Cystatin C latex-particle-enhanced turbidimetry detection reagent kit and application thereof
A detection kit and latex-enhanced technology, which is applied in the field of immunological determination and analysis, can solve problems such as weak linear correlation and poor precision, and achieve the effects of shortening detection time, high sensitivity, and improving detection sensitivity
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Embodiment 1
[0075] The components and concentration ranges of the reagent R1 are:
[0076]
[0077] The components and concentration ranges of the reagent R2 are:
[0078]
[0079]
[0080] Reagent R1 is a colorless and transparent solution, reagent R2 is a uniform milky white solution, and the reference calibrator of Cystatin C reagent is also a colorless and transparent solution.
Embodiment 2
[0082] The components and concentration ranges of the reagent R1 are:
[0083]
[0084] The components and concentration ranges of the reagent R2 are:
[0085]
[0086] Reagent R1 is a colorless and transparent solution, R2 is a uniform milky white solution, and the reference calibrator of Cystatin C reagent is also a colorless and transparent solution.
[0087] Comparative example 1R1 reagent composition is identical with embodiment 1, and R2 reagent composition and embodiment 1 are except that latex diameter is different, and all the other compositions are identical, and R2 latex diameter is respectively: described large-diameter polystyrene latex particle average particle diameter is 400nm~ 600nm, the average particle diameter of the small-diameter polystyrene latex is 16nm~32nm, large-diameter polystyrene latex particles: small-diameter polystyrene latex particles=(7-10):(0-3).
[0088] Comparative example 2R1 reagent composition is identical with embodiment 2, and ...
Embodiment 1 and 2
[0107] table 3
[0108]
[0109]
[0110] 4. Comparison of the anti-interference performance of the two kits:
[0111] Add four kinds of interfering substances to form mixed serum in the Roche quality control product (marked value 8.2mg / l), and the measurement results are as follows: total bilirubin assay kit of the present invention and existing kit measure anti-interference performance comparison:
[0112] Table 4
[0113]
[0114] The above-mentioned technical solutions in the embodiments of the present application have at least the following technical effects or advantages:
[0115] (1), the kit of the present invention uses latex-enhanced immunoturbidimetry to measure cystatin C, which amplifies the detection signal, improves the detection sensitivity, and shortens the detection time.
[0116] (2), the present invention adopts the latex reagent of mixed particle size, wherein the latex particle ratio of small particle size is big, has improved linearity; Contai...
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