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Four-in-one plush thread artificial liver bioreactor

A bioreactor and artificial liver technology, applied in the field of bioartificial liver, can solve the problems of cumbersome operation, complex structure, high cost, etc., and achieve the effect of convenient operation, simple system structure and uniform heating

Active Publication Date: 2018-03-13
WUHAN TOGO MEDITECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the disadvantages of the plasma separator, the oxygen coupler and the bioreactor in the existing bioartificial liver support system, which are of high cost, cumbersome operation and complex structure, and provide a method for realizing plasma separation, oxygen coupler and bioreactor. Coupling, bioreactor and incubator four-in-one and simultaneously realize pH regulation, uniform cell filling, sufficient material exchange, increase of liver cell growth density and activity, and simple operation of constant temperature heating of the reactor artificial liver bioreactor

Method used

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  • Four-in-one plush thread artificial liver bioreactor
  • Four-in-one plush thread artificial liver bioreactor
  • Four-in-one plush thread artificial liver bioreactor

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Embodiment Construction

[0036] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0037] like figure 1 , figure 2 , image 3 The four-in-one plush thread artificial liver bioreactor shown includes a constant temperature water tank 2 and a three-in-one bioreactor 1 placed inside it;

[0038] The three-in-one bioreactor 1 comprises a cavity 1.4 and a first partition 1.5 and a second partition 1.6 arranged in the cavity 1.4; the first partition 1.5 and the second partition 1.6 separate the cavity 1.4 from the left The three independent spaces to the right are plasma separator 1.1, oxygenator 1.2 and reactor 1.3;

[0039] The plasma separator 1.1 and the oxygenator 1.2 are connected from the outside through the chamber connecting pipe 6, and the separation pump 12 is provided on the chamber connecting pipe 6; the reactor 1.3 and the oxygenator 1.2 pass through the second partition 1.6 The communication hole 7 open...

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Abstract

The invention discloses a four-in-one plush thread type artificial liver bioreactor, which includes a constant temperature water tank and a three-in-one bioreactor placed inside it; the three-in-one bioreactor includes a cavity and is arranged in the cavity The first partition and the second partition in the body; the first partition and the second partition divide the cavity into three independent spaces from left to right, followed by plasma separator, oxygenator and reactor ; The constant temperature water tank includes a water tank shell and a hot water inlet and a hot water outlet located on the water tank shell. The beneficial effects of the present invention are: after the blood enters the plasma separator, the plasma enters the oxygenator and the reactor in turn, reducing unnecessary pipelines; it can provide a suitable metabolic environment for cells and ensure cell activity; it can increase the effective cell filling volume and ensure The cells are evenly distributed laterally.

Description

technical field [0001] The invention belongs to the technical field of bioartificial liver, in particular to a four-in-one plush thread type artificial liver bioreactor. Background technique [0002] The bioartificial liver support system mainly uses cell groups with liver metabolism function to purify the blood of patients with liver failure, realize the function of liver support in vitro, and win precious time for liver regeneration or waiting for liver transplantation, which has important clinical application value. In the bioartificial liver support system, the bioreactor serves as the core device to provide sufficient oxygen, appropriate nutrients and a suitable pH environment for the cell population, so that the cells can maximize their biological activity and achieve efficient expression of liver function. level of protection. [0003] At present, the bioartificial liver support system that has been used in clinical trials or treatments mainly includes three parts: p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/18
CPCA61M1/16A61M1/1621A61M1/1698A61M2202/0413A61M2202/0021
Inventor 周平刘路
Owner WUHAN TOGO MEDITECH CO LTD
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