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Traditional Chinese medicine preparation for treating cold as well as preparation method and detection method thereof

A technology of traditional Chinese medicine preparations and preparations, which is applied in the direction of medical formulas, medical preparations containing active ingredients, pill delivery, etc. It can solve problems such as stomach discomfort, hard pills, and large dosages, and achieve control of safety and stability. Improve the extraction efficiency and ensure the effect of clinical efficacy

Active Publication Date: 2016-09-28
陕西开元制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The original preparation is a pill, which is made according to the process of powdering all medicinal materials with water. The pellets are hard, disintegrate slowly, and have poor bioavailability; taking large doses, patients often feel stomach discomfort after oral administration

Method used

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  • Traditional Chinese medicine preparation for treating cold as well as preparation method and detection method thereof
  • Traditional Chinese medicine preparation for treating cold as well as preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] (1) Get Chuan Fritillaria 36g, Poria cocos 24g, be pulverized into 120 mesh fine powders respectively, set aside;

[0061] (2) Take Asarum 24g and add 15 times of water to distill for 3 hours to obtain Asarum volatile oil, distillate and medicinal residues, and Asarum volatile oil is clathrated with β-cyclodextrin to obtain an inclusion compound;

[0062] (3) Get orange red 48g, schisandra 36g and reflux three times with 70% ethanol, solvent amount is respectively 8, 7, 8 times respectively, each 1.5 hours, merges three filtrates, reclaims ethanol under reduced pressure and when concentrated to 60 ℃, relative density is From 1.30 to 1.32, the alcohol-extracted concentrated extract was obtained, and the dregs were retained for use;

[0063] (4) get ephedra 880g and extract three times with 80% ethanol under reflux, the amount of solvent is 9, 9, 8 times respectively, each time for 1 hour, merge the filtrate three times, reclaim ethanol under reduced pressure and concentr...

Embodiment 2

[0067] (1) Get Fritillaria 24g and Poria cocos 16g, grind them into 120 mesh fine powder respectively, set aside;

[0068] (2) Take Asarum 16g and add 15 times of water to distill for 3 hours to obtain Asarum volatile oil, distillate and medicinal residues, and Asarum volatile oil is clathrated with β-cyclodextrin to obtain an inclusion compound;

[0069] (3) Get orange red 72g, schisandra 24g and reflux three times with 90% ethanol, solvent amount is respectively 8, 7, 8 times respectively, each 1.5 hours, merge three times filtrate, decompression reclaims ethanol and when concentrated to 60 ℃, relative density is From 1.30 to 1.32, the alcohol-extracted concentrated extract was obtained, and the dregs were retained for use;

[0070] (4) get ephedra 1320g and extract three times with 60% ethanol under reflux, the amount of solvent is 9, 9, 8 times respectively, each time for 1 hour, merge the filtrate three times, reclaim ethanol under reduced pressure and concentrate to 60 ℃...

Embodiment 3

[0074] (1) Get Fritillaria sichuanensis 30g and Poria cocos 20g, pulverize into 120 mesh fine powder respectively, set aside;

[0075] (2) Take 20 g of Asarum and add 15 times of water to distill for 3 hours to obtain Asarum volatile oil, distillate and medicinal residues, and Asarum volatile oil is clathrated with β-cyclodextrin to obtain an inclusion compound;

[0076] (3) get orange red 60g, schisandra 30g and reflux three times with 80% ethanol, solvent amount is respectively 8, 7, 8 times, each time 1.5 hours, merge three times of filtrate, decompression reclaims ethanol and when concentrated to 60 ℃, relative density is From 1.30 to 1.32, the alcohol-extracted concentrated extract was obtained, and the dregs were retained for use;

[0077] (4) get ephedra 1100g and extract three times with 70% ethanol under reflux, the amount of solvent is 9, 9, 8 times respectively, each time for 1 hour, merge the filtrate three times, reclaim ethanol under reduced pressure and concentr...

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Abstract

The invention relates to a traditional Chinese medicine preparation for treating cold as well as a preparation method and a detection method thereof. The traditional Chinese medicine preparation is prepared from the following crude drugs in parts by weight: 48 to 72 parts of tangerine peels, 880 to 1320 parts of Chinese ephedra herb, 112 to 168 parts of radix platycodonis, 24 to 36 parts of bulbus fritillariae uninbracteatae, 24 to 36 parts of fructus schisandrae chinensi, 16 to 24 parts of poria cocos, 16 to 24 parts of herba asari, 112 to 168 parts of chloriti lapis and 28 to 42 parts of liquorice roots. The detection method comprises qualitative detection of hyphae, the fructus schisandrae chinensi, aurantiamarin and the like and quantitative detection of aristolochic acid and ephedrine hydrochloride. According to the traditional Chinese medicine preparation, an improvement process is carried out so that the effect is more remarkable, the dose is reduced and the traditional Chinese medicine preparation is more convenient to take and carry, is rapidly released, is rapid in absorption and has higher bioavailability.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine preparation for treating colds, a preparation method and a detection method thereof. Background technique [0002] Cold is a kind of modal respiratory disease, and the traditional Chinese medical science is divided into cold by wind-cold type cold, wind-heat type cold, summer-dampness type cold and seasonal common cold four types. According to the principle of treating based on syndrome differentiation, different types of colds should be treated with different Chinese patent medicines. Among them, wind-cold cold is caused by the attack of wind-cold evil and loss of lung energy, and it usually occurs frequently in autumn and winter. The treatment method is mainly based on pungent and warming to relieve the exterior, often using ephedra, Nepeta, Fangfeng, Perilla and other anti-exterior and cold-dispelling medicines....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61P11/00G01N30/90G01N30/88A61K33/26
CPCA61K9/1652A61K9/2059A61K9/4866A61K33/26A61K36/076A61K36/17A61K36/268A61K36/346A61K36/484A61K36/57A61K36/752A61K36/79A61K36/8966A61K2236/331A61K2236/333A61K2236/39A61K2236/51G01N30/88G01N30/90G01N2030/027G01N2030/8809A61K2300/00
Inventor 刘宏伟袁莉
Owner 陕西开元制药有限公司
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