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Immobilized metal porphyrin enzyme catalyst and preparation method thereof

A technology for immobilizing metals and metalloporphyrins, applied in physical/chemical process catalysts, chemical instruments and methods, organic compounds/hydrides/coordination complex catalysts, etc. And strong corrosiveness and other problems, to achieve mild conditions, promote rapid transformation, and strong specificity

Inactive Publication Date: 2016-07-13
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since FDCA can be obtained by selective oxidation of hydroxymethylfurfural (HMF), and the direct oxidation of HMF oxidant is likely to produce a large number of by-products and is highly corrosive, it is difficult to become a green production process for FDCA, so the development of green and efficient catalysts has become particularly important.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 This embodiment illustrates the catalyst method of synthetic metalloporphyrinase

[0033] Pyridyl porphyrin compound in CoCl 2 solution with FeCl 2 Coordination reaction to form metalloporphyrinase;

[0034] The ionic liquid with the anion functional group of hydroxyl and the cationic functional group of amino is reacted with mesoporous activated carbon molecular sieve material in toluene solution at 110° C. for 24 hours; the carrier is obtained by filtration. Then use dichloromethane Soxhlet extraction for 20h to filter to obtain the carrier, then put the metalloporphyrinase solution into 0.0125M Tris-HCl buffer solution (50mL, pH7.0), and introduce the surface-modified mesoporous activated carbon molecular sieve material. The mixed solution was stirred at a temperature of 30 °C and a rotation speed of 150 rpm until the sample reached adsorption equilibrium.

Embodiment 2

[0035] Example 2 This example illustrates embedding

[0036] Immerse the immobilized metalloporphyrinase solution in CaCl 2solution and stirred for 1 h, the mixture was injected into 2% w / v sodium alginate solution for aging, and finally the enzyme was encapsulated by calcium alginate gel to obtain immobilized metalloporphyrinase embedded in calcium alginate gel , and then dried for later use.

Embodiment 3

[0037] Example 3 This example illustrates the use of immobilized metalloporphyrinase catalysts to catalyze the oxidation of hydroxymethylfurfural (HMF) to furandicarboxylic acid (FDCA)

[0038] Take 1.0g of hydroxymethylfurfural and 5mL of acetonitrile solution into a 10mL round bottom flask, and stir the solution until the solution is clear, then add 50mg of immobilized metalloporphyrinase catalyst and 70% of TBHP oxidant, and generate at 110°C After 60 hours of reaction, the oxidant and catalyst are recovered for future use. Finally, the reaction conversion rate and product purity were analyzed by VarianProstar high performance liquid chromatography.

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PUM

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Abstract

The invention provides an immobilized metal porphyrin enzyme catalyst and a preparation method thereof. The catalyst can oxidatively catalyze hydroxymethyl furfural (HMF) to generate a furandicarboxylic acid (FDCA) on presence of a selective oxidant.

Description

technical field [0001] The invention belongs to the technical field of biocatalysis, relates to an immobilized metalloporphyrinase catalyst and a preparation method thereof, and also relates to a method for generating 2,5-furandicarboxylic acid (FDCA) from hydroxymethylfurfural (HMF) by using the enzyme to oxidize and catalyze hydroxymethylfurfural (HMF). Background technique [0002] First of all, with the advancement of petrochemical technology, the development of polymer materials using petrochemical derivatives as raw materials has been promoted. However, due to the inability to degrade such polymer materials, the environmental problems caused by them have gradually attracted the attention of the public. A global "white revolution". In order to alleviate the dependence on fossil resources and the impact of polymer materials on the environment, the development of biomass resources has become a hot research topic in various countries in recent years. 2,5-furandicarboxylic...

Claims

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Application Information

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IPC IPC(8): B01J31/22B01J31/16C07D307/68
CPCB01J31/1616B01J31/003B01J31/183B01J2231/70B01J2531/025B01J2531/16B01J2531/26B01J2531/42B01J2531/72B01J2531/842B01J2531/845C07D307/68
Inventor 邹彬陈学珊夏姣姣霍书豪邓甜崔凤杰
Owner JIANGSU UNIV
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