Temperature Fusion and Control System of Isolated Organ Perfusion Apparatus

Abstract

The invention relates to a temperature fusion and control system of an isolated organ perfusion instrument. The system comprises a main control unit, a four-channel temperature acquisition unit, a compressor unit, a ventilation valve unit and a constant temperature control unit, wherein the four-channel temperature acquisition unit, the compressor unit and the ventilation valve unit are electrically connected with the main control unit; and the constant temperature control unit comprises a temperature fusion subunit based on improved Bayesian estimation and a temperature control subunit based on a fuzzy PID (Proportion Integration Differentiation) controller. By adopting the data fusion subunit based on improved Bayesian estimation, possible sensor failure or false data caused by environmental interference is overcome; four paths of measured data are fused into one path of data, and the fuzzy PID control subunit is adopted to implement high-precision constant temperature control. The system not only can effectively improve the temperature control precision of the isolated organ perfusion instrument, but also can reduce the risk of measurement failure caused by external interference and improve the stability of the instrument, and thus has potential economical value.

Description

technical field [0001] The invention belongs to the field of medical equipment, in particular to a temperature fusion and control system of an isolated organ perfusion instrument. Background technique [0002] Maintaining a low temperature environment is the basis for protecting isolated organ cells and tissues. The protective mechanism is as follows: organ resection and local ischemia lead to lack of ATP (adenosine triphosphate) energy and oxygen supply, so that organ cells rapidly transform from aerobic metabolism to anoxic metabolism, producing Lactic acid and protons, and cell depolarization occurs, resulting in ion concentration imbalance and cell necrosis. Relevant scholars have found that the increase of proton and calcium concentration is the direct cause of cell death. However, the basic principle of biochemical reactions is molecular movement and migration, and it is governed by the heat gained, in other words, the decrease in temperature will cause the molecular ...

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Problems solved by technology

[0003] Studies have shown that the best storage temperature for isolated organs is 4°C. At this time, it can not only avoid direct freezing damage, but also greatly reduce the energy metabolism level of tissue cells and improve the tissue's ability to resist ischemia. However, high-precision liquid temperature control is better than high-precision temperature control. Motion control is much more difficult, especially for flowing perfusion solutions in large spaces. The reason is not only the problem of high-precision sensors, but more importantly, the liquid temperature control itself has the characteristics of large inertia, large time lag and nonlinearity.

[0004] In view of this characteristic, the use of intelligent control algorithms such as fuzzy control, neural network, predictive control, PID and genetic algorithm can achieve the purpose of rapid response of the system, but a single algorithm cannot meet the requirements of high precision and fast response at the same time, and the relationship between intelligent algorithms combined and complex

In addition, in the traditional isolated organ perfusion instrument temperature fusion and control method, due to factors such as temperature sensor failure or environmental interference, it may provide false temperature measurement data, which will mislead the automatic setting of the instrument. It will also bring misjudgment to organ caregivers, and ultimately bring immeasurable life and economic losses

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