Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Tetracaine hydrochloride pharmaceutical composition and preparation method thereof

A technology of tetracaine hydrochloride and its composition, which is applied in the field of tetracaine hydrochloride pharmaceutical composition and its preparation, can solve the problems of low purity and poor taste of fat-soluble lubricants, and achieve good anesthesia performance and antioxidant capacity Good, performance-enhancing effects

Inactive Publication Date: 2016-12-07
西安利君精华药业有限责任公司
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the lubricant in the existing tetracaine hydrochloride is a fat-soluble lubricant, and the mouthfeel of the fat-soluble lubricant is not good, and there is also the shortcoming that the purity is not high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The invention provides a tetracaine hydrochloride pharmaceutical composition, which consists of the following raw materials:

[0028] Crude 2-(dimethylamino)ethyl 4-(butylamino)benzoate hydrochloride (the crude product was purified), polyethylene glycol, peppermint oil and grapeseed oil.

[0029] Wherein, the weight ratio of purified 4-(butylamino)benzoic acid-2-(dimethylamino)ethyl hydrochloride crude product, polyethylene glycol, peppermint oil and grape seed oil is 10:1:0.5:0.2.

Embodiment 2

[0031] The invention provides a tetracaine hydrochloride pharmaceutical composition, which consists of the following raw materials:

[0032] Crude 2-(dimethylamino)ethyl 4-(butylamino)benzoate hydrochloride (the crude product was purified), polyethylene glycol, peppermint oil and grapeseed oil.

[0033] Wherein, the weight ratio of purified 4-(butylamino)benzoic acid-2-(dimethylamino)ethyl hydrochloride crude product, polyethylene glycol, peppermint oil and grape seed oil is 50:2:0.8:0.5.

Embodiment 3

[0035] The invention provides a tetracaine hydrochloride pharmaceutical composition, which consists of the following raw materials:

[0036] Crude 2-(dimethylamino)ethyl 4-(butylamino)benzoate hydrochloride (the crude product was purified), polyethylene glycol, peppermint oil and grapeseed oil.

[0037] Wherein, the weight ratio of purified 4-(butylamino)benzoic acid-2-(dimethylamino)ethyl hydrochloride crude product, polyethylene glycol, peppermint oil and grape seed oil is 15:1:0.7:0.3.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a tetracaine hydrochloride pharmaceutical composition. The tetracaine hydrochloride pharmaceutical composition is prepared by the steps: purifying a crude product of 4-(butylamino) benzoic acid-2-(dimethylamino) ethyl ester hydrochloride, mixing the purified 4-(butylamino) benzoic acid-2-(dimethylamino) ethyl ester hydrochloride with polyethylene glycol, peppermint oil and grape seed oil sequentially, thereby obtaining the product. The invention also discloses a method for preparing the tetracaine hydrochloride pharmaceutical composition. The method comprises the following steps: purifying the crude product of 4-(butylamino) benzoic acid-2-(dimethylamino) ethyl ester hydrochloride, thereby obtaining a purified product; and mixing polyethylene glycol and the purified product for stirring, adding the peppermint oil and grape seed oil, stirring, performing vacuum concentration and cooling, thereby obtaining the tetracaine hydrochloride pharmaceutical composition. The tetracaine hydrochloride pharmaceutical composition prepared by the invention has the advantages of high purity, good lubricating property, small dosage and excellent anesthetic effect.

Description

technical field [0001] The invention relates to the technical field of medicines, more specifically, the invention relates to a tetracaine hydrochloride pharmaceutical composition with high purity, good lubricity, no irritation to the body and good taste and a preparation method thereof. Background technique [0002] With the improvement of people's living standards and changes in diet structure, more and more people are troubled by gastritis, colitis and other gastrointestinal diseases. Gastroscopy has become the most commonly used and reliable method for diagnosing gastrointestinal diseases at present. It can directly observe the condition of the patient's stomach. Any other examination method, including upper gastrointestinal barium contrast, electrogastrogram and B-ultrasound and so on cannot replace it. [0003] Tetracaine hydrochloride is a local anesthetic, which has the advantages of pain relief and definite anesthesia effect, and is widely used in the field of micr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/245A61K36/534A61K47/44A61K47/10A61P23/02
CPCA61K31/245A61K36/534A61K47/10A61K47/44A61K2300/00
Inventor 王锋怀
Owner 西安利君精华药业有限责任公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com