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Gelator and preparation method thereof as well as supramolecular metal hydrogel using gelator and preparation method and application of supramolecular metal hydrogel

A gel factor and hydrogel technology, applied in the field of supramolecular metal hydrogel and its preparation, can solve problems such as limited application and achieve the effect of good application prospects

Inactive Publication Date: 2016-06-15
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these supramolecular metallogels are organogels, which largely limits their applications.

Method used

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  • Gelator and preparation method thereof as well as supramolecular metal hydrogel using gelator and preparation method and application of supramolecular metal hydrogel
  • Gelator and preparation method thereof as well as supramolecular metal hydrogel using gelator and preparation method and application of supramolecular metal hydrogel
  • Gelator and preparation method thereof as well as supramolecular metal hydrogel using gelator and preparation method and application of supramolecular metal hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: the preparation of metal hydrogel and Co 2+ Specific recognition experiment

[0046] (1) Synthesis of gelatin factor (PT)

[0047] Slowly add 10 mL of methanol solution containing 0.53 g of 4-pyridineformaldehyde to 15 mL of aqueous solution containing 1 g of tryptophan (L-tryptophan or D-tryptophan) and 0.28 g of potassium hydroxide at room temperature, and stir for 2 hours , to obtain intermediate product X or intermediate product Y; after the reaction was completed, the reaction system was placed in an ice bath for cooling, then 0.21 g of sodium borohydride was added, and reacted for 3 hours; the addition of 50% acetic acid was neutralized to a pH of 4~5 Continue to stir and react for 2 hours to obtain the crude product of gelatin factor; filter the crude product, wash twice with water and methanol successively, and recrystallize with deionized water to obtain 1.2g white pure gelatin factor (L - gelling factor or D-gelling factor).

[0048] Its react...

Embodiment 2

[0058] Embodiment 2: the preparation of supramolecular metal hydrogel

[0059] (1) Synthesis of gelling factor

[0060] Slowly add 10 mL of methanol solution containing 0.53 g of 4-pyridineformaldehyde to 15 mL of aqueous solution containing 1 g of tryptophan (L-tryptophan or D-tryptophan) and 0.28 g of potassium hydroxide at room temperature, and stir for 2 hours After the reaction was completed, the reaction system was placed in an ice bath for cooling, then 0.21g of sodium borohydride was added for reaction for 3 hours; the addition of 50% acetic acid was neutralized to pH 4 to 5 and the stirring reaction was continued for 2 hours. The crude product of gelatin factor was obtained; the crude product was filtered, washed twice with water and methanol respectively, and then recrystallized with deionized water to obtain 1.2 g of white pure gelatin factor.

[0061] (2) Preparation of metal hydrogels

[0062] Weigh 29.5 mg of the gelatin factor (L-gelatin factor or D-gelatin fa...

Embodiment 3

[0063] Embodiment 3: Sustained release experiment

[0064] Take by weighing 29.5mg of gel factor (L-gel factor or D-gel factor) sample, prepare 1mL0.1mol / L gel factor aqueous solution, the solution is colorless and transparent; the above gel factor aqueous solution and divalent cobalt ion The aqueous solution is mixed in a glass bottle according to the molar ratio of gel factor and divalent cobalt ion 2:1, adjust the pH to 7~8, add 5uL 10mmol / L methylene blue (MB) aqueous solution, shake, and the methylene blue The addition of Co has no obvious effect on the gelling factor-Co metal hydrogel, only the color changed from pink to blue.

[0065]Add 2 mL of deionized water on top of the metal hydrogel with added methylene blue. As time goes by, the water above turns from colorless to light blue. Take out a small amount of water above the gel at intervals, dilute to 2mL, and conduct UV test experiments. It was found that the characteristic absorption peak of methylene blue appear...

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Abstract

The invention provides a gelator. The gelator is prepared by reacting L-tryptophan or D-tryptophan with 4-pyridylaldehyde under the alkaline condition; then reacting a reactant with sodium borohydride under ice bath; acidifying and purifying. The invention also provides a supramolecular metal hydrogel using the gelator and a preparation method of the supramolecular metal hydrogel. The supramolecular metal hydrogel is formed by self-assembling an aqueous solution of the gelator and an aqueous solution of Co<2+>. The gelator provided by the invention can be quickly self-assembled with the Co<2+> to form the supramolecular metal hydrogel and can specifically identify the Co<2+>; the supramolecular metal hydrogel formed by self-assembling the gelator and the Co<2+> has multiple stimulation response and chirality-dependent gelation, and has a good application prospect in the fields of drug sustained release, chiral recognition and the like.

Description

technical field [0001] The invention belongs to the technical field of supramolecular self-assembly, and in particular relates to a gel factor and a preparation method thereof, a supramolecular metal hydrogel using the gel factor, a preparation method and application thereof. Background technique [0002] Supramolecular gel refers to the gel formed by the self-assembly of small molecules through non-covalent bonds to form a network structure to bind the solvent. It has developed into a large class of intelligent and functional nanomaterials with broad application prospects. These small molecules are called gelatin factors, and their synthesis and assembly have been a research hotspot in the past ten years. By designing the gel factor to have stimuli responsiveness, the supramolecular gel can respond to conditions such as temperature, pH, and ionic strength. By introducing different functional groups into the gel factor, such as photoresponsive groups, etc., it can be used ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/12C07B53/00A61K47/22C07B57/00
CPCC07D401/12A61K47/22C07B53/00C07B57/00C07B2200/07
Inventor 张翼王晓娟何庭魏传晚杨兰张珍珠
Owner CENT SOUTH UNIV
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