Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition of vesalium and medical application thereof

A technology of haloperidol and its composition, which is applied in the field of haloperidol pharmaceutical composition, can solve problems such as weak sedative effect, and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2016-08-31
黄芳
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antiemetic effect is also strong, but the sedative effect is weak

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition of vesalium and medical application thereof
  • Pharmaceutical composition of vesalium and medical application thereof
  • Pharmaceutical composition of vesalium and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0020] Separation method: (a) Grind Magnolia officinalis (2kg), extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L×3 times) ), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a ) in the ethyl acetate extract with D101 type macroporous resin to remove impurities, first elute 8 column volumes with 25% ethanol, then elute 12 column volumes with 70% ethanol, collect 70% eluate, and concentrate under reduced pressure Obtain 70% ethanol elution concentrate; (c) in step (b), 70% ethanol elution concentrate is separated with normal phase silica gel, is 85:1 (10 column volumes), 45:1 (8 column volumes) successively with volume ratio column volume), 25:1 (10 column...

Embodiment 2

[0023] Embodiment 2: pharmacological action

[0024] In this example, a rat model of kidney-qi deficiency asthma was prepared by panic stimulation, and the drug's anti-kidney-qi-deficiency asthma effect was observed in terms of increasing serum T4, COR, and T value levels.

[0025] 1. Materials and methods

[0026] 1.1 Animals

[0027] Clean-grade male Wistar rats, body weight (74.40±4.95) g, aged 5 weeks, were purchased from Shanghai Slack Experimental Animal Co., Ltd. They were reared at a constant temperature with a humidity of 50% to 60%, the temperature was kept at (20±1)°C, the light alternated between light and dark every 12 hours, the ventilation was 8 to 15 times per hour, and the whole nutrition granules provided by the Experimental Animal Center of Zhejiang University of Traditional Chinese Medicine were eaten. Adaptive feeding for 1 week.

[0028] 1.2 Reagents and samples

[0029] Haloperidol was purchased from China National Institute for the Control of Pharma...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a pharmaceutical composition of vesalium and medical application thereof. The pharmaceutical composition of vesalium contains vesalium and a novel-structure natural product compound (I). The glibenclamide and compound (I) can restore the serum indexes of the kidney-qi deficiency asthma model to normal and has the function of treating kidney-qi deficiency asthma when being independently used. The combination of the vesalium and compound (I) further enhances the treatment effects, and can be developed into drugs for treating the kidney-qi deficiency asthma. Compared with the prior art, the pharmaceutical composition has outstanding substantial characteristics and marked progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of haloperidol, in particular to a pharmaceutical composition of haloperidol and its medical application. Background technique [0002] Haloperidol is the main representative of butyrophenone antipsychotics, its effect is similar to that of chlorpromazine, and it has strong dopamine receptor antagonistic effect. At the same dose, its dopamine receptor antagonism effect is 20 to 40 times that of chlorpromazine, so it is a powerful low-dose antipsychotic. Features: anti-anxiety and antipsychotic effects are strong and long-lasting, and are effective for manic symptoms of schizophrenia and other psychosis. The antiemetic effect is also strong, but the sedative effect is weak. The cooling effect is not obvious. The anticholinergic and anti-NA effects are weak, and there are few adverse reactions in the cardiovascular system. Contents of the invention [0003] The objec...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07J71/00A61K31/585A61K31/4515A61P11/06
CPCC07J71/0005A61K31/4515A61K31/585
Inventor 黄芳
Owner 黄芳
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com