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Preparation method of carnosol and chitosan composite nanometer fiber mat

A technology of composite nanofibers and carnosol, applied in the direction of fiber treatment, fiber chemical characteristics, spinning solution preparation, etc., to achieve the effect of excellent antibacterial effect, easy industrialization and low price

Inactive Publication Date: 2016-06-22
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the above reasons, the preparation of new carnosol composite nanofiber mat is of great significance, and the current research literature and patent related content are very few

Method used

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  • Preparation method of carnosol and chitosan composite nanometer fiber mat
  • Preparation method of carnosol and chitosan composite nanometer fiber mat

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Take 2000g of dried rosemary branches and leaves, add 10L of dichloromethane, reflux extraction 3 times, each time for 3 hours, combine the extracts 3 times, concentrate and recover dichloromethane to obtain extract; dissolve the extract with 60% ethanol , remove insolubles by filtration, get 1000ml of mother liquor as adsorption solution, adsorb with 500ml AB-8 macroporous adsorption resin, elute with 1000ml purified water after completion of adsorption, then elute with 2000ml80% ethanol solution, eluent is divided into 6 section, combined 4 parts in the middle; the combined eluent was concentrated under reduced pressure to 150ml, added 200ml of water, stirred and precipitated, and left for 5 hours; centrifuged to obtain a precipitate containing carnosol; the precipitate was dissolved in 150ml of dichloromethane, and Add 200ml of petroleum ether, stir, and precipitate out; filter to obtain carnosol.

[0032] Dissolve 0.6 gram of chitosan in 15 ml of formic acid (mass v...

Embodiment 2

[0037] Take by weighing 500g of Salvia miltiorrhiza extract, dissolve with 3000ml50% ethanol, filter to remove insoluble matter, the mother liquor is adsorbed with 1000mlD101 macroporous adsorption resin, after the adsorption is completed, it is eluted with 2000ml purified water, and then eluted with 2000ml90% ethanol solution. The dehydration is divided into 6 sections, and the 4 parts in the middle are combined; the combined eluent is concentrated under reduced pressure to 500ml, added with 500ml of water, stirred and precipitated, and left for 3 hours; centrifuged to obtain a precipitate containing carnosol; precipitate with 200ml of acetic acid Dissolve the ethyl ester, add 150ml of petroleum ether therein, stir, and precipitate out; filter to obtain the active antibacterial ingredient-carnosol.

[0038] Dissolve 0.75 gram of chitosan in 15 ml of formic acid (mass volume concentration 88%), and magnetically stir until completely dissolved to obtain a chitosan solution with ...

Embodiment 3

[0043] Take 2000g of washed and dried sage, add 10L of dichloromethane, reflux extraction 3 times, each time for 3 hours, combine the extracts 3 times, concentrate and recover dichloromethane to obtain extract; extract extract with 60% ethanol Dissolve, filter to remove insoluble matter, get 1000ml mother liquor as adsorption solution, use 500ml AB-8 macroporous adsorption resin for adsorption, after the adsorption is completed, use 1000ml purified water to elute, and then use 2000ml80% ethanol solution to elute, the eluent is divided into 6 sections, combined the middle 4 parts; the combined eluate was concentrated under reduced pressure to 150ml, added 200ml of water, stirred and precipitated, and left for 5 hours; centrifuged to obtain a precipitate containing carnosol; the precipitate was dissolved in 150ml of dichloromethane, Add 200ml petroleum ether therein, stir, precipitate out; Filter to obtain active antibacterial ingredient-carnosol.

[0044] Dissolve 0.3 gram of c...

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Abstract

The invention relates to a preparation method of carnosol and chitosan composite nanofiber felt, comprising: dissolving chitosan in formic acid solution and stirring to obtain chitosan solution; mixing carnosol and chitosan The solution is mixed, stirred, and ultrasonically degassed to obtain a carnosol / chitosan solution, which is then electrostatically spun. The method of the invention is simple and easy to implement, and is easy to be industrialized, and the obtained carnosol composite nanofiber mat can be used in fields such as wound dressings, has excellent antibacterial effect, and has broad application prospects.

Description

technical field [0001] The invention belongs to the field of preparation of antibacterial polymer nanofiber materials, in particular to a preparation method of carnosol and chitosan composite nanofiber felt. Background technique [0002] There are narrow and broad definitions of nanofibers. Nanofibers in a narrow sense refer to fibers whose diameter is in the range of nanoscale, that is, defined as fibers with a diameter of 1-100 nm. Nanofibers in a broad sense mean that as long as the fibers contain nanostructures and are endowed with new physical properties, they can be classified into the category of nanofibers. Electrospinning is an important method for preparing continuous nanofibers and is expected to be industrialized. Electrospinning is to bring the polymer solution or melt to thousands to tens of thousands of volts of high-voltage static electricity, and the charged polymer droplets are accelerated at the apex of the Taylor cone of the capillary under the force of...

Claims

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Application Information

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IPC IPC(8): D04H1/4382D04H1/728D01D5/00D01D1/10D01D1/02D01F6/96D01F1/10C07D493/08
CPCD04H1/4382C07D493/08D01D1/02D01D1/103D01D5/0069D01D5/0076D01D5/0092D01F1/10D01F6/96D04H1/728
Inventor 刘保江张帅
Owner DONGHUA UNIV
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