Preparation method of functional fine micro pills

Abstract

The invention relates to a preparation method of functional fine micro pills. The method comprises the following steps of (1) preparing silicon dioxide micro balls with the particle diameter being smaller than 0.15mm; (2) spraying and covering medicine active ingredients onto the surfaces of the silicon dioxide micro balls in a solution or suspension mode to obtain medicine carried fine micro pills; (3) sequentially covering an insulation layer and a function layer on the surfaces of the medicine carried fine micro pills to obtain the functional fine micro pills. The method has the advantages that the control is easy; the large-scale production can be performed; the particle diameter of the obtained fine micro pills is small enough; the palatability is good; the method is widely applicable to the preparation of medicine preparation such as ordinary tablets and slow release preparations, particularly oral suspension liquid and oral dry suspensions.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation method of functional fine pellets. Background technique [0002] At present, some oral solid forms such as tablets have proven difficult and even dangerous for children and the elderly, in which case we usually need more suitable dosage forms, such as chewable or disintegrating in the mouth tablets, and granules that can be dispersed and suspended in water. When it comes to such uses, it is usually necessary to prepare particles with a particle size small enough to avoid the drug formulation causing the user a gritty feeling or difficulty swallowing during oral administration. The preparation of particles with a sufficiently small particle size is also conducive to the development of more pharmaceutical preparations. For example, fine pellets with a taste-masking effect can be used for ordinary oral tablets, orally disintegrating tablets, and ...

AI Technical Summary

Problems solved by technology

[0003] The existing technology usually adopts the method of preparing microspheres or microcapsules to realize the preparation of fine pellets. However, due to the difficulty in large-scale production of microsphere (capsule) technology, and the involvement of many organic solvents, the process is not easy to control, and the production It is not easy to realize the preparation of fine pellets due to the low yield rate and other reasons.