Preparation method and application of copper sulfide nanocapsule particle

A technology of nano-capsules and copper sulfide, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, capsule delivery, etc., can solve the problems of limited practical application, no copper sulfide, complicated steps, etc., and achieves good results. The effect of drug loading, less energy consumption, and simple equipment

Inactive Publication Date: 2016-08-31
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the synthesis method is cumbersome and the yield is low, which seriously limits its practical application.
At present, there are many reports on copper sulfide as a light-to-heat conversion material, but there are few reports on copper sulfide itself as a drug carrier.

Method used

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  • Preparation method and application of copper sulfide nanocapsule particle
  • Preparation method and application of copper sulfide nanocapsule particle
  • Preparation method and application of copper sulfide nanocapsule particle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Weigh 0.3mmol of L-cysteine ​​and dissolve in 150mL double distilled water, 0.4mmol of Cu(NO 3 ) 2 ·3H 2 O was dissolved in 50mL double distilled water, dissolved evenly, and Cu(NO 3 ) 2 Add the solution dropwise to the lysine solution, stir with a magnetic stirrer at room temperature for 30 minutes; weigh 0.3mmol of Na 2 S 2 o 3 Dissolve in 2mL double-distilled water, dissolve evenly, add dropwise to the above mixture, the mixture turns dark brown; heat the above solution to 90°C and react for 120min; after the reaction, centrifuge at 5000rpm for 10min, wash with double-distilled water for 3 times, and dry to obtain Black precipitate.

[0035] Prepare the obtained black precipitates into 0.125, 0.25, 0.5, and 1mg / mL CuS-Cy solutions respectively, and use 1W / cm 2 The power is irradiated for 6 minutes, and the temperature change is tested every 10 seconds. Dissolve 5 mg of CuS-Cy nanocapsules in 10 mL of PBS, stir evenly, add 5 mg DOX and dissolve in the above so...

Embodiment 2

[0041] Weigh 0.2mmol of L-cysteine ​​and dissolve in 150mL double distilled water, 0.4mmol of Cu(NO 3 ) 2 ·3H 2 O was dissolved in 50mL double distilled water, dissolved evenly, and Cu(NO 3 ) 2 Add the solution dropwise to the lysine solution, stir with a magnetic stirrer at room temperature for 30 minutes; weigh 0.3mmol of Na 2S 2 o 3 Dissolve in 2mL double-distilled water, dissolve evenly, add dropwise to the above mixture, the mixture turns dark brown; heat the above solution to 90°C and react for 120min; after the reaction, centrifuge at 5000rpm for 10min, wash with double-distilled water for 3 times, and dry to obtain The black precipitate is copper sulfide nanocapsule particles.

[0042] The properties of the copper sulfide nanocapsule particles prepared in this example are similar to those in Example 1, and will not be repeated here.

Embodiment 3

[0044] Weigh 0.1mmol of L-cysteine ​​and dissolve in 150mL double distilled water, 0.4mmol of Cu(NO 3 ) 2 ·3H 2 O was dissolved in 50mL double distilled water, dissolved evenly, and Cu(NO 3 ) 2 Add the solution dropwise to the lysine solution, stir with a magnetic stirrer at room temperature for 60 minutes; weigh 0.3mmol of Na 2 S 2 o 3 Dissolve in 2mL double-distilled water, dissolve evenly, add dropwise to the above mixture, the mixture turns dark brown; heat the above solution to 90°C and react for 120min; after the reaction, centrifuge at 5000rpm for 10min, wash with double-distilled water for 3 times, and dry to obtain The black precipitate is copper sulfide nanocapsule particles.

[0045] The properties of the copper sulfide nanocapsule particles prepared in this example are similar to those in Example 1, and will not be repeated here.

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Abstract

The invention discloses a preparation method of a copper sulfide nanocapsule particle. The method includes the steps of: (1) weighing L-cysteine and Cu(NO3)2.3H2O, and dissolving them in double-distilled water respectively; (2) adding a Cu(NO3)2 solution into the L-cysteine solution dropwise, and performing stirring at room temperature to obtain a mixed solution; (3) weighing Na2S2O3 and dissolving it in double-distilled water evenly to obtain an Na2S2O3 solution, and adding the Na2S2O3 solution into the mixed solution dropwise to obtain a dark brown mixed solution; (4) subjecting the dark brown mixed solution to reaction at 80-100DEG C; and (5) at the end of the reaction, carrying out centrifugation, washing and drying to obtain black precipitate, i.e. the copper sulfide nanocapsule particle. The copper sulfide nanocapsule particle prepared by the method provided by the invention has a uniform capsule-shaped structure, the preparation temperature is low, energy is saved, and the process is simple.

Description

technical field [0001] The invention relates to copper sulfide nanomaterials, in particular to a preparation method and application of copper sulfide nanocapsule particles. Background technique [0002] Tumor has become an important disease that threatens human health and death. Traditional treatment methods such as surgery, chemotherapy, and radiotherapy have certain shortcomings, such as killing normal cells and cancer cells at the same time, reducing human immunity, and chemotherapy is prone to multidrug resistance. It cannot fully meet the needs of cancer treatment and development. New treatments are urgently needed to be developed. Among them, the development of nanomaterials and technologies provides more opportunities for tumor combination therapy. Photothermal therapy uses photothermal materials to convert their absorption in the near-infrared region into heat, and kills tumors through local high temperature. It has the characteristics of rapidity, high efficiency ...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/02A61K47/48A61K31/704A61P35/00
CPCA61K9/5115A61K31/704
Inventor 李丽华王丽平彭明营
Owner SOUTH CHINA UNIV OF TECH
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