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Haem oxygenase drug eluting stent

A technology of heme oxygenase and eluting stents, which is applied in the field of heme oxygenase drug-eluting stents, can solve the problems of delayed stent surface endothelialization, and achieve the prevention of thrombosis in stents, inhibition of inflammatory reactions, and inhibition of foreign matter The effect of rejection

Inactive Publication Date: 2016-07-06
诺莱生物医学研究院(北京)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to solve the problem that the existing drug stent inhibits the proliferation of vascular endothelial cells and delays the endothelialization of the stent surface

Method used

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  • Haem oxygenase drug eluting stent
  • Haem oxygenase drug eluting stent
  • Haem oxygenase drug eluting stent

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Embodiment Construction

[0019] Hereinafter, the present invention will be further described in conjunction with the embodiments and drawings. It should be understood that the embodiments are only for illustration and not intended to limit the protection scope of the present invention.

[0020] The eluting stent in this embodiment is a drug-eluting stent with heme oxygenase adsorbed on the bare stent. The coating concentration of heme oxygenase in the heme oxygenase coating is 1umol / mm 2 .

[0021] The "coating concentration" referred to in the present invention means: the amount of heme oxygenase contained in each square millimeter area of ​​the surface of the stent.

[0022] The heme oxygenase used in this embodiment can be prepared by the following synthetic method:

[0023] The human heme oxygenase gene is transfected into the eukaryotic expression vector Pichia pastoris, the protein is synthesized in Pichia pastoris, and then the target protein is purified and concentrated. The synthesized HO ...

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Abstract

The invention relates to a haem oxygenase drug eluting stent. The haem oxygenase drug eluting stent comprises a stent body, and haem oxygenase is adsorbed to the surface of the stent body. According to the haem oxygenase drug eluting stent, HO is adsorbed to the surface of an intravascular stent, After the stent is placed in an embolism blood vessel, enzymolysis and lesion are conducted on abundant heme at the blood vessel, CO is generated, CO can be freely diffused to adjacent vascular endothelial cells and smooth muscles to generate a biological effect, proliferation of smooth muscle cells can be inhibited, restoration of the endothelial cells can be promoted, meanwhile, the effects of inhibiting the inflammatory reaction, inhibiting the foreign matter rejection reaction and resisting to platelet aggregation are achieved, the efficacy of preventing post-stenting restenosis and stent throbosis formation is achieved, and the haem oxygenase is an ideal stent coating drug integrating multiple functions.

Description

[technical field] [0001] The invention relates to a stent for blood vessels, in particular to a heme oxygenase drug-eluting stent. [Background technique] [0002] Coronary atherosclerotic heart disease, referred to as coronary heart disease (CHD), refers to heart disease caused by myocardial ischemia and hypoxia due to narrowing or obstruction of the lumen due to coronary atherosclerosis. Coronary heart disease is currently the leading cause of death in developed countries. CHD is projected to be the leading cause of death in the world by 2020. Over the past half century, significant progress has been made in the medical and surgical treatment of coronary heart disease, especially the emergence of interventional technology, which has brought good news to the treatment of coronary heart disease. [0003] Interventional treatment of coronary heart disease has a history of 32 years. The world's first case of percutaneous transluminal coronary angioplasty (PTCA for short) was ...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/16A61L33/16
CPCA61L31/16A61L31/10A61L33/0047A61L33/128A61L2300/412A61L2300/42C08L89/00
Inventor 顾宇春
Owner 诺莱生物医学研究院(北京)有限公司
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