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Medicine composition for treating hypertension containing propranolol and preparation method of medicine composition

A composition and technology for hypertension, applied in the field of medicine, can solve problems such as restricting the use of propranolol, slow response, etc., and achieve the effects of avoiding adverse reactions, small side effects, and lowering blood pressure

Inactive Publication Date: 2016-06-29
JINAN BANGWEN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Common adverse reactions of propranolol are central nervous system adverse reactions, such as dizziness, confusion (especially in the elderly), mental depression, unresponsiveness, and the incidence rate is as high as 25%. This adverse reaction limits the clinical application of propranolol. usage of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0039] 10g of propranolol, 3000g of Ganmutong, 3000g of plantain peel, 3000g of snow tea, 3000g of wild tea.

[0040] The preparation method of the pharmaceutical composition for treating hypertension:

[0041] a. Decoct Ganmotong, plantain peel, snow tea, and wild tea seed with water for 2 times, add 7 volumes of water for the first time, decoct for 1.5 hours, add water 5 times the volume of the medicine for the second time, and decoct 1 hour, combine the decoction liquid and set aside;

[0042]b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0043] c. Propranolol is mixed with dry powder,...

Embodiment 2

[0047] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0048] 7.5g of propranolol, 3500g of ganmotong, 2500g of plantain peel, 3500g of snow tea, and 2500g of wild tea.

[0049] The preparation method of the pharmaceutical composition for treating hypertension:

[0050] a. Add water to decoct Ganmotong, plantain peel, snow tea, and wild tea seeds twice, add 8 volumes of water for the first time, decoct for 2 hours, add water 6 times the volume of the medicine for the second time, and decoct After 1.5 hours, combine the decoction and set aside;

[0051] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0052] c. Propranolol is mixed with dry powd...

Embodiment 3

[0056] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0057] 12.5g of propranolol, 2500g of Ganmutong, 3500g of plantain peel, 2500g of snow tea, 3500g of wild tea.

[0058] The preparation method of the pharmaceutical composition for treating hypertension:

[0059] a. Add water to decoct ganmotong, plantain peel, snow tea, and wild tea seeds twice, add 6 volumes of water for the first time, decoct for 1 hour, add water 4 times the volume of the medicine for the second time, and decoct After 0.5 hours, combine the decoction and set aside;

[0060] b. Concentrate the decoction liquid at 65°C and -0.04Mpa into a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0061] c. Propranolol is mixed with dry powder, ...

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Abstract

The invention belongs to the technical field of medicines, and in particular relates to a medicinal composition containing propranolol for treating hypertension and a preparation method thereof. The pharmaceutical composition for the treatment of hypertension containing propranolol of the present invention is made up of the raw material drug of the following proportioning by weight: 5-15 parts of propranolol, 2000-4000 parts of Ganmutong, 2000-4000 parts of plantain peel 2000‑4000 parts of snow tea, 2000‑4000 parts of wild tea. The invention combines traditional Chinese medicine with propranolol, can avoid the common adverse reactions of propranolol, and improve the therapeutic effect on hypertension.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a medicinal composition containing propranolol for treating hypertension and a preparation method thereof. Background technique [0002] Hypertension is an important etiology and risk factor of cardiovascular and cerebrovascular diseases, and 20%-30% of people worldwide suffer from hypertension. High blood pressure can affect the structure and function of the heart, brain, and kidney, and significantly increase the risk of stroke, heart failure, and end-stage renal disease. Essential hypertension accounts for 95% of the incidence of hypertension. The survey in 2002 showed that the prevalence rate of people over the age of 18 in my country was as high as 18.8%, and the number of patients reached 160 million. Therefore, the prevention and treatment of hypertension has become a major public health issue that is of the greatest concern in my country and the world. [...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P9/12A61K31/138
CPCA61K31/138A61K9/1652A61K36/09A61K36/716A61K36/82A61K36/88A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 不公告发明人
Owner JINAN BANGWEN MEDICAL TECH
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