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Metformin hydrochloride sustained-release tablet and preparation method thereof

A technology of metformin hydrochloride and sustained-release tablets, which can be applied to pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. and other problems, to achieve the effect of stable blood concentration and high bioavailability

Active Publication Date: 2016-12-07
NANHAI PHARMA CHONGQING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, because metformin hydrochloride itself has a certain degree of gastric irritation, some patients have adverse reactions of gastric discomfort.
The above technology improves the bioavailability of metformin sustained-release tablets by increasing the residence time of the drug in the stomach, which will increase the time of adverse reactions in the stomach to some extent, so it still has certain drawbacks

Method used

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  • Metformin hydrochloride sustained-release tablet and preparation method thereof
  • Metformin hydrochloride sustained-release tablet and preparation method thereof
  • Metformin hydrochloride sustained-release tablet and preparation method thereof

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preparation example Construction

[0035] This embodiment also provides a method for preparing the above-mentioned metformin hydrochloride sustained-release tablet, which includes:

[0036] a. The absorption enhancer, metformin hydrochloride and binder are mixed and granulated.

[0037] Specifically, prepare solution A with an absorption enhancer, the concentration of the absorption enhancer in solution A is 8-12%, preferably 10%; then mix metformin hydrochloride and binder, then mix with solution A and wet granulate , dried and granulated.

[0038] The above-mentioned absorption promoter includes chitosan and calcium dihydrogen phosphate; the above-mentioned binder includes povidone and sodium carboxymethyl cellulose.

[0039] Preferably, chitosan and calcium dihydrogen phosphate are prepared into Solution A with water.

[0040] Preferably, metformin hydrochloride, povidone and sodium carboxymethylcellulose are passed through a 60-100 mesh sieve, preferably an 80 mesh sieve, before mixing evenly, and then mi...

Embodiment 1

[0047] The present embodiment provides a kind of metformin hydrochloride slow-release tablet, and the raw material of this slow-release tablet is as shown in Table 1, and the preparation method of this slow-release tablet is:

[0048] a. Prepare solution A with chitosan and calcium dihydrogen phosphate, then mix metformin hydrochloride, povidone and sodium carboxymethylcellulose, then mix with solution A and wet granulate, dry and granulate.

[0049] b. Mix the prepared granules with hypromellose, microcrystalline cellulose and magnesium stearate, and compress into tablets.

Embodiment 2

[0051] The present embodiment provides a kind of metformin hydrochloride slow-release tablet, and the raw material of this slow-release tablet is as shown in Table 1, and the preparation method of this slow-release tablet is:

[0052] a. Chitosan and calcium dihydrogen phosphate are mixed with water to be 8% solution A; Metformin hydrochloride, povidone and sodium carboxymethyl cellulose are respectively passed through a 100 mesh sieve, mixed evenly and added to solution A, Wet granulation, drying at 60°C and sizing to 15 mesh to obtain granules.

[0053] b. Mix the prepared granules with hypromellose, microcrystalline cellulose and magnesium stearate, and compress into tablets.

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Abstract

The invention provides a metformin hydrochloride sustained-release tablet and a preparation method thereof, and belongs to the field of pharmacy. The metformin hydrochloride sustained-release tablet comprises metformin hydrochloride, a binding agent, an absorption accelerant, hydroxypropyl methylcellulose and a pharmaceutical adjuvant. The weight ratio of the metformin hydrochloride, the binding agent and the absorption accelerant is 500:(45-55):(2.5-3.5). The preparation method of the sustained-release tablet includes the steps: mixing and palletizing the absorption accelerant, the metformin hydrochloride and the binding agent; mixing palletized materials, the hydroxypropyl methylcellulose and the pharmaceutical adjuvant; pressing the mixture to obtain the metformin hydrochloride sustained-release tablet. The sustained-release tablet can widen absorbing windows of the metformin hydrochloride is high in bioavailability, blood concentration of the metformin hydrochloride can be maintained at treatment level in long time, and diseases are effectively treated. According to the method, the hydroxypropyl methylcellulose is added after palletizing, the sustained-release performance of the sustained-release tablet is greatly improved, and better treatment effects are achieved.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a metformin hydrochloride sustained-release tablet and a preparation method thereof. Background technique [0002] Metformin hydrochloride (metformin hydrochloride), chemical name: 1,1-dimethylbiguanide hydrochloride, molecular formula: C 4 h 11 N 5 ·HCl, molecular weight: 165.63, chemical structure formula is as follows: [0003] [0004] Metformin hydrochloride is a biguanide oral hypoglycemic drug used for the treatment of non-insulin-dependent diabetes mellitus. It is an antidiabetic drug that can control blood sugar levels and improve macrovascular complications. Metformin hydrochloride has a good hypoglycemic effect, and can reduce the risk of blood lipids and cardiovascular diseases at the same time. It has the advantages of long-term drug safety and high cost performance, and is widely recommended as the first-line drug for type Ⅱ diabetes. [0005] Metformin hydrochloride ...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K47/38A61K31/155A61P3/10
CPCA61K9/0002A61K9/2059A61K31/155
Inventor 邹世红聂凯向开洋毛光荣范时根杜宗涛徐进
Owner NANHAI PHARMA CHONGQING
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