Compound atenolol nanoemulsion antihypertensive medicine

Abstract

The invention discloses a compound atenolol nano-emulsion antihypertensive drug. The raw materials and the mass percentages thereof are: atenolol 1%-15%, surfactant 5%-35%, cosurfactant 1% %~20%, oil 1%~20%, Eucommia ulmoides water extract 0.5%~10%, Moutan bark water extract 0.5%~10%, the rest components are distilled water, and the sum of the mass percentages of the above raw materials is 100%. The nano-emulsion droplet has small particles, uniform distribution, low viscosity and good fluidity. After atenolol is prepared into a nanoemulsion, the ability to pass through the blood-brain barrier is significantly increased, the bioavailability of the original drug is significantly improved, the half-life of the drug is prolonged, and the number of administrations is reduced; nanoemulsion improves atenolol Atenolol's drug dissolving and penetrating ability increases the stability of atenolol; and after compounding with the water extracts of Eucommia ulmoides and Paeonia suffruticosa, it has obvious synergistic effect, and the drug efficacy is more fully exerted.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of an antihypertensive drug atenolol, in particular to a compound atenolol nanoemulsion antihypertensive drug. technical background [0002] Atenolol (Atenolol), molecular formula: C 14 h 22 N 2 o 3 , molecular weight: 266.34. This product is a cardioselective β-receptor blocker with no membrane stabilizing effect and no endogenous sympathomimetic activity. Generally used for sinus tachycardia and premature beats, etc., can also be used for hypertension, angina pectoris and glaucoma. [0003] Atenolol has the effect of competitively inhibiting catecholamines at the adrenoceptor β receptor site, but mainly inhibits the activity of β1 receptors. By weakening or preventing the excitation of β receptors, the contraction force and contraction velocity of the heart are reduced, and the conduction velocity through the conduction system is slowed down, so that the heart's res...

AI Technical Summary

Problems solved by technology

[0005] Existing antihypertensive drugs such as atenolol tablets are available on the market now. Although they can be absorbed from the gastrointestinal tract after oral administration, the absorption rate is slow and incomplete. In addition, the dissolution rate of the drug in the tablet is slow and the bioavailability is poor. Coupled with the slow action of atenolol itself, the drug effect of atenolol cannot be utilized quickly

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