Calcium citrate salt and preparation method and application thereof

A technology of calcium citrate salt and application, applied in the directions of carboxylate preparation, food preparation, cyanide reaction preparation, etc., can solve the technical enlightenment and single problem of not giving a variety of alkyl L-carnitine salts , to achieve strong and more functional nutrition and therapeutic effects, suitable for oral administration, easy storage and transportation

Active Publication Date: 2016-07-20
リャオニンコンセプヌトラシーオーエルティーディー
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The L-carnitine calcium citrate prepared by the publication number CN102911069A is a salt of calcium citrate and L-carnitine. It is only a single calcium citrate salt. The technical inspiration of the salt formation of base L-carnitine, such as the salt formation of L-arginine, L-lysine, acetyl L-carnitine, propionyl L-carnitine, etc.

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  • Calcium citrate salt and preparation method and application thereof
  • Calcium citrate salt and preparation method and application thereof
  • Calcium citrate salt and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Preparation of L-arginine calcium citrate salt.

[0039]

[0040] Dissolve 21 grams (0.1 mol) of citric acid monohydrate in 200 ml of water, add 7.4 grams (0.1 mol) of calcium hydroxide, dissolve at room temperature, filter the solution after it is transparent, and remove SiO in calcium hydroxide 2 Wait for impurities, add 17.4 grams (0.1mol) of L-arginine to the clean filtrate, stir and react at 70-80°C for 4 hours, then concentrate, add absolute ethanol to crystallize after cooling down, filter and dry, and the obtained L-arginine Amino acid citrate calcium salt 38.8 grams, has good fluidity and anti-hygroscopicity, yield 96.0%.

[0041] [α] D 20 =+10.8° (C=1,0.5NHCl), L-arginine HPLC content 42.4%, citric acid HPLC content 47.0%, calcium content 9.7%.

Embodiment 2

[0042] Embodiment 2: Preparation of calcium salt of L-lysine citrate.

[0043]

[0044] Dissolve 21 grams (0.1mol) of citric acid monohydrate in 200ml water, add 5.6 grams (0.1mol) of calcium oxide, dissolve at room temperature, filter the solution after it is transparent, and remove SiO in calcium oxide 2 Wait for impurities, add 14.6 grams (0.1mol) of L-lysine to the clean filtrate, stir and react at 70-80°C for 4 hours, then concentrate, add absolute ethanol to crystallize after cooling down, filter and dry, and the obtained L-lysine Amino acid citrate calcium salt 36.5 grams, has good fluidity and anti-hygroscopicity, yield 97.1%.

[0045] [α] D 20 =+8.8°(C=1,0.5NHCl), L-lysine HPLC content 39.4%, citric acid HPLC content 50.2%, calcium content 10.0%.

Embodiment 3

[0046] Example 3: Preparation of acetyl L-carnitine citrate calcium salt.

[0047]

[0048] Dissolve 21 grams (0.1mol) of citric acid monohydrate in 200ml of water, add 10.0 grams (0.1mol) of calcium carbonate, dissolve at room temperature, filter the solution after it is transparent, and remove SiO in calcium carbonate 2 Wait for impurities, add 20.3 g (0.1 mol) of acetyl L-carnitine to the clean filtrate, stir and react at 70-80°C for 4 hours, then concentrate, add absolute ethanol to crystallize after cooling down, filter and dry, the obtained acetyl L-carnitine 41.5 grams of carnitine citrate calcium salt has good fluidity and moisture absorption resistance, and the yield is 95.8%.

[0049] [α] D 20 =-12.2° (C=1,0.5NHCl), acetyl L-carnitine HPLC content 45.9%, citric acid HPLC content 45.2%, calcium content 8.5%.

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Abstract

A calcium citrate salt and its preparation method and application are disclosed. The calcium citrate salt has stronger nutritional and therapeutical effects than simple calcium citrate. The preparation method comprises the following steps: dissolving citric acid in water, adding calcium oxide or calcium hydrate or calcium carbonate, filtering to remove foreign materials after the solution is dissolved to be transparent, adding L-arginine or L-lysine or acetyl L-carnitine or propionyl l-carnitine into a filtrate, reacting at 0-100 DEG C for 2-8 h, carrying out vacuum concentration, cooling, carrying out crystallization by adding anhydrous ethanol, filtering and drying, and detecting to be qualified so as to obtain the product. A composition containing the calcium citrate salt can be made into one or more pharmacologically acceptable excipients, especially a solid-liquid oral preparation, such as pulvis, a particulate agent, a tablet, capsules and an oral liquid, etc., or directly made into a beverage, and can be used as dietary / nutritional supplement for human or a feed supplement for animals, including nutritional supplements for supplementing L-arginine, L-lysine, acetyl L-carnitine and propionyl L-carnitine.

Description

technical field [0001] The present invention relates to a stable, non-hygroscopic, acceptable salt for supplementing nutrients, in particular to a calcium citrate salt and its preparation method and use, which belongs to the preparation technology of food additives and is suitable for the preparation of human or Veterinary food additives and nutritional supplements, including L-arginine, L-lysine, acetyl L-carnitine, and propionyl L-carnitine nutritional supplement composition. Background technique [0002] Natural citric acid is widely distributed in nature. Natural citric acid exists in the bones, muscles and blood of plants such as lemons, citrus, pineapples and other fruits and animals. Synthetic citric acid is obtained by fermenting sugar, molasses, starch, grapes and other sugar-containing substances, and can be divided into anhydrous and hydrate. Pure citric acid is colorless transparent crystal or white powder, odorless, with an attractive sour taste. Many fruits a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/265C07C51/41C07C279/14C07C277/08C07C229/26C07C227/18C07C229/22A61K31/205A61K31/198A61K31/194A61P3/02A23L1/30A23K1/16
Inventor 卿笃清庄昊袁学亮张炳辉关秋梅国庆于时龙
Owner リャオニンコンセプヌトラシーオーエルティーディー
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