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Chinese and Western compound medicine for treating progressive spinal muscular atrophy and preparing method thereof

A spinal muscular atrophy and drug technology, applied in the field of medicine, can solve the problems of not being able to improve motor function and muscle strength, delay the time of respiratory dysfunction, reduce excitotoxicity, etc., and achieve good muscular dystrophy without adverse and toxic side effects , significant effect

Inactive Publication Date: 2016-12-07
王延林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs such as riluzole currently used reduce the release of glutamate in the central nervous system, reduce excitotoxicity, delay the occurrence of respiratory dysfunction and prolong the survival period of patients, but cannot improve motor function and muscle strength; although traditional Chinese medicine does not Dependence, drug resistance and toxic side effects, but the effect is slightly slower

Method used

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  • Chinese and Western compound medicine for treating progressive spinal muscular atrophy and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The raw material composition and weight of the active ingredients of the medicine of the present invention are: 87 parts of tiger fur grass, 84 parts of sweet pomegranate, 82 parts of coix seed, 80 parts of pine leaves, 77 parts of epimedium, 72 parts of milk chai, 69 parts of half maple root, 67 parts of stone brush, 65 parts of fern, 62 parts of elk horn, 60 parts of Melaleuca, 58 parts of Achyranthes bidentata, 57 parts of asparagus, 53 parts of Wukou tree, 14 parts of elemental meal, 1.9 parts of amberium chloride, 1.7 parts of piribedil and 1.4 parts of neostigmine.

[0042] The processing steps of the pharmaceutical preparation method of the present invention are:

[0043] (1) Wash the fresh tiger fur grass and black tree, put it in a juicer to squeeze out the juice, refrigerate for 4 hours, filter, remove impurities and sediment, decolorize through activated carbon adsorption, and concentrate to a water content of 30 %-40% extract, for subsequent use;

[0044] ...

Embodiment 2

[0051] The raw material composition and weight of the active ingredients of the medicine of the present invention are: 75 parts of tiger skin grass, 72 parts of sweet pomegranate, 70 parts of coix seed, 68 parts of pine leaves, 66 parts of epimedium, 59 parts of milk chai, 57 parts of half maple root, 55 parts of stone brush, 52 parts of fern, 50 parts of elk horn, 49 parts of Melaleuca, 46 parts of Achyranthes bidentata, 44 parts of asparagus, 39 parts of Wukou tree, 13 parts of elemental meal, 1.5 parts of ambemonium chloride, 1.3 parts of piribedil and 1.1 parts of neostigmine.

[0052] The process steps, usage and dosage of the medicine preparation method in this embodiment are the same as those in Example 1.

Embodiment 3

[0054] The raw material composition and weight of the active ingredients of the medicine of the present invention are: 71 parts of tiger fur grass, 67 parts of sweet pomegranate, 64 parts of coix seed, 62 parts of pine leaves, 59 parts of epimedium, 54 parts of milk chai, 50 parts of half maple root, 49 parts of stone brush, 47 parts of fern, 44 parts of elk horn, 40 parts of Melaleuca, 38 parts of Achyranthes bidentata, 40 parts of asparagus, 35 parts of Wukou tree, 10 parts of elemental meal, 1.1 parts of amberium chloride, 0.8 parts of piribedil and 0.6 parts of neostigmine.

[0055] The process steps, usage and dosage of the medicine preparation method in this embodiment are the same as those in Example 1.

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Abstract

The invention discloses Chinese and Western compound medicine for treating progressive spinal muscular atrophy and a preparing method thereof, and belongs to the technical field of medicine. The medicine is prepared from large-leaved chrysosplenium, sweet pomegranate, semen coicis, pine needles, herba epimedii, ficus lyrata, heterophyllous wing seedtreeroot, nude fern herb, silverweed cinquefoil root, David's deerhorn, cajeput, radix achyranthis bidentatae, radix asparagi, tarenna attenuata, elemental diet, ambenonium chloride, piribedil and neostigmine. The adopted Chinese and Western medicine combined treatment method has a better effect than that of just using traditional Chinese medicine or Western medicine, with the treatment rule of nourishing liver and kidney, strengthening the muscles and bones, dispelling wind and removing obstruction in the meridians, nourishing heart, tonifying qi and moistening and promoting granulation, the traditional Chinese medicine components and Western medicine effects are improved with the maximum efficiency, complementation and promotion functions are brought into play, the medicinal effect is improved, central nervous systems of nerves, internal secretion and immunity of the organism are stimulated to carry out stress response, and the Chinese and Western compound medicine has good treat effects on muscular atrophy, skin numb, myasthenia, periodic paralysis and myodystrophy caused by progressive spinal muscular atrophy.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to a Chinese and Western compound medicine for treating progressive spinal muscular atrophy and a preparation method thereof. Background technique [0002] Progressive spinal muscular atrophy, also known as spinal muscular atrophy or spinal muscular atrophy, is a type of disease that causes muscle weakness and atrophy due to degeneration of the anterior horn motor neurons of the spinal cord and the motor nucleus of the brainstem. Clinically, it is progressive and symmetrical, with extensive flaccid paralysis and muscle atrophy mainly in the proximal limbs. [0003] Clinical manifestations of progressive spinal muscular atrophy: [0004] (1) The age of onset is about 30 years old, slightly earlier than ALS, and it is more common in men. [0005] (2) Assault onset, showing symptoms and signs of lower motor neuron dysfunction such as muscle weakness, muscle atrophy, and fasciculatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61P25/28A61P21/00A61K35/32A61K31/165A61K31/506A61K31/27
CPCA61K31/165A61K31/27A61K31/506A61K35/32A61K36/11A61K36/15A61K36/185A61K36/21A61K36/296A61K36/60A61K36/61A61K36/73A61K36/74A61K36/8965A61K36/8994A61K2236/31A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 王延林李若龙周艳
Owner 王延林
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