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Preparation method of sulfonated polypropylene non-woven fabric anticoagulation material

A sulfonated polypropylene, non-woven technology, used in anticoagulant treatment, textiles and papermaking, packaging types, etc., can solve the problem of low blood compatibility, poor anticoagulation performance, unstable properties, etc. problems, to achieve significant anticoagulant activity, good anticoagulant properties, and no solvent toxicity

Inactive Publication Date: 2016-09-21
袁春华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem mainly solved by the present invention: the current anticoagulant biomaterials have poor anticoagulant performance, short-lasting time, unstable properties and easy oxidation, and low compatibility with blood, which makes blood maintenance more difficult etc., the present invention discloses a preparation method of sulfonated polypropylene non-woven fabric anticoagulant material; the present invention uses konjac fine powder as raw material, undergoes ultrasonic dispersion and extraction, then precipitates with absolute ethanol, centrifuges, and then The filtrate was ultrafiltered, subjected to alcohol precipitation for the second time, combined and precipitated, vacuum freeze-dried, and then reacted with a sulfated agent to adjust the pH to obtain sulfated konjac glucomannan, and then irradiated the grafted poly The propylene non-woven fabric is soaked in the sulfated konjac glucomannan solution to obtain the sulfonated polypropylene non-woven anti-coagulant material. The anti-coagulant material of the present invention has good compatibility with blood, and the anti-coagulant The life span is prolonged, the storage time of blood can be extended by 2 to 4 weeks, and the incidence of thrombosis is reduced by 40 to 60%, which has a good application prospect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0018]First weigh 50g of konjac fine powder, add 1~2L of deionized water, disperse with 300W ultrasonic wave for 15min, transfer to a centrifuge, centrifuge at 3000r / min for 10min, collect the supernatant, wash the residue twice with deionized water, The washing liquid was merged into the supernatant to obtain the extract of konjac fine powder; the above-mentioned konjac fine powder extract was added to 1L of absolute ethanol, ultrasonicated under 500W ultrasonic wave for 5min, after standing for 6h, transferred to a centrifuge, and heated at 3000rr. Centrifuge at 0.2 MPa for 10 min to collect the precipitate. Use an ultrafiltration membrane with a molecular weight cut-off of 80,000 Daltons to filter the supernatant until the retentate is 20% of the volume of the original solution. Add 400 mL of ethanol with a mass fraction of 95%. In the solution, sonicate for 5 minutes under 500W ultrasonic wave, let it stand for 6 hours, transfer it to a centrifuge for centrifugation, collec...

example 2

[0021] First, weigh 65g of konjac fine powder, add it to 1.5L deionized water, disperse it with 300W ultrasonic wave for 17min, transfer it to a centrifuge, and centrifuge it at 3500r / min for 12min, collect the supernatant, wash the residue with deionized water 2.5 times, wash liquid into the supernatant to obtain the konjac fine powder extract; add the above konjac fine powder extract to 1.5L absolute ethanol, ultrasonicate for 7min under 500W ultrasonic waves, leave it for 7h, then transfer to a centrifuge, and Centrifuge at 0.35 MPa for 13 min to collect the precipitate. The supernatant is ultrafiltered at 0.35 MPa until the retentate is 22% of the volume of the original solution. Add 600 mL of ethanol with a mass fraction of 95%. In the solution, sonicate for 7 minutes under 500W ultrasonic wave, let it stand for 7 hours, transfer it to a centrifuge for centrifugation, collect the precipitate and combine it with the previous precipitate, and freeze-dry it in a vacuum freeze...

example 3

[0024] First, weigh 80g of konjac fine powder, add it into 2L of deionized water, disperse it with 300W ultrasonic wave for 20min, transfer it to a centrifuge, and centrifuge at 4000r / min for 15min, collect the supernatant, wash the residue 3 times with deionized water, and wash the liquid Merge into the supernatant to obtain the konjac fine powder extract; add the above konjac fine powder extract to 2L of absolute ethanol, ultrasonicate for 10min under a 500W ultrasonic wave, leave it for 8h, then transfer it to a centrifuge, and heat it at 4000r / min Centrifuge for 15 minutes to collect the precipitate. The supernatant is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 100,000 Daltons at 0.5 MPa until the retained solution is 25% of the volume of the original solution, and added to 800 mL of 95% ethanol solution. , sonicate under 500W ultrasonic wave for 10min, let it stand for 8h, transfer it to a centrifuge for centrifugation, collect the pr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Abstract

The invention discloses a preparation method of a sulfonated polypropylene non-woven fabric anticoagulant material, which belongs to the technical field of anticoagulant material preparation. The present invention uses konjac powder as a raw material, which is dispersed and extracted by ultrasonic waves, then precipitated with absolute ethanol, centrifuged, and the filtrate is ultrafiltered, subjected to secondary alcohol precipitation, combined and precipitated, vacuum freeze-dried, and then reacted with sulfuric acid esterification react with reagents, adjust the pH to obtain sulfated konjac glucomannan, and then soak the polypropylene non-woven fabric that has been irradiated and grafted in the sulfated konjac glucomannan solution to obtain sulfonated polypropylene non-woven fabrics. Spun anticoagulant material, the anticoagulant material of the present invention has good compatibility with blood, the life of anticoagulant is prolonged, the storage time of blood can be extended by 2-4 weeks, the incidence of thrombus is reduced by 40-60%, and there is Good application prospects.

Description

technical field [0001] The invention discloses a preparation method of a sulfonated polypropylene non-woven fabric anticoagulant material, which belongs to the technical field of anticoagulant material preparation. Background technique [0002] Biomaterials are a class of materials that can be used for the repair and replacement of animal organs and tissues, diagnosis and treatment of diseases, are biocompatible with animals, and have special properties or functions. Anticoagulant biomaterials are an important part of biomaterials and are widely used in medical materials in contact with human blood and tissues, such as hemodialysis systems, extracorporeal circulation systems, artificial heart valves, cardiac pacemakers, artificial blood vessels, Vascular stents, surgical wires and catheters, etc. When foreign matter comes into contact with blood, it will destroy red blood cells, activate and aggregate platelets, and form thrombus. At present, in clinical practice, there is...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Application Information

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IPC IPC(8): D06M15/03D06M14/28C08B37/02A61L33/00A61L33/18D06M101/20
CPCD06M15/03A61L33/0011A61L33/0088A61L33/18C08B37/0003C08B37/009D06M14/28D06M2101/20
Inventor 袁春华王龙陆娜
Owner 袁春华
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