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Slow-release nano drug carrier as well as preparation method and application thereof

A nano-drug carrier and sustained-release technology, used in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve problems such as side effects and reduced drug availability, and achieve the effect of improving the sustained-release effect.

Active Publication Date: 2016-08-10
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Nanomicelle drug carriers have a common problem, that is, the drug release process, that is, during the drug release process, about 30% of the drug will be released in the first 8 hours, and the intravenously injected drug carrier is in the blood circulation in the body at this time And it is not enriched in a large amount in tumor tissue, which will lead to the reduction of drug availability and certain side effects

Method used

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  • Slow-release nano drug carrier as well as preparation method and application thereof
  • Slow-release nano drug carrier as well as preparation method and application thereof
  • Slow-release nano drug carrier as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Distill 100mg from P(MEO 2 The nanomicelles formed by MA-co-OEGMA-co-DMAEMA)-b-PLGA) were added to the Tris buffer solution of pH 8.5, and the concentration of Tris after adding was 10mmol / L. Add 50 mg of dopamine, react for 24 hours, and centrifuge at 60,000 rpm to obtain slow-release nano drug carrier.

[0027] Among them, P(MEO 2 The weight average molecular weight of MA-co-OEGMA-co-DMAEMA)-b-PLGA) is 16.4kDa; the structure of micelles is W / O / W; the size of the slow-release nano drug carrier is about 100nm.

Embodiment 2

[0029] Distill 100mg from P(MEO 2 The nanomicelles formed by MA-co-OEGMA-co-DMAEMA)-b-PLGA) were added to the Tris buffer solution of pH 7.5, and the concentration of Tris after adding was 1 mmol / L. Then add 10 mg of dopamine, react for 4 hours, and centrifuge at 10,000 rpm to obtain slow-release nano drug carrier.

[0030] Among them, P(MEO 2 The weight-average molecular weight of MA-co-OEGMA-co-DMAEMA)-b-PLGA) is 16.4kDa; the size of the slow-release nano drug carrier is about 100nm.

Embodiment 3

[0032] Distill 10mg from P(MEO 2 The nanomicelles formed by MA-co-OEGMA-co-DMAEMA)-b-PLGA) were added to the Tris buffer solution of pH 10.5, and the concentration of Tris after adding was 20mmol / L. Add 100 mg of dopamine, react for 48 hours, and centrifuge at 100,000 rpm to obtain sustained-release nano drug carrier.

[0033] Among them, P(MEO 2 The weight-average molecular weight of MA-co-OEGMA-co-DMAEMA)-b-PLGA) is 16.4kDa; the size of the slow-release nano drug carrier is about 100nm.

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Abstract

The invention provides a slow-release nano drug carrier as well as a preparation method and application thereof. The slow-release nano drug carrier is nano particles obtained by adsorbing polydopamine to the surface of a nano micelle which is formed by a poly(2-methyl-2-acrylic acid-2-(2-methoxyethoxy) ethyl ester-co-oligo-ethylene glycol methyl ether methacrylate-co-dimethylaminoethyl methacrylate-poly(lactic acid-co-glycolic acid) block copolymer, and the size of the nano particles is 50-1000nm. According to the slow-release nano drug carrier provided by the invention, polydopamine is wrapped on the surface of the micelle by adhesion to form a layer of slow-release film which can improve the slow-release effect of drugs carried in the micelle, so that the slow-release nano drug carrier has a certain application potential.

Description

technical field [0001] The invention belongs to the field of nano-biomedicine, and in particular relates to a slow-release nano drug carrier and its preparation method and application. Background technique [0002] Nanomicelle drug carriers have a common problem, that is, the drug release process, that is, during the drug release process, about 30% of the drug will be released in the first 8 hours, and the intravenously injected drug carrier is in the blood circulation in the body at this time And it is not enriched in a large amount in the tumor tissue, which will lead to the reduction of drug availability and certain side effects. Polydopamine (PDA) has recently become a drug carrier material with development potential, which has four significant advantages: first, it can be attached to the surface of almost all materials to form a film; second, the surface of the formed film contains a large number of active substances. Functional groups can undergo a series of reactions...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K9/51A61K9/127A61K31/704A61K31/337A61P35/00
CPCA61K9/1273A61K9/5146A61K31/337A61K31/704
Inventor 吴雁聂广军苏世帅
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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