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Pharmaceutical composition of amrinone and application of pharmaceutical composition in hypertension treatment

A technology of amrinone and composition, which is applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems that have not been reported related to renovascular hypertension, etc., and achieve outstanding substantive features, Significant progress, the effect of improving the treatment effect

Inactive Publication Date: 2016-11-16
赵吉永
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there has been no report on the correlation between the pharmaceutical composition of amrinone and renovascular hypertension

Method used

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  • Pharmaceutical composition of amrinone and application of pharmaceutical composition in hypertension treatment
  • Pharmaceutical composition of amrinone and application of pharmaceutical composition in hypertension treatment
  • Pharmaceutical composition of amrinone and application of pharmaceutical composition in hypertension treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0019] Separation method: (a) Grind the dried rhizome (2kg) and extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L×3 times) 3 times), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) The ethyl acetate extract in (a) was removed with D101 type macroporous resin, first eluted with 25% ethanol for 8 column volumes, then with 70% ethanol for 10 column volumes, collected 70% eluate, and reduced Concentrate under pressure to get 70% ethanol elution concentrate; (c) in step (b), 70% ethanol elution concentrate is separated with normal phase silica gel, and the volume ratio is 85:1 (10 column volumes), 45:1 successively (8 column volumes), 25:1 (10 column vo...

Embodiment 2

[0022] Embodiment 2: pharmacological action

[0023] 1. Materials and methods

[0024] 1.1 Animals

[0025] SD rats, weighing 200-250 g, were purchased from the Department of Animals, Xiangya School of Medicine, Central South University. They were fed for 1wk in our laboratory before the experiment, and their basal blood pressure was measured.

[0026] 1.2 Reagents and samples

[0027] Amrinone was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Angiotensin Ⅱ and renin activity detection kits were purchased from the Institute of Radioimmunology, General Hospital of the People's Liberation Army; the rest were commercially available analytically pure.

[0028] 1.3 Instruments

[0029] High-speed centrifuge (produced in France); electrophoresis system (produced by Beijing Liuyi Instrument); mouse tail manometer (HX-1 type) was purchased from Xiangy...

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Abstract

The invention discloses a pharmaceutical composition of amrinone and application of the pharmaceutical composition in hypertension treatment. Amrinone and a novel-structure natural product compound (I) separated out of dried rhizomes of blackberry lily are contained in the pharmaceutical composition of amrinone, and when amrinone and the natural product compound (I) act independently, the treatment effect on renal vascular hypertension is achieved; when amrinone and the natural product compound (I) act jointly, the treatment effect on renal vascular hypertension is further improved, the pharmaceutical composition can be developed into medicine for treating renal vascular hypertension, and compared with the prior art, prominent substantive features and remarkable progress are achieved.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of amrinone, in particular to a pharmaceutical composition of amrinone and its application in the treatment of hypertension. Background technique [0002] Amrinone, also known as Amrinone, Amrinone, Amrinone, Amrinone, Ampirone, Anlianone, Anoke, Qiangxinlong, Amrinone Lactate, is a new type of non-glucoside, non- Catecholamine cardiotonic drugs, both oral and intravenous injection are effective, have both positive inotropic effect and vasodilation effect, can increase myocardial contractility, increase cardiac output, reduce cardiac preload and afterload, and reduce left ventricular filling pressure. Improves left ventricular function, increases cardiac index, but has no significant effect on mean arterial pressure and heart rate. [0003] Renovascular hypertension is secondary to many cardiovascular diseases, such as atherosclerosis, renal artery stenosis, etc., and i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/00A61K31/444A61K31/365A61P9/12A61P13/12
CPCA61K31/365A61K31/444A61K36/88C07D307/00A61K2300/00A61P9/12A61P13/12
Inventor 不公告发明人
Owner 赵吉永
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