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Traditional Chinese medicinal composition for treating uveitis and preparation method thereof

A technology for uveitis and a composition is applied in the field of traditional Chinese medicine compositions and preparations for the treatment of uveitis, and the fields of traditional Chinese medicine compositions and preparations thereof, to achieve the effects of excellent therapeutic effect and good clinical application potential.

Pending Publication Date: 2016-07-20
毕宏生 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] As mentioned above, although a variety of traditional Chinese medicine compositions that can be used to treat uveitis are disclosed in the prior art, there are still some defects, such as simple mixing of original Chinese herbal medicines, or simple extraction of active ingredients

Method used

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  • Traditional Chinese medicinal composition for treating uveitis and preparation method thereof
  • Traditional Chinese medicinal composition for treating uveitis and preparation method thereof
  • Traditional Chinese medicinal composition for treating uveitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0078] Preparation Example 1: Preparation of Myrobalan Extract

[0079] A1: Pulverize Myrobalan, pass through a 100-mesh sieve, and obtain Myrobalan powder;

[0080] A2: Add the myrobalan powder to 3 times the weight of an aqueous hydrochloric acid solution with a concentration of 5% by mass, raise the temperature to 55° C., soak for 9 hours, filter, and fully dry the obtained powder to obtain a treated powder;

[0081] A3: The processing powder is added in the Soxhlet extractor, and the ethanol that is 50% is extracted with the mass percent concentration (the mass ratio of the described processing powder and the mass percent concentration is 50% ethanol is 1:12), with two Toluene is used as a water-carrying agent (the volume ratio of xylene and mass percent concentration of 50% ethanol is 1:15), reflux extraction for 70 minutes, then filter, and the filtrate is distilled under reduced pressure to obtain a viscous substance;

[0082] A4: Dissolve the viscous substance with an...

preparation example 2

[0090] Preparation Example 2: Preparation of Semen Cassiae Extract

[0091] B1: Crush cassia seeds to obtain a powder, add it to an aqueous ethanol solution with a concentration of 40% by mass, fully soak overnight, filter out the powder, and fully dry to obtain a powder to be treated;

[0092] B2: Extract the powder to be treated with 15 times the mass of n-hexane under reflux for 70 minutes, and filter to obtain the extract;

[0093] B3: Concentrate the extract under reduced pressure, dissolve the residue with an appropriate amount of ether, and apply 300-400 mesh silica gel column chromatography (the mass ratio of the residue to the silica gel in the silica gel column chromatography is 1:75), successively use acetone, mass Percentage concentration is 50% ethanol aqueous solution and chloroform to carry out eluting (the mass ratio of acetone, mass percentage concentration is 50% ethanol aqueous solution and chloroform and described residue is respectively 15:1, 10:1 and 30:1...

preparation example 3

[0096] Preparation Example 3: Preparation of Dendrobium Extract

[0097] C1: Dendrobium is 10% Na with mass percentage concentration 2 CO 3 Soak in aqueous solution for 15 hours, then wash with deionized water for 2-3 times, after completely drying, pulverize and pass through a 100-mesh sieve to obtain dendrobium powder;

[0098] C2: fully mix n-propanol, polyethylene glycol 200 and deionized water with a volume ratio of 2:1:1 to obtain a composite extract, and add the dendrobium powder to the composite extract (the dendrobium powder and The mass ratio of the composite extract is 1:20), warming up to 85°C, stirring and extracting at this temperature for 90 minutes, and filtering to obtain the filtrate;

[0099] C3: Add 2 times the volume of ethyl acetate to the filtrate, fully oscillate for extraction, stand and separate layers, separate the ethyl acetate phase, concentrate under reduced pressure, crush the obtained paste and pass through a 100-mesh sieve to obtain The dend...

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Abstract

The invention relates to a traditional Chinese medicinal composition for treating uveitis and a preparation method thereof. The traditional Chinese medicinal composition is prepared from a fructus chebulae extract, a semen cassiae extract, a herba dendrobii extract, an elephantopus herb extract, flos cartham, herba adhatoda vacica nees, radix aucklandiae, benzoin and artificial moschus. The traditional Chinese medicinal composition has a favorable effect for treating the uveitis, so that the traditional Chinese medicinal composition for treating the uveitis can be applied to the field of ophthalmological treatment, and has an excellent treatment effect and an application prospect in clinical treatment.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, more specifically to a traditional Chinese medicine composition for treating uveitis and a preparation method thereof, belonging to the technical field of traditional Chinese medicine application. Background technique [0002] In ophthalmic diseases, uveitis is a very common eye disease. It usually manifests as inflammation of the iris, ciliary body, and choroid. If the choroid is also inflamed, it is called uveitis. The more popular classifications are anterior uveitis, posterior uveitis, and panuveitis. [0003] Uveitis often occurs in young and middle-aged people. The etiology is quite complicated. Improper treatment can lead to blindness. It accounts for an important proportion of blinding eye diseases and has attracted worldwide attention. However, because its pathogenesis and recurrence mechanism is not completely clear, so its prevention is im...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61K9/14A61P27/02A61K35/55
CPCA61K36/185A61K9/14A61K35/55A61K36/28A61K36/285A61K36/286A61K36/482A61K36/68A61K36/8984A61K2236/33A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 毕宏生高西鹏郭俊国井伟王兴荣辛加山解孝锋宋继科
Owner 毕宏生
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