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Cefaclor medicinal composition and acute lung injury protection effect thereof

A technology of cefaclor and its composition, which is applied in the field of cefaclor pharmaceutical composition, can solve the problems that have not yet been reported on cefaclor and the prevention and treatment of lung injury, and achieve outstanding substantive features, significant progress, and preventive and therapeutic effects Improved effect

Inactive Publication Date: 2016-11-09
赵吉永
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there are no related reports on the relationship between cefaclor and the prevention and treatment of lung injury

Method used

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  • Cefaclor medicinal composition and acute lung injury protection effect thereof
  • Cefaclor medicinal composition and acute lung injury protection effect thereof
  • Cefaclor medicinal composition and acute lung injury protection effect thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0019] Separation method: (a) Grind the dried rhizome (2kg) of Acorus calamus, extract with 90% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate until there is no alcohol smell (4L), and then use petroleum ether (4L ×3 times), ethyl acetate (4L×3 times) and water-saturated n-butanol (4L×3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) In the step (a), the n-butanol extract is removed with AB-8 macroporous resin, first eluted with 8% ethanol for 10 column volumes, then with 70% ethanol for 12 column volumes, and collected 70% eluate , concentrated under reduced pressure to obtain 70% ethanol eluted concentrate; (c) in step (b), 70% ethanol eluted concentrate was separated with normal phase silica gel, and the volume ratio was 40:1 (8 column volumes), 20 :1 (8 column volumes), 10:1 (8 column volumes)...

Embodiment 2

[0022] Embodiment 2: pharmacological action

[0023] 1. Materials and methods

[0024] 1.1 Animals

[0025] Healthy male clean-grade SD rats with a body weight of 320-370 g (provided by the Animal Experiment Center of Nanjing Military Region General Hospital) were selected. The animals were kept in a ventilated and dry environment with a temperature of (22±1)°C, a relative humidity of 55%-65%, and a 12-h light cycle, and were fed with maintenance diet 1022 for rats and mice.

[0026] 1.2 Reagents and samples

[0027] Cefaclor was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Rat tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), enzyme-linked immunosorbent assay (ELISA) detection kits were purchased from Biosource, USA International Company; rat HMGB1 ELISA detection kit was purchased from Japan Shino-Test Company. ...

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PUM

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Abstract

The invention discloses a cefaclor medicinal composition and an acute lung injury protection effect thereof. The cefaclor medicinal composition contains cefaclor and a natural product compound (I) having a novel structure and separated from dry rhizome of Grassleaf Sweelflag Rhizome, and cefaclor and the natural product have lung injury prevention and treatment effects in the individual action process; and cefaclor and the natural product have further improved lung injury prevention and treatment effects when being combined, so cefaclor and the natural product can be used to develop lung injury prevention and treatment medicines. Compared with medicines in the prior art, the medicinal composition has protruding characteristics and substantial progresses.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of cefaclor, in particular to a pharmaceutical composition of cefaclor and its protective effect on acute lung injury. Background technique [0002] Cefaclor is a second-generation oral cephalosporin, which has a strong killing effect on a variety of Gram-positive and Gram-negative bacteria. This product is a broad-spectrum semi-synthetic cephalosporin antibiotic. The activity against penicillinase-producing Staphylococcus aureus, group A hemolytic streptococcus, viridans streptococcus and staphylococcus epidermidis is the same as that of cefadroxil, and the antibacterial effect against non-enzyme-producing staphylococcus aureus and pneumococcus is higher than that of cefadroxil 2 to 4 times stronger. The activity against Gram-negative bacilli, including Escherichia coli and Klebsiella pneumoniae, is stronger than cephalexin, similar to cefadroxil, and the activity aga...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00A61K31/545A61K31/56A61P11/00
CPCA61K31/545A61K31/56A61K36/888C07J63/008A61K2300/00A61P11/00C07J63/00
Inventor 不公告发明人
Owner 赵吉永
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