Hydroxychloroquine sulfate and polyglutamic acid polymer, as well as preparation method and application thereof

Abstract

The invention discloses a hydroxychloroquine sulfate and polyglutamic acid polymer, as well as a preparation method and application thereof. The hydroxychloroquine sulfate and polyglutamic acid polymer is a polymer formed by carrying out esterification reaction between hydroxychloroquine sulfate and polyglutamic acid according to a weight ratio of 1:(1-6). The hydroxychloroquine sulfate and polyglutamic acid polymer is applied to treatment of discoid lupus erythematosus and systemic lupus erythematosus. The hydroxychloroquine sulfate and the polyglutamic acid are cross-linked to obtain the hydroxychloroquine sulfate and polyglutamic acid polymer, and hydroxyls of the hydroxychloroquine sulfate are modified to change certain original physiochemical properties thereof, improve pharmaceutical activity, enhance curative effects, reduce side effects, improve the sustained release effects of the drug and reduce the medication frequency of a patient; when the hydroxychloroquine sulfate and polyglutamic acid polymer is used for treating discoid lupus erythematosus and systemic lupus erythematosus, the drug can reach a destination lesion location under protection of the polyglutamic acid in a slow degradation process, so that the aim of accurate treatment is fulfilled, and the hydroxychloroquine sulfate and polyglutamic acid polymer has a certain clinical application value.

Description

technical field [0001] The invention relates to the technical field, in particular to a hydroxychloroquine sulfate polyglutamic acid polymer and a preparation method and application thereof. Background technique [0002] Hydroxychloroquine sulfate, medicine, the main component is 2-4-(7-chloro-4-quinolyl) aminopentylethylamino-ethanol sulfate. It is a film-coated tablet, which is white or off-white after the coating is removed. For the treatment of discoid lupus erythematosus and systemic lupus erythematosus. [0003] Hydroxychloroquine sulfate may have the following reactions during long-term treatment, but the adverse reactions of different compounds and their types and incidence may be different. (1) Central nervous system reactions: excitement, nervousness, mood changes, nightmares, psychosis, headache, dizziness, vertigo, tinnitus, nystagmus, nervous deafness, convulsions, ataxia. (2) Neuromuscular reactions: external ophthalmoplegia, skeletal muscle weakness, and de...

AI Technical Summary

Problems solved by technology

For example, the unsatisfactory pharmacokinetic properties affect the absorption of drugs, resulting in low bioavailability, or the metabolic rate is too fast or too slow due to the characteristics of the chemical structure; Side effects; there are some other reasons, such as poor chemical stability, poor solubility, bad smell or taste, irritation or pain to the body, etc.