Diflunisal pharmaceutical composition and medical application thereof

A technology of diflunisal and its composition, which is applied in the field of pharmaceutical composition and its application in AIDS, can solve the problems that have not been reported related to AIDS of diflunisal, and achieve outstanding substantive features and improved treatment effect , the effect of significant progress

Inactive Publication Date: 2016-10-26
胡逸穹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between diflunisal and its pharmaceutical composition and AIDS

Method used

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  • Diflunisal pharmaceutical composition and medical application thereof
  • Diflunisal pharmaceutical composition and medical application thereof
  • Diflunisal pharmaceutical composition and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0019] Separation method: (a) Grind the red ginseng (2kg), extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L×3 times) ), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a ) in the ethyl acetate extract with D101 type macroporous resin to remove impurities, first elute 8 column volumes with 25% ethanol, then elute 12 column volumes with 70% ethanol, collect 70% eluate, and concentrate under reduced pressure Obtain 70% ethanol elution concentrate; (c) in step (b), 70% ethanol elution concentrate is separated with normal phase silica gel, is 85:1 (10 column volumes), 45:1 (8 column volumes) successively with volume ratio column volume), 25:1 (10 column volu...

Embodiment 2

[0022] Embodiment 2: pharmacological action

[0023] In this example, rhesus monkeys were inoculated intravenously with SIVmac virus solution to prepare AIDS model monkey models, and the drugs were observed to improve CD 4+ Cell percentage and CD 4+ / CD 8+ Ratio, and promote T, B lymphocyte proliferation and other aspects of the anti-AIDS effect.

[0024] 1. Materials and methods

[0025] 1.1 Animals

[0026] Rhesus monkeys weighing 5-7kg, healthy males, no SIV positive by PCR test before infection, normal blood routine, provided by the Institute of Experimental Animals, Chinese Academy of Medical Sciences.

[0027] 1.2 Reagents and samples

[0028] Diflunisal was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Monoclonal antibodies were purchased from the Biological Agents Development Center of the Academy of Military Medical Sciences. AZT (azidethymi...

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Abstract

The invention discloses a diflunisal pharmaceutical composition and medical application thereof. The diflunisal pharmaceutical composition provided by the invention contains diflunisal and a natural product compound (I) novel in structure, when diflunisal and the compound (I) independently affect, CD4<+> cell number and immunologic function can be improved, immunologic balance can be adjusted, and therapeutical effect on Aids is realized; and when diflunisal and the compound (I) jointly act, the therapeutical effect is further improved, a medicine for treating the Aids can be developed, and prominent substantiality characteristic and obvious progress are realized compared with the prior art.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of diflunisal, in particular to a pharmaceutical composition of diflunisal and its application in AIDS. Background technique [0002] Diflunisal is a salicylic acid derivative, which has antipyretic, analgesic, and anti-inflammatory effects, which are stronger than aspirin in analgesic and anti-inflammatory effects and last longer, and have less gastrointestinal irritation. [0003] So far, there has been no report on the correlation between diflunisal and its pharmaceutical composition and AIDS. Contents of the invention [0004] The object of the present invention is to provide a pharmaceutical composition of diflunisal, which contains diflunisal and a natural product with novel structure, and diflunisal and the natural product can synergistically treat AIDS. [0005] Above-mentioned purpose of the present invention is achieved by following technical scheme: [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J73/00C07J53/00A61K31/603A61P31/18A61K31/585
CPCC07J73/003A61K31/585A61K31/603C07J53/004A61K2300/00
Inventor 胡逸穹
Owner 胡逸穹
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