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Drug composition of citicoline sodium and medical application of drug composition

A technology of citicoline sodium and its composition, which is applied in the field of citicoline sodium pharmaceutical composition, can solve the problems that have not been reported related to citicoline sodium and its pharmaceutical composition, and achieve anti-tumor effect Improved effect

Inactive Publication Date: 2016-07-13
吴国春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between citicoline sodium and its pharmaceutical composition and anti-tumor

Method used

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  • Drug composition of citicoline sodium and medical application of drug composition
  • Drug composition of citicoline sodium and medical application of drug composition
  • Drug composition of citicoline sodium and medical application of drug composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0021] Separation method: (a) Pulverize Tianzhuhuang (2kg), extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and successively use petroleum ether (3L×3 times) ), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a ) in ethyl acetate extract with D101 type macroporous resin to remove impurities, first elute 12 column volumes with 20% ethanol, then elute 15 column volumes with 80% ethanol, collect 80% eluate, and concentrate under reduced pressure Obtain 80% ethanol elution concentrate; (c) in step (b), 80% ethanol elution concentrate is separated with normal phase silica gel, is 80:1 (10 column volumes), 40:1 (8 column volume), 20:1 (8 column volumes) and 10:1 (9 column volumes) dichlorom...

Embodiment 2

[0025] Embodiment 2: pharmacological action

[0026] 1. Materials and methods

[0027] 1.1 Animals

[0028] Healthy ICR mice, clean grade, weighing 18-22 g, half male and half male, were provided by the Provincial Key Laboratory of Natural Drug Pharmacology, Kunming Medical College. The animals were kept in a ventilated and dry environment with a temperature of (22±1)°C, a relative humidity of 55%-65%, and a 12-h light cycle, and were fed with maintenance diet 1022 for rats and mice.

[0029] 1.2 Reagents and samples

[0030] Citicoline sodium was purchased from China National Institutes for Food and Drug Control. Compound (I) is self-made, and the preparation method is shown in Example 1. Cisplatin (DDP) was purchased from Yunnan Gejiu Biopharmaceutical Co., Ltd.

[0031] 1.3 Mouse grouping and model preparation

[0032] Take well-growing tumor cells and adjust to a certain concentration with normal saline (S180: 6×10 6 / mL; H22: 5×10 6 / mL). Each mouse was subcutane...

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Abstract

The invention discloses a drug composition of citicoline sodium and medical application of the drug composition.The drug composition of the citicoline sodium comprises the citicoline sodium and a natural product chemical compound (I) of a novel structure, and the citicoline sodium and the chemical compound (I) have an inhibiting effect on transplanted tumor when acting independently; the citicoline sodium and the chemical compound (I) have a more remarkable inhibiting effect on transplanted tumor when acting jointly, the safety is high, the toxicity is low, the drug for inhibiting tumor can be developed, and compared with the prior art, the drug composition has prominent substantive features and remarkable advancement.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of citicoline sodium, in particular to a pharmaceutical composition of citicoline sodium and its medical application. Background technique [0002] Citicoline sodium can promote brain substance metabolism and improve cerebral circulation by reducing cerebrovascular resistance and increasing cerebral blood flow. It can also enhance the function of the ascending reticular activation system of the brain stem, enhance the function of the vertebral system, and improve motor paralysis, so it has a certain effect on promoting the recovery of brain function and waking up. It is mainly used clinically for disturbance of consciousness after acute craniocerebral trauma and brain surgery. [0003] So far, there is no report on the correlation between citicoline sodium and its pharmaceutical composition and anti-tumor. Contents of the invention [0004] The object of the present ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/733C07C45/79A61K31/7068A61K31/122A61P35/00
CPCC07C49/733A61K31/122A61K31/7068A61K36/899C07C45/79
Inventor 吴国春
Owner 吴国春
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