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Pharmaceutical composition and its preparation method and use

A composition and drug technology, applied in the field of medicine, can solve the problems of high treatment costs and limited DFU treatment options, and achieve the effects of no toxic side effects, obvious therapeutic effects, and low recurrence rate of symptoms

Active Publication Date: 2016-08-31
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The only approved effective treatment for DFU is the topical gel formulation of platelet-derived growth factor Regranex, but treatment is expensive
Therefore, treatment options for DFU are limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Weigh adenosine 10g, glycine 35g, uracil 20g, serine 20g, tryptophan 5g, adenine 30g, arginine 15g, glutamic acid 18g, alanine 10g, dopamine 15g, add appropriate amount of water for injection to dissolve , add 100ml of glycerin, 2g of sodium benzoate, stir to dissolve, add water for injection to 1000ml, adjust the pH to 5.5-7.5, filter, and sterilize the filtrate at 115°C for 30min to obtain the product.

Embodiment 2

[0029] Weigh 10g of adenosine, 35g of glycine, 20g of uracil, 20g of serine, 5g of tryptophan, 30g of adenine, 15g of arginine, 18g of glutamic acid, 10g of alanine, and 15g of dopamine. After mixing evenly, add 100g of starch 1. 80g sodium carboxymethyl starch, after mixing evenly, granulate, then add 3g of micropowder silica gel, after mixing evenly, directly compress into tablets to obtain final product.

Embodiment 3

[0031] Weigh adenosine 10g, glycine 35g, uracil 20g, serine 20g, tryptophan 5g, adenine 30g, arginine 15g, glutamic acid 18g, alanine 10g, dopamine 15g, add appropriate amount of water for injection to dissolve, Then slowly add to the gel matrix containing 10g carbomer 934, 120g glycerol, 1g ethylparaben, 4g sodium hydroxide, 2g polysorbate 80 and an appropriate amount of water for injection, add water for injection to 1000g, and extinguish at 115°C. Sterilize for 30 minutes, pack, and obtain the gel.

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PUM

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Abstract

The invention provides a pharmaceutical composition and its preparation method and use. The pharmaceutical composition comprises, by weight, 1-15 parts of adenosine, 20-40 parts of adenine, 10-25 parts of uracil, 10-28 parts of serine, 1-10 parts of tryptophan, 20-35 parts of adenine, 8-25 parts of arginine, 10-26 parts of glutamic acid, 1-15 parts of alanine and 10-25 parts of dopamine. The pharmaceutical composition has substantial treatment effects on irritable bowel syndrome, ulcerative colitis, gastric ulcer, peptic ulcer, diabetic foot ulcer, gastrointestinal motility disorder, eczema, anal fissure, gastroesophageal reflux disease and fungal infection, has no toxic or side effect, has high safety and has a low recurrence rate.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition and its preparation method and application. Background technique [0002] Peptic ulcer mainly refers to chronic ulcers that occur in the stomach and duodenum, and can also occur in the lower esophagus, around the gastrojejunostomy, and Meckel's diverticulum containing ectopic gastric mucosa. A large number of studies have fully proved that Helicobacter pylori infection is the main cause of peptic ulcer. Its clinical manifestation is epigastric pain, often presents dull pain, dull pain, distending pain, burning pain. The pain of gastric ulcer usually occurs within 1 hour after a meal, and gradually relieves after 1 to 2 hours, and the above rhythm reappears until the next meal. Some patients may be asymptomatic, or have complications such as bleeding and perforation as the first symptom. Ulcer disease is a chronic common disease, and it is difficult to treat...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61K31/52A61K31/513A61K31/198A61K31/405A61K31/137A61P1/04A61P1/14A61P17/00A61P31/10
CPCA61K31/137A61K31/198A61K31/405A61K31/513A61K31/52A61K31/7076A61K2300/00
Inventor 耿福能
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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