Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition with palmitoyl ascorbate and antitumor medicine in synergism

An anti-tumor drug, palmitoyl ester technology, used in anti-tumor drugs, drug combinations, active ingredients of heterocyclic compounds, etc., can solve problems such as poor targeting and large systemic side effects

Inactive Publication Date: 2016-11-23
陈西敬
View PDF4 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0034] The purpose of the present invention is to provide a novel drug with definite curative effect and little side effect for the current clinical treatment of cancer, especially the shortcomings of large systemic side effects and poor targeting in existing drugs for the treatment of malignant tumors, which can be injected or taken orally. Dosage Form Administration

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition with palmitoyl ascorbate and antitumor medicine in synergism
  • Pharmaceutical composition with palmitoyl ascorbate and antitumor medicine in synergism
  • Pharmaceutical composition with palmitoyl ascorbate and antitumor medicine in synergism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0486] Embodiment 1: vitamin C palmitoyl ester liposome for injection

[0487]

[0488] Weigh the prescribed amount of vitamin C palmitoyl ester, soybean lecithin and cholesterol, dissolve them in dichloromethane, and place them in a rotary evaporator to dry under reduced pressure to form a uniform lipid film, then place them in a vacuum drying oven to dry overnight , add water for injection to hydrate, ultrasonically remove the film, undergo ultrasonic treatment with a probe or high-pressure homogeneous treatment, and finally filter through a 0.22 μm microporous membrane to obtain the whole grain.

Embodiment 2

[0489] Embodiment 2: compound liposome for injection

[0490]

[0491] Weigh the prescribed amount of vitamin C palmitoyl ester, docetaxel, phospholipids and cholesterol, dissolve in dichloromethane, and place in a rotary evaporator to dry under reduced pressure to form a uniform lipid film, and place in a vacuum drying oven After drying overnight, add water for injection to hydrate, ultrasonically remove the film, undergo ultrasonic treatment with a probe or high-pressure homogeneous treatment, and finally filter through a 0.22 μm microporous membrane to obtain the final product.

Embodiment 3

[0492] Embodiment 3: Vitamin C Palmitoyl Ester Nanoparticles for Injection

[0493]

[0494] Dissolve PLGA in acetone to form PLGA acetone solution, add vitamin C palmitoyl ester to PLGA acetone solution as oil phase, dissolve soybean lecithin in ethanol solution, add poloxamer, DSPE-PEG-BIOTIN, remove organic The solvent is used as the water phase, and the oil phase is added dropwise to the water phase stirred at constant temperature. After the dropwise addition is completed, the stirring is continued to remove the organic solvent, and it is put into a dialysis bag for overnight dialysis, and then mannitol is added to freeze-dry to obtain the product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a medicine for treating malignant tumors, in particular to an L-palmitoyl ascorbate antitumor medicine applied in the way of intravenous injection or oral administration or intratumor injection or the like. The pharmaceutically acceptable medicine applied in an injection or oral administration dosage form is prepared from L-palmitoyl ascorbate or / and one or more kinds of other chemotherapeutic medicine in combination. The medicine has high physicochemical stability and a definite antitumor effect; in-vitro cell tests and tumor-bearing mouse tests show that the medicine or a composition thereof has an effect on various malignant tumors such as breast cancer, liver cancer, lung cancer, stomach cancer, pancreatic cancer, cervical cancer, gliomas, prostatic cancer and colorectal cancer.

Description

technical field [0001] The invention relates to a medicine for treating malignant tumors, especially vitamin C palmitoyl ester anti-cancer drugs for intravenous injection, oral administration or intratumoral injection. and two other chemotherapeutic drugs, prepared into a pharmaceutically acceptable injection or oral dosage form for administration. The medicine of the present invention has excellent physical and chemical stability and definite anti-tumor effect. In vitro cell tests and tumor-bearing mouse tests show that the medicine or its composition is effective against breast cancer, liver cancer, lung cancer, gastric cancer, pancreatic cancer, cervical cancer, Cancer, glioma, prostate cancer, colorectal cancer and other malignant tumors are effective. Background technique [0002] Vitamin C (Vitamin C) is also called ascorbic acid (Ascorbic acid), the chemical formula is C 6 h 8 o 6 . It was first isolated and reported by Hungarian scientist and Nobel Prize winner ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K45/06A61K31/375A61K31/704A61K31/337A61K31/475A61K31/4745A61K31/282A61K33/24A61K31/7068A61K31/44A61P35/00
CPCA61K31/282A61K31/337A61K31/375A61K31/44A61K31/4745A61K31/475A61K31/704A61K31/7068A61K33/24A61K45/06A61K2300/00
Inventor 卢杨王子厚杨越陈西敬赵娣李宁陈琪马恩龙张玲
Owner 陈西敬
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com