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Preparation method of silver-based absorption iodine [<125>I] seal seed source

A sealed seed source, silver-based technology, applied in preparations for in vivo experiments, pharmaceutical formulas, radioactive preparations in vivo, etc., can solve the problems of long reaction time, toxic chlorine gas, unfavorable production, etc., and achieve high yield and oxidation The effect of mild conditions and short reaction time

Inactive Publication Date: 2016-11-23
JIANGSU HUAYI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage of this type of method is that a large amount of toxic and irritating gas chlorine will be produced during the preparation process, which will cause great risks to operators and the environment
Chinese patent 1106860 uses hydrogen peroxide as an oxidant, the oxidation process is mild and environmentally friendly, but the hydrochloric acid used in chlorination is corrosive and is a precursor drug
But the shortcoming of this method is that reaction time is longer, is unfavorable for production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Pretreatment of silver wire:

[0024] Take 100 silver wires and put them into the reaction bottle, add 1ml H in order 2 o 2 (30%) and 2ml NaCl (2mol / L) carry out oxidation, chlorination, and this moment, the rotating speed of shaker is 10r / min, and the reaction time is about 1h, after reaction finishes, wash three times with purified water, dry;

[0025] 2. Iodine [ 125 I] Adsorption

[0026] Take the pretreated silver wire, add 0.25ml NaI (1mg / ml), 0.50ml NaBr (1mg / ml), 0.75ml acetic acid-sodium acetate buffer solution (pH3.6) and 0.1-1000mCi of radioactive Na 125 1, the shaking table rotating speed is 10r / min, and the reaction times is about 1h, can obtain silver-based adsorption iodine [ 125 I] Sealed seed source.

Embodiment 2

[0028] 1. Pretreatment of silver wire:

[0029] Take 50 silver wires and put them into the reaction bottle, add 100ml H in order 2 o 2 (5%) solution and 10ml NaCl (0.2mol / L) solution are carried out oxidation, chlorination, and this moment, the rotating speed of shaker is 10r / min, and the reaction time is about 10h, washes three times with purified water after reaction finishes, dries;

[0030] 2. Iodine [ 125 I] Adsorption

[0031] Take the pretreated silver wire, add 1ml NaI (2mg / ml) solution, 2ml NaBr (5mg / ml) solution, 5ml acetic acid-sodium acetate buffer solution (pH3.6) and 0.1-1000mCi radioactive Na 125 1, the shaking table rotating speed is 10r / min, and the reaction times is about 10h, can obtain silver-based adsorption iodine [ 125 I] Sealed seed source.

Embodiment 3

[0033] 1. Pretreatment of silver wire:

[0034] Take 10 silver wires and put them into the reaction bottle, add 2ml H in order 2 o 2 (50%) solution and 20ml NaCl (0.5mol / L) solution are carried out oxidation, chlorination, and this moment, the rotating speed of shaker is 10r / min, and the reaction time is about 0.5h, after reaction finishes, wash three times with purified water, dry;

[0035] 2. Iodine [ 125 I] Adsorption

[0036] Take the pretreated silver wire, add 10ml NaI (10mg / ml) solution, 1ml NaBr (10mg / ml) solution, 2ml acetic acid-sodium acetate buffer solution (pH3.6) and 0.1-1000mCi radioactive Na 125 1, the shaking table rotating speed is 10r / min, and the reaction times is about 0.2h, can obtain silver-based adsorption iodine [ 125 I] Sealed seed source.

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Abstract

The invention relates to a preparation method of a silver-based absorption iodine [<125>I] seal seed source. The method comprises the steps of taking filamentary silver and putting into a reaction flask, adding 5-50% of hydrogen peroxide, adding a chloride solution, evenly mixing and reacting for 0.5-15h; cleaning the obtained filamentary silver with purified water or an organic solvent, and then drying; adding a buffer solution with a pH value of 1-6 into the dried filamentary silver, adding 0.1-1000mCi radioactive sodium iodide [<125>I] solution and adding NaBr at the same time, and reacting for 0.2-20h; after the reaction, drying the filamentary silver in the air, putting the dried filamentary silver into a titanium tube and sealing. The preparation method of the silver-based absorption iodine [<125>I] seal seed source is mild in reaction, less in photodegradation activity loss and free from pollution to environment; the technology is mild in oxidizing condition, short in reaction time and high in yield.

Description

technical field [0001] The invention relates to the field of radioactive medical treatment, in particular to a novel silver-based adsorbed iodine[ 125 I] Preparation method of sealed seed source. Background technique [0002] iodine[ 125 I] Radioactive sealed seed source interventional therapy is a method of radiation therapy for tumors. Under the guidance of CT and ultrasound, iodine[ 125 I] The radioactive sealed seed source is implanted into the tumor tissue. By emitting low-energy γ-rays, the tumor tissue is continuously and most destructively killed. Compared with conventional external beam therapy, iodine[ 125 I] Radioactive sealed seed sources have significant advantages: small dose of internal radiation, longer duration of action, more accurate treatment positioning, uniform local effect on tumors, small radiation radius (about two centimeters), and minimal damage to surrounding normal tissues. A very good local treatment for cancer. It has been widely used in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/02A61K51/12A61P35/00A61K101/02
CPCA61K51/02A61K51/1282
Inventor 金志明张思伟王芳
Owner JIANGSU HUAYI TECH
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