Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of qi tonifying and blood activating medicines to preparing medicines for chronic arrhythmia

A technology for invigorating qi, activating blood circulation, and arrhythmia, which is applied in drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve the problems of poor patient compliance, high price, and unpopularity, and achieve cure or clinical symptoms, improve clinical symptoms, and improve survival quality effect

Active Publication Date: 2016-11-09
SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern Western medicine uses aminophylline, isoproterenol, atropine, ephedrine and other drugs and installs a pacemaker, and the clinical effect is remarkable. However, because the above drugs have their own side effects and poor patient compliance, they should not be used for a long time
Pacing therapy is not yet popular due to high technical and equipment requirements and high price

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of qi tonifying and blood activating medicines to preparing medicines for chronic arrhythmia
  • Application of qi tonifying and blood activating medicines to preparing medicines for chronic arrhythmia
  • Application of qi tonifying and blood activating medicines to preparing medicines for chronic arrhythmia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The medicine tablet that is used for the treatment of bradyarrhythmia is made of the crude drug of following parts by weight:

[0040]

[0041]

[0042] The preparation method of the medicine tablet comprises the following steps: taking ginseng, coptis, vinegar corydalis, hawthorn and half the amount of astragalus in the raw materials, pulverizing them into fine powder, and decocting the remaining eight-flavored raw materials and the remaining astragalus with water twice , 2 hours for the first time, 1.5 hours for the second time, combine the decoction, filter, and when the filtrate is concentrated to 90°C, the relative density is 1.06-1.12, let it cool, add double the amount of ethanol to precipitate, take the supernatant, and recover Ethanol, and concentrated to a clear paste with a relative density of 1.20-1.22 at 90°C, mixed with the above-mentioned medicinal powder, made into granules, dried, compressed into 1000 tablets (small tablets), coated with sugar or f...

Embodiment 2

[0044] The medicinal capsule for the treatment of bradyarrhythmia is made of the bulk drug of following parts by weight:

[0045]

[0046] The preparation method of the drug capsule comprises the following steps: taking ginseng, coptis, vinegar corydalis, hawthorn and half of the astragalus in the raw materials, pulverizing them into fine powder, and decocting the remaining eight-flavored raw materials and the remaining astragalus twice with water , 2 hours for the first time, 1.5 hours for the second time, combine the decoction, filter, and when the filtrate is concentrated to 90°C, the relative density is 1.06-1.12, let it cool, add double the amount of ethanol to precipitate, take the supernatant, and recover Ethanol, and concentrated to a clear paste with a relative density of 1.20-1.22 at 90°C, mixed with the above-mentioned medicinal powder, and made into capsules. For the treatment of sinus bradycardia, and / or second-degree atrioventricular block, and / or third-de...

Embodiment 3

[0048] The medicinal granule for the treatment of bradyarrhythmia is made of the bulk drug of following parts by weight:

[0049]

[0050]

[0051]

[0052] The preparation method of the drug granules comprises the following steps: taking ginseng, coptis, vinegar corydalis, hawthorn and half of astragalus in the raw materials, pulverizing them into fine powder, decocting the remaining eight-flavored raw materials and the remaining astragalus with water twice , 2 hours for the first time, 1.5 hours for the second time, combine the decoction, filter, and when the filtrate is concentrated to 90°C, the relative density is 1.06-1.12, let it cool, add double the amount of ethanol to precipitate, take the supernatant, and recover Ethanol, and concentrated to a clear paste with a relative density of 1.20-1.22 at 90°C, mixed with the above-mentioned medicinal powder to make granules. For the treatment of sinus bradycardia, and / or second-degree atrioventricular block, and / o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of qi tonifying and blood activating medicines to preparing medicines for chronic arrhythmia. The qi tonifying and blood activating medicines comprises, by weight, 100-150 parts of radix astragali, 80-120 parts of radix codonopsis, 60-100 parts of radix salviae miltiorrhizae, 60-100 parts of radix puerariae, 60-100 parts of herba epimedii, 60-100 parts of fructus crataegi, 40-80 parts of radix rehmanniae, 40-80 parts of radix angelicae sinensis, 40-80 parts of rhizoma coptidis, 40-80 parts of vinegar-processed rhizoma corydalis, 40-80 parts of ganoderma, 20-30 parts of radix ginseng and 20-30 parts of radix glycyrrhizae preparata. The application has the advantages that as discovered by pharmacodynamic experimental research, definite vasodilatation effects can be realized by the qi tonifying and blood activating medicines, and obvious effects of scavenging nitrogen free radicals, hydroxyl free radicals and nitroxide free radicals can be realized by the qi tonifying and blood activating medicines; calm heart rates, total 24-hour heartbeat numbers, the maximum heart rates, the minimum heart rates and the average heart rates of chronic arrhythmia patients can be increased by the aid of the medicines, and as shown by randomized controlled trial, positive curative effects are realized by the medicines in an embodiment 1 of the invention for the chronic arrhythmia.

Description

technical field [0001] The invention belongs to the field of application of traditional Chinese medicines, and in particular relates to the application of a drug for invigorating qi and promoting blood circulation in the preparation of a drug for bradyarrhythmia. Background technique [0002] Arrhythmia (arrhythmia) is due to abnormal sinoatrial node excitation or excitation outside the sinoatrial node, the conduction of the excitation is slow, blocked, or conducted through abnormal channels, that is, the origin of cardiac activity and / or conduction disorders lead to the frequency of cardiac beating And (or) abnormal rhythm. The types of arrhythmia include sinus tachycardia, sinus bradycardia, sinus arrest, sinoatrial block, sick sinus syndrome, etc. Different types of arrhythmia have different treatment options such as medication . [0003] Bradyarrhythmia is one of the common syndromes in cardiovascular system diseases, mainly including sinus bradycardia, atrioventricula...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/804A61P9/06
CPCA61K9/2004A61K36/074A61K36/232A61K36/258A61K36/296A61K36/344A61K36/481A61K36/484A61K36/488A61K36/537A61K36/66A61K36/718A61K36/734A61K36/804A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 孟晓萍姜作玲张斯斯洪毅王辉
Owner SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com