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Blood-glucose-lowering traditional Chinese medicine composition as well as preparation method and application

A composition and hypoglycemic technology, applied in the direction of drug combination, application, pharmaceutical formulation, etc., can solve problems such as unclear mechanism of action, unclear active ingredients, dysfunction of pancreatic islets, etc., achieve significant blood lipid function, increase HDL-C , the effect of regulating blood lipid function

Active Publication Date: 2016-11-09
HUBEI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) Islet dysfunction
Invention patent CN103893729B A kind of hypoglycemic traditional Chinese medicine preparation, a total of 25 traditional Chinese medicines, the dosage is large, the active ingredient is not clear, and the mechanism of action is not clear
Moreover, a large number of non-"medicine and food homologous" medicinal materials are used as clinical drugs for the treatment of diabetes, but there are potential safety hazards as long-term use of preventive drugs or health food

Method used

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  • Blood-glucose-lowering traditional Chinese medicine composition as well as preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A (20 grams of mulberry leaves, 10 grams of bitter melon, 15 grams of kudzu root) was extracted with 8 times the amount of 55% ethanol at 55° C. for 1 hour, and then repeated for one hour. The extract was filtered while it was hot, and the filtrates were combined for later use.

[0044] The filter residue was mixed with 15 g of B yam, then extracted with 7 times the amount of 30% ethanol at 55°C for 2 hours, filtered while hot, combined with the above filtrate, and the ethanol was recovered by vacuum distillation to obtain a concentrated solution T1 for use.

[0045] Add 8 times the amount of purified water to the obtained mixed medicinal residues, extract in boiling water for 1 hour, filter while hot, and take the filtrate, add appropriate amount of pure water to the medicinal residues to repeatedly extract once, filter while hot, and combine the two filtrates to obtain the extract T2.

[0046] T1 and T2 were combined, concentrated to a specific gravity of 1.35, and the...

Embodiment 2

[0050] A (25 grams of mulberry leaves, 15 grams of balsam pear, 15 grams of kudzu root) and 10 grams of B yam were extracted with 6 times the amount of 50% ethanol at 50 for 1 hour, and then 5-10 times the amount of 30% ethanol at 50 ℃—60℃ for reflux extraction for 2 hours, the extract was filtered while it was hot, the filtrate was distilled under reduced pressure to recover ethanol until complete, and the extract T3 was obtained for later use.

[0051] Add 10 times the amount of purified water to the medicinal residues, extract in boiling water for 1 hour, filter while hot, and take the filtrate, add appropriate amount of pure water to the medicinal residues to repeatedly extract once, filter while hot, and combine the two filtrates to obtain the extract T4.

[0052] Combine T3 and T4, concentrate to a specific gravity of 1.15, and obtain extract J2 for preservation.

[0053] The extract J2 is prepared by adding (or not adding) an appropriate amount of purified water, adding...

Embodiment 3

[0056] a) Use 10 times the amount of 70% ethanol in A (30 grams of mulberry leaves, 10 grams of bitter gourd, and 20 grams of kudzu root), adjust the pH to 4.5 with hydrochloric acid, and extract at 60°C for 2 hours under reflux, repeat the extraction once, and extract while hot Filter, and adjust the pH value of the filtrate to 7 with NaHCO3, and set aside. Ethanol was recovered by distillation under reduced pressure until complete, and filtered to obtain an extract.

[0057] b) Herbal dregs are mixed with 5 grams of B yam, and then 5 times the amount of 30% ethanol is used for reflux extraction at 50° C. for 1.5 hours. The extract is filtered while it is hot, combined with the extract obtained in a), and the ethanol is recovered by distillation under reduced pressure until complete. Filter to obtain extract T5.

[0058] c) Add 10 times the amount of purified water to the above medicinal residues, boil and extract for 1 hour, filter while hot, take the filtrate, add appropri...

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Abstract

The invention discloses a blood-glucose-lowering traditional Chinese medicine composition as well as a preparation method and application. Active components of the blood-glucose-lowering traditional Chinese medicine composition are prepared from a group A and a group B through gradient extraction of 70 percent to 30 percent alcohol-water solution or / and water, wherein the group A is prepared from the following components in parts by weight: 20 to 30 parts of folium mori, 10 to 20 parts of bitter gourds and 10 to 20 parts of radix puerariae; the group B comprises 5 to 15 parts of rhizoma dioscoreae by weight. Pharmaceutically acceptable auxiliary materials are added into the active components to prepare oral preparations including oral solutions, granules, tablets, hard capsules, soft capsules, pills and the like according to a conventional method. A pharmacodynamics test result shows that the blood-glucose-lowering traditional Chinese medicine composition can be used for remarkably lowering blood glucose, glycated hemoglobin (GHb) of experiment rats with type 2 diabetes mellitus and improving oxidative stress indexes, and also has a remarkable blood lipid regulation function and can be used for raising HDL-C (High Density Lipoprotein-Cholesterol) and lowering TC (Total Cholesterol), TG (Triglyceride) and LDL-C (Low-Density Lipoprotein Cholesterol). The active components of the traditional Chinese medicine composition are matched with rice and flour and can be processed into health foods capable of preventing and treating diabetes mellitus, such as porridge, noodles, bread and biscuits.

Description

technical field [0001] The invention discloses a traditional Chinese medicine composition for lowering blood sugar, a preparation method and application thereof. It involves the fields of traditional Chinese medicine preparation technology and food processing technology. Background technique [0002] Diabetes (DM) is caused by a variety of pathogenic factors acting on the body, leading to hypofunction of islets, insulin can not play a corresponding regulatory role, and then lead to a series of metabolic disorder syndrome. The highest incidence rates are type 1 diabetes and type 2 diabetes. The clinical manifestations of different types of diabetes are different, and hyperglycemia is their common denominator. [0003] Type 1 diabetes is mainly manifested by the destruction of pancreatic beta cells and relatively insufficient insulin content, but the body is still sensitive to insulin and requires long-term use of insulin for treatment. The main manifestations of type 2 dia...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P3/10A23L33/105
CPCA23V2002/00A61K36/42A61K36/488A61K36/605A61K36/8945A61K2236/331A61K2236/333A61K2236/39A61K2300/00A23V2200/328
Inventor 陈运中
Owner HUBEI UNIV OF CHINESE MEDICINE
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