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Application of rare earth alendronate in preparation of osteoporosis treatment drug

A technology for alendronate and osteoporosis, applied in the field of medicine, can solve the problems of increased risk of endometrial cancer and ovarian cancer, inability to be widely used, expensive and other problems, so as to reduce bone risk, reduce and The effect of avoiding the risk of fracture and improving the fracture strength of the bone

Inactive Publication Date: 2016-07-27
HAINAN NORMAL UNIV
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Problems solved by technology

[0003] The current anti-osteoporosis drugs are unsatisfactory. Estrogen replacement therapy (ERT) is currently the most important method for the prevention and treatment of postmenopausal osteoporosis, but recent studies have shown that ERT is prone to breast cancer, uterine Increased risk of endometrial and ovarian cancer
In addition, the most common osteoporosis drugs used clinically are mostly expensive and cannot be widely used, so finding other drugs to prevent and treat osteoporosis is an active field of current research work

Method used

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  • Application of rare earth alendronate in preparation of osteoporosis treatment drug

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Experimental program
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Embodiment Construction

[0013] 1. In vitro test

[0014] Rare earth alendronate (lanthanum alendronate, cerium alendronate, praseodymium alendronate, neodymium alendronate, promethium alendronate, samarium alendronate, europium alendronate, Gadolinium alendronate) was prepared into 10 mg / mL stock solution with PBS (phosphate buffered saline), and diluted to 1000 μg / mL and 100 μg / mL before use.

[0015] Experimental procedure: Take the primary cultured rat osteoblasts (OB) in 2×10 4 cells / mL were inoculated in a 96-well plate with a volume of 90 μL per well in CO 2 Cultivate in the incubator for 24h. After the cells adhere to the wall, add 10 μL of PBS solution of rare earth alendronate, so that the final concentration of rare earth alendronate is 100 μg / mL, 10 μg / mL, after culturing for 48 hours, add MTT solution (5 mg / mL ) 10 μL, continue to incubate in the incubator for 4 h, pour off the supernatant, add 100 μL of DMSO to each well, measure the absorbance value of each well at 570 nm with a micr...

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Abstract

The invention discloses an application of rare earth alendronate in preparation of an osteoporosis treatment drug. The rare earth alendronate comprises one or more of alendronate lanthanum, alendronate cerium, alendronate praseodymium, alendronate neodymium, alendronate promethium, alendronate samarium, alendronate europium and alendronate gadolinium. The osteoporosis treatment drug prepared from rare earth alendronate has obvious therapeutic action on reduction of osteoblast viability and reduction of bone biochemical strength of a model rat with osteoporosis and does not have obvious toxic and side effects.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of rare earth alendronate in the preparation of medicines for treating osteoporosis. Background technique [0002] Osteoporosis (OP) is a systemic skeletal disease characterized by decreased bone mass and degeneration of bone microstructure, resulting in increased bone fragility and susceptibility to fracture. Osteoporosis is a global health problem, second only to cardiovascular disease in severity, and its incidence rate has jumped to the sixth place among common diseases and frequently-occurring diseases in the world. my country lists osteoporosis as one of the geriatric diseases that the country focuses on. [0003] The current anti-osteoporosis drugs are unsatisfactory. Estrogen replacement therapy (ERT) is currently the most important method for the prevention and treatment of postmenopausal osteoporosis, but recent studies have shown that ERT is prone t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K31/662A61P19/10
CPCA61K31/662A61K33/24A61K2300/00
Inventor 戴春燕朱林华陈光英孙丽丽
Owner HAINAN NORMAL UNIV
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