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Bionic vascular stent and preparation method thereof

A biomimetic blood vessel, bare stent technology, applied in the fields of polymer materials and biomedical engineering, can solve the problems of bleeding risk, the stent is difficult to heal well with the blood vessel wall, etc., to promote endothelialization, good curative effect and long-term safety, inhibiting The effect of vascular restenosis

Inactive Publication Date: 2016-08-03
山东百多安医用材料改性工程技术中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the degradation and release of the polymer, the drug greatly inhibits the proliferation of the intima of the cells, which reduces the problem of restenosis after stent implantation, and also leads to the reduction of cell creeping skin, which makes it difficult for the stent to heal well with the vessel wall.
Although prolonging the course of dual antiplatelet therapy may reduce the occurrence of late thrombosis in the stent, it also brings the risk of bleeding

Method used

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  • Bionic vascular stent and preparation method thereof
  • Bionic vascular stent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Example 1: In this example, 316L stainless steel bare coronary stents were selected, cleaned by ultrasonic waves, and then dried for later use; 3.0 g of formazan 2-methacryloyloxyethyl phosphorylcholine was taken and dissolved in 8.6 g of ethyl methacrylate , add photoinitiator 0.01g, and irradiate under ultraviolet light for about 5 minutes to make the reaction complete.

[0024] Take 0.05 g of the product of the above reaction and 0.05 g of lactic acid-glycolic acid copolymer, dissolve them in an appropriate solvent, spray the mixture on the inner surface of the stent lumen by ultrasonic spraying, dry at room temperature for 12 hours, and then vacuum dry for 24 hours. The dried bare stent was placed in 500 μg / ml REDV solution, reacted at room temperature for 24 hours and then taken out to dry; using a special process, an asymmetric drug-loaded degradable polymer coating was prepared on the outer surface of the stent.

Embodiment 2

[0025] Example 2: In this example, degradable polylactic acid stents were selected, cleaned by ultrasonic waves and dried for later use; 3.0 g of glycerol phosphorylcholine was taken, 0.01 g of initiator, 0.005 g of catalyst, 15 g of lactide, and 5 g of glycolide were added. After vacuuming, seal the tube and polymerize for 16 hours, then take it out and purify it for later use.

[0026] Take 0.05 g of the product of the above reaction and 0.05 g of lactic acid-glycolic acid copolymer, dissolve them in an appropriate solvent, spray the mixture on the inner surface of the stent lumen by ultrasonic spraying, dry at room temperature for 12 hours, and then vacuum dry for 24 hours. The dried stent was placed in 500 μg / ml REDV solution, reacted at room temperature for 24 hours, and then taken out to dry; using a special process, an asymmetric drug-loaded degradable polymer coating was prepared on the outer surface of the stent.

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Abstract

The invention belongs to the field of high polymer materials and biomedical engineering, and particularly relates to a bionic vascular stent and a preparation method thereof. The bionic vascular stent comprises a bare stent for supporting, a drug-loaded degradable polymer coating, and a polymer coating containing a phosphorylcholine group and an Arg-Clu-Asp-Val (REDV) polypeptide (or molecules, capable of specifically combining endothelial cells and endothelial progenitor cells, of a CD34 antibody, a CD133 antibody and the like). The stent is applied to a vascular disease position; the degradable polymer coating on the outer wall of the stent gradually releases the loaded drug and inhibits vascular smooth muscle proliferation to prevent vascular restenosis after the stent is implanted; the polarity of the stent platform can be changed by the phosphorylcholine group in the coating at the inner side of the stent; the biocompatibility of the stent surface is improved; adhesive growth of the endothelial cells and the endothelial progenitor cells can be promoted by specific recognition sites of the endothelial cells / endothelial progenitor cells of REDV and the like; and the endothelialization progress of the stent surface is accelerated.

Description

technical field [0001] The invention belongs to the fields of polymer materials and biomedical engineering, and in particular relates to a bionic vascular stent and a preparation method thereof. Background technique [0002] Coronary atherosclerotic heart disease is a heart disease caused by atherosclerotic lesions in the coronary arteries that cause stenosis or blockage of the vessel lumen, resulting in myocardial ischemia, hypoxia or necrosis. It is often called "coronary heart disease". Published in "The Lancet" in 2013, the Burden of Disease Study in China showed that the top three causes of death in the Chinese population were stroke, ischemic heart disease and chronic obstructive pulmonary disease, among which the top two accounted for all cardiovascular diseases (including cerebrovascular diseases) ), so cardiovascular disease is a serious challenge to China's public health and health undertakings. [0003] At present, the most effective treatments for coronary heart...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/02A61L31/16A61L31/14
CPCA61L31/022A61L31/10A61L31/14A61L31/16A61L2300/416C08L67/04C08L89/00C08L43/02
Inventor 张海军钱菊英鲁守涛沈雳周超尹玉霞葛均波王身国杨飞
Owner 山东百多安医用材料改性工程技术中心
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