Blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation and preparation method thereof

A hypoglycemic and microencapsulation technology, which is applied in the direction of microcapsules, capsule delivery, and pharmaceutical formulations, can solve problems such as incomplete extraction, and achieve the effects of improving resource utilization, improving taste, and excellent water dispersion and instant solubility

Active Publication Date: 2016-10-12
RIZHAO POLYTECHNIC
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  • Claims
  • Application Information

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Problems solved by technology

[0007] In order to achieve the above object, the present invention first uses Monascus to carry out fermentation cooperative extraction in the water system, and with the help of the complex enzyme system produced in the fermentation process of Monascus, on the one hand, the structure of fruiting body cells is destroyed, and the extraction efficiency is improved. On the other hand, the complex enzyme system produced can convert some low-polar components to improve their solubility in aqueous solution, so that more functional components can be leached out. Third, comprehensively use the bidirectional fermentation theory , make the efficacy of Monascus and Ganoderma lucidum synergistic, and give full play to the medicinal value of the two; after the fermentation, the separated fermentation residue is subjected to secondary leaching with ethanol solution, so that the low-polarity components are further released , overcame the technical problem of incomplete extraction by traditional methods, and realized the maximum enrichment of hypoglycemic components in Ganoderma lucidum; then, through multi-stage microencapsulation, the stability of functional components and their dissolution and release efficiency were improved. To ensure its full hypoglycemic activity, at the same time, the microencapsulation process can realize the sealing of the bitter groups in Ganoderma lucidum extract, so as to improve its oral palatability

Method used

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  • Blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation and preparation method thereof
  • Blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation and preparation method thereof
  • Blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0053] (1) Raw materials: Ganoderma lucidum fruiting body and spore powder for lowering blood sugar;

[0054] (2) Raw material pretreatment: the fruiting bodies of the hypoglycemic ganoderma lucidum are crushed into powders with a particle size of about 40 meshes, the hypoglycemic ganoderma spore powder is subjected to wall-breaking treatment, and the wall-breaking rate of the blood-sugar-lowering ganoderma lucidum is about 86%, and the blood-sugar-lowering ganoderma lucidum broken wall is obtained spore powder;

[0055] (3) Fermentation synergistic water extraction: take by weighing 1kg of the sugar-reducing Ganoderma lucidum fruiting body powder obtained in step (2), place it in a sterilized extraction tank, and sterilize it by ultraviolet irradiation; then add equivalent to Hypoglycemic Ganoderma lucidum fruiting body powder mass 10 times the sterilized citric acid aqueous solution (0.5%, w / v), and stir evenly, make fermentation base material; Activate good Monascus rubber ...

Embodiment 2

[0062] (1) Raw materials: Ganoderma lucidum fruiting body and spore powder for lowering blood sugar;

[0063] (2) Raw material pretreatment: Ganoderma lucidum fruiting body is crushed into a powder with a particle size of about 30 meshes, the ganoderma lucidum spore powder is subjected to wall-breaking treatment, and its wall-breaking rate is detected to be about 82%, and the blood-sugar-lowering ganoderma lucidum broken wall is obtained spore powder;

[0064] (3) Fermentation synergistic water extraction: take by weighing 1kg of sugar-reducing ganoderma lucidum fruiting body powder obtained in step (2), place it in a sterilized extraction tank, and utilize ozone sterilization to sterilize it; then add equivalent Add the sterilized aqueous citric acid solution (0.4%, w / v) of 6 times the mass of Ganoderma lucidum fruiting body powder for hypoglycemia, and stir evenly to make the fermentation base material; The inoculum is inoculated into the sterilized fermentation base materi...

Embodiment 3

[0071] (1) Raw materials: Ganoderma lucidum fruiting body and spore powder for lowering blood sugar;

[0072] (2) Raw material pretreatment: the fruiting body of the hypoglycemic ganoderma lucidum is crushed into a powder with a particle size of about 20 meshes, the hypoglycemic ganoderma spore powder is subjected to wall-breaking treatment, and the wall-breaking rate is detected to be about 91%, and the blood-sugar-lowering ganoderma lucidum broken wall is obtained spore powder;

[0073] (3) Fermentation synergistic water extraction: take by weighing the sugar-reducing ganoderma lucidum fruiting body powder that 50kg step (2) obtains, place in the sterilizing extraction tank, utilize ultraviolet radiation to carry out sterilization treatment to it; Then add equivalent to Hypoglycemic ganoderma lucidum fruiting body powder mass 15 times the sterilized citric acid aqueous solution (0.8%, w / v), and stir evenly, make the fermentation base; The inoculum is inoculated into the ste...

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Abstract

The invention discloses a blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation and a preparation method thereof. The method includes the specific steps of conducting monascus fermentation, water extraction, alcohol extraction, multi-stage micro-encapsulation, spray drying and granulating processes with blood-glucose-lowering ganoderma lucidum sporocarp and conidial powder as raw materials to prepare the blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation. The blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation prepared through the method brings the medicinal value of monascus and ganoderma lucidum into full play, functional components in blood-glucose-lowering ganoderma lucidum are efficiently enriched, the preparation process is green and mild, industrial production is easy, the obtained product has good water dispersity, storage stability and blood glucose lowering function, the use convenience of the product and the bioavailability in human bodies are effectively improved, guarantees are provided for development, application and consumption of the blood-glucose-lowering ganoderma lucidum product, and the preparation has great significance in promoting the development of the blood-glucose-lowering ganoderma lucidum industry and promoting the national health.

Description

technical field [0001] The invention belongs to the field of preparation of hypoglycemic ganoderma preparations, and specifically relates to a preparation method of a hypoglycemic ganoderma instant microencapsulated preparation, that is, a blood sugar-lowering ganoderma is used as a raw material, which is subjected to water extraction, alcohol extraction, multi-stage microencapsulation and co-fermentation A method for preparing hypoglycemic Ganoderma lucidum instant microencapsulated preparation by dry granulation. Background technique [0002] With the continuous improvement of people's living standards, the number of patients with hyperglycemia is increasing day by day. Diabetic complications and cardiovascular diseases caused by hyperglycemia seriously endanger human health. chronic non-communicable diseases. According to the World Health Organization and the International Diabetes Federation, by 2030, the total number of diabetic patients in the world will reach 366 mil...

Claims

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Application Information

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IPC IPC(8): A61K36/074A61K9/50A61P3/10
CPCA61K9/50A61K36/074A61K47/36A61K47/40A61K47/42A61K2236/19A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 周庆新林范亮周瑾若
Owner RIZHAO POLYTECHNIC
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