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Vitamin D and calcium-containing microemulsion as well as preparation method and application thereof

A vitamin and microemulsion technology, which is used in food ingredients containing vitamins, medical preparations containing active ingredients, applications, etc., can solve the problems of unstable emulsion and easy oxidation of vitamin D, and achieve uniform particle dispersion, good stability, Simple preparation method

Inactive Publication Date: 2016-07-20
李宏 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the emulsion containing vitamin D and calcium disclosed in the prior art usually has the problem that vitamin D is easily oxidized and the emulsion is unstable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 (the embodiment with the best effect)

[0027] This embodiment provides a microemulsion containing vitamin D calcium, which is prepared from the following components by weight: vitamin D 3 0.0013%, calcium lactate 5.7%, emulsifier 1.2%, soybean oil 5%; wherein the emulsifier is obtained by mixing soybean lecithin and citric acid fatty acid glyceride in a mass ratio of 1:1.

[0028] The obtained microemulsion had a pH value of 7.5.

[0029] The microemulsion containing vitamin D calcium described in the present embodiment is made by following method:

[0030] (1) Take the prescribed amount of purified water, adjust the pH value to 11, add calcium lactate and an emulsifier, under the protection of nitrogen, cut the emulsifier until it is evenly dispersed, and control the water temperature at 60°C to obtain the water phase;

[0031] (2) adding vitamin D into soybean oil, heating to 50°C to obtain an oil phase;

[0032] (3) Add the oil phase to the water pha...

Embodiment 2

[0036] This example provides a vitamin D calcium-containing microemulsion, which is different from Example 1 in that the emulsifier is obtained by mixing soybean lecithin and citric acid fatty acid glyceride at a mass ratio of 3:1.

Embodiment 3

[0038] This example provides a microemulsion containing calcium vitamin D, which is different from Example 1 in that the microemulsion system is 6.5.

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Abstract

The invention relates to a vitamin D and calcium-containing microemulsion as well as a preparation method and an application thereof. The microemulsion comprises the following components in percentage by weight: 0.0005-0.5% of vitamin D, 1.0-10.0% of calcium source, 0.5-3% of emulsifier and 1.0-10.0% of vegetable oil. The microemulsion is less in emulsifier dosage, simple in preparation method, high in drug-loading rate, uniform in particle dispersion and good in stability and has the advantages that the particle size reaches nanometer scale; the vitamin D can be well protected from the influence of environmental factors and oxidation products harmful to the human health cannot be produced; and the bioavailability is increased at the same time.

Description

technical field [0001] The invention relates to a vitamin D calcium-containing microemulsion and a preparation method and application thereof, belonging to the field of food health product preparation. Background technique [0002] Calcium is the basic raw material for bone development. In addition to directly affecting height, it also plays an important role in maintaining the health of the body and ensuring normal growth and development. Such as participating in the activities of nerves and muscles and the release of neurotransmitters; regulating the secretion of hormones. Regulate heart rhythm, reduce cardiovascular permeability, control inflammation and edema, maintain acid-base balance, etc. [0003] Vitamin D is a sterol derivative with anti-rickets effect, also known as anti-rickets vitamin. At present, it is considered that vitamin D is also a steroid hormone, and the most important members of the vitamin D family are VD2 (ergocalciferol) and VD3 (cholecalciferol)....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/155A23L33/16A23L29/10A61K9/107A61K31/593A61P3/02A61K31/19
CPCA23V2002/00A61K9/1075A61K31/19A61K31/593A23V2200/30A23V2250/1578A23V2250/71A61K2300/00
Inventor 高山李宏郑攀刘楠范玲玲李平陈静芳
Owner 李宏
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