description

technical field [0001] The invention belongs to the technical field of research on the dosage, effect and function of the compatibility of natural medicine prescriptions, and in particular relates to a natural medicine composition for treating osteoporotic fractures and / or osteoarthritis and its application. Background technique [0002] Osteoporosis is a systemic metabolic bone disease characterized by low bone mass and destruction of bone microarchitecture, resulting in increased bone fragility and susceptibility to fracture. Osteoporotic fractures are the most serious consequence of osteoporosis. Fractures caused by osteoporosis are fragility fractures. Due to the decrease in bone strength, non-violent actions in daily life can cause fractures. Such fractures are complete fractures and have a high prevalence in the elderly. Common fracture sites are the thoracolumbar spine, proximal humerus, and distal radius, and the elderly are prone to multiple fractures in the hip an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A23L33/00A61P19/08A61P19/02
CPCA61K36/185A61P19/02A61P19/08A61K36/258A61K2300/00
Inventor 魏霞蓁宋兰兰韩少华
Owner ZHEJIANG INNOVATION WISDOM VALLEY TECH CO LTD
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