A kind of gastrointestinal contrast agent and preparation method thereof

A technology of contrast agent and digestive tract, which is applied in the field of digestive tract contrast agent and its preparation, which can solve the problems of unfavorable imaging and achieve the effects of strong imaging ability, good biocompatibility and simple preparation process

Active Publication Date: 2019-07-05
YUNNAN KEWEI LIQUID METAL VALLEY R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pure liquid metal contrast agent has too strong metal artifacts in X-ray shooting or CT scanning, and it is not easy to hang on the wall, which is not conducive to imaging

Method used

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  • A kind of gastrointestinal contrast agent and preparation method thereof
  • A kind of gastrointestinal contrast agent and preparation method thereof
  • A kind of gastrointestinal contrast agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A gastrointestinal contrast agent comprises the following components: 1g of liquid metal gallium, 10g of barium sulfate powder (particle size 10μm), and 10g of deionized water.

[0036] The preparation method of the gastrointestinal contrast agent comprises:

[0037] 1) Put the container containing gallium into hot water at 40°C. After about 15 minutes, the gallium metal will become liquid and set aside.

[0038] 2) According to the above ratio, take liquid metal gallium and barium sulfate powder which are kept in a liquid state, mix them, and add deionized water.

[0039] 3) Stir the above mixture on a magnetic stirrer. After stirring for 24 hours, the liquid metal gallium and barium sulfate powder can be fully mixed uniformly, and the obtained mixture is the gastrointestinal contrast agent of the present invention.

Embodiment 2

[0041] A gastrointestinal contrast agent, comprising the following components: 1g of liquid metal gallium, 20g of barium sulfate powder with a particle size of 5 μm, and 20g of deionized water. The preparation method of the gastrointestinal contrast agent is similar to that of Example 1.

Embodiment 3

[0043] A gastrointestinal contrast agent comprises the following components: 10g of liquid metal gallium, 10g of barium sulfate powder with a particle size of 2 μm, and 10g of deionized water. The preparation method of the gastrointestinal contrast agent is similar to that of Example 1.

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Abstract

The invention relates to a digestive-tract contrast agent and a preparing method thereof. The digestive-tract contrast agent comprises liquid metal and barium sulfate. Compared with a traditional barium-meal contrast agent, the digestive-tract contrast agent is excellent in developing effect. In addition, the digestive-tract contrast agent can be completely discharged from the digestive tract, and the biological safety is good. The novel digestive-tract contrast agent prepared with the method is simple in preparing technology, excellent in imaging effect and good in biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of contrast agents, and in particular relates to a digestive tract contrast agent and a preparation method thereof. Background technique [0002] The digestive tract, including the esophagus, stomach, small intestine, and large intestine, requires the assistance of contrast media during examination to show the morphological and functional changes of gastrointestinal lesions under X-ray irradiation, so as to obtain detailed information on the lesion site. Among them, barium sulfate is the most commonly used gastrointestinal contrast agent in clinical practice, and the imaging effect also largely depends on the imaging ability of the contrast agent. [0003] Liquid metals represented by gallium have an X-ray absorption coefficient not lower than that of ordinary metals. Therefore, in X-ray photography or CT scanning, the tissue filled with liquid metal will form a sharp contrast with the surrounding tissue, ac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04
CPCA61K49/0404
Inventor 王倩刘欢于洋刘静
Owner YUNNAN KEWEI LIQUID METAL VALLEY R & D CO LTD
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