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Indapamide-containing medicine composition for treating hypertension and preparation method thereof

The technology of indapamide and composition is applied in the field of pharmaceutical composition for treating hypertension and its preparation field, which can solve the problems such as restricting the use of indapamide, and achieve the effects of improving therapeutic effect, small side effects and avoiding adverse reactions.

Inactive Publication Date: 2016-07-27
JINAN BANGWEN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This adverse reaction limits the clinical use of indapamide

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0039] Indapamide 2.5g, plantain head 3000g, white uncaria 3000g, fukien cypress 3000g, shepherd's head 3000g.

[0040] The preparation method of the pharmaceutical composition for treating hypertension:

[0041] a. Add water to decoct plantain head, white uncaria, Fujian cypress, and shepherd's chestnut for 2 times, add 7 volumes of water for the first time, decoct for 1.5 hours, add 5 times the volume of medicine for the second time, decoct for 1 hour hours, combine the decoction and set aside;

[0042] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0043] c. mixing the indapamide with t...

Embodiment 2

[0047] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0048] Indapamide 2.0g, plantain head 3500g, white uncaria 2500g, fukien cypress 3500g, shepherd's head 2500g.

[0049] The preparation method of the pharmaceutical composition for treating hypertension:

[0050] a. Add water to decoct plantain head, white uncaria, Fujian cypress, and shepherd's chestnut for 2 times, add 8 volumes of water for the first time, decoct for 2 hours, add 6 times the volume of medicine for the second time, decoct for 1.5 hours, combine the decoction and set aside;

[0051] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0052] c. mixing the indapamide with the d...

Embodiment 3

[0056] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0057] Indapamide 3.0g, plantain head 2500g, white uncaria 3500g, fukien cypress 2500g, shepherd's head 3500g.

[0058] The preparation method of the pharmaceutical composition for treating hypertension:

[0059] a. Add water to decoct plantain head, white uncaria, Fujian cypress, and shepherd's chestnut for 2 times, add 6 volumes of water for the first time, decoct for 1 hour, add 4 times the volume of medicine for the second time, decoct 0.5 hours, combine the decoction and set aside;

[0060] b. Concentrate the decoction liquid at 65°C and -0.04Mpa into a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0061] c. mixing the indapamide with the dry po...

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PUM

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Abstract

The invention belongs to the technical field of medicine and particularly relates to an indapamide-containing medicine composition for treating hypertension and a preparation method thereof.The indapamide-containing medicine composition for treating hypertension is prepared from, by weight, 1.5-3.5 parts of indapamide, 2,000-4,000 parts of musa basjoo sieb et zucc., 2,000-4,000 parts of uncaria sessilifructus, 2,000-4,000 parts of fokienia hodginsii and 2,000-4,000 parts of herb of largeserrate mosla.The traditional Chinese medicine and indapamide are combined, the common gastrointestinal tract adverse reactions to indapamide can be avoided, and the treatment effect on hypertension can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing indapamide for treating hypertension and a preparation method thereof. Background technique [0002] Hypertension is an important etiology and risk factor of cardiovascular and cerebrovascular diseases, and 20%-30% of people worldwide suffer from hypertension. High blood pressure can affect the structure and function of the heart, brain, and kidney, and significantly increase the risk of stroke, heart failure, and end-stage renal disease. Essential hypertension accounts for 95% of the incidence of hypertension. The survey in 2002 showed that the prevalence rate of people over the age of 18 in my country was as high as 18.8%, and the number of patients reached 160 million. Therefore, the prevention and treatment of hypertension has become a major public health issue that is of the greatest concern in my country and the world. ...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P9/12A61K31/404
CPCA61K31/404A61K36/14A61K36/53A61K36/74A61K36/88A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 张晓伟
Owner JINAN BANGWEN MEDICAL TECH
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