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Carboxymethyl lysine fluorescence imprinting material and preparing method and application thereof

A technology of carboxymethyl lysine and imprinting material, which is applied in the field of carboxymethyl lysine fluorescent imprinting material and preparation thereof, can solve the problems of unfavorable real-time detection, high detection cost, complicated processing and the like, and achieves good practicability, Strong specificity and the effect of increasing adsorption efficiency

Inactive Publication Date: 2016-08-10
BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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  • Abstract
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AI Technical Summary

Problems solved by technology

The combination of large-scale instruments can accurately detect carboxymethyllysine residues, but the disadvantages are complex sample pretreatment, time-consuming, high detection cost, professional operation is required, and expensive large-scale instruments are required, which is not conducive to instant detection

Method used

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  • Carboxymethyl lysine fluorescence imprinting material and preparing method and application thereof
  • Carboxymethyl lysine fluorescence imprinting material and preparing method and application thereof
  • Carboxymethyl lysine fluorescence imprinting material and preparing method and application thereof

Examples

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Embodiment 1

[0027] This example provides a preparation method and application of a fluorescent imprinting material enriched with trace amounts of carboxymethyllysine, including the following steps:

[0028] 1) Precursor preparation of carboxymethyllysine fluorescent imprinting material: 180 mL of Triton X-100 and 7.5 mL of cyclohexane were magnetically stirred at room temperature for 15 minutes, and 3 mg of CdSe / ZnS quantum dots were added. Add 50 μL of tetraethoxysilane and 100 μL of 25% ammonia solution and continue stirring for 2 h. Add 19 μL of 3-aminopropyltriethoxysilane, 100 μL of an aqueous solution of carboxylated graphene at a concentration of 2 mg / mL, 0.4 mg of the template molecule carboxymethyllysine, seal it, and stir at room temperature 20 hours. After the polymerization reaction, first wash the prepared product with acetone, perform centrifugation, remove the supernatant, redisperse it in deionized water, perform centrifugation again, and remove the supernatant again to o...

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Abstract

The invention discloses a carboxymethyl lysine fluorescence imprinting material and a preparing method and application thereof .According to the preparing method, thin layer nano material graphene is used as a carrier, a fluorescence nano material namely quantum dots excellent in optical performance is used as a response element, a molecularly imprinting polymer high in selectivity and specificity is used as a recognition element, an efficient, portable, fast and sensitive molecularly imprinting fluorescence sensing system is set up, carboxymethyl lysine is used as template molecules, 3-aminopropyl triethoxy silane is used as a functional monomer, tetraethoxy-silicane is used as a crosslinking agent, and ammonia water is used as a catalyst .The surface molecularly imprinting material based on graphene and quantum dots is prepared through a reversed-phase microemulsion synthesis method, and carboxymethyl lysine residues can be detected from food fast and easily .

Description

technical field [0001] The invention belongs to the research field of optical imprinting material preparation technology and food safety detection method, and in particular relates to a carboxymethyllysine fluorescent imprinting material and its preparation method and application. Background technique [0002] Carboxymethyllysine is one of the most studied advanced glycation end products, and is often used as a marker for the formation of advanced glycation end products in food. Carboxymethyl lysine is very stable and often exists in a complex form. The complex carboxymethyl lysine is usually composed of reducing sugar oxidation products or lipid peroxidation products in polypeptides or protein formation. A large number of medical studies have proved that carboxymethyllysine has certain toxicity, and its accumulation in the body is closely related to the pathogenesis of some chronic degenerative diseases such as diabetes, kidney disease, and atherosclerosis, and it will als...

Claims

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Application Information

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IPC IPC(8): G01N21/64
CPCG01N21/6486
Inventor 刘慧琳王静
Owner BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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