Degradable zinc alloy material, and preparation method and application thereof

Abstract

The invention relates to a degradable zinc alloy material which comprises the following components in percent by mass: 0.5-3 percent of magnesium, 0.1-1 percent of calcium, and the balance of zinc. The invention further relates to a preparation method of the degradable zinc alloy material. The preparation method comprises the following steps: mixing and smelting the raw materials of magnesium, calcium and zinc for 5-15 min at the temperature of 550-700 DEG C to prepare an ingot; extruding the ingot to obtain a bar, and conducting the thermal treatment on the bar for 1-3 h at the temperature of 300-400 DEG C; and placing the bar in air for cooling, and conducting the cold-drawing to obtain a wire. The degradable zinc alloy material is applied to medical implantable instruments, especially nose bridge brackets. The zinc alloy material is high in mechanical property, machining property and biocompatibility and appropriate in biodegradation rate.

Description

technical field [0001] The invention relates to the field of degradable materials, in particular to a degradable zinc alloy material and its preparation method and application. Background technique [0002] Nasal cavity problems are one of the frequently-occurring diseases in daily life, especially now that nasal cavity diseases are not only of various types but also have a high incidence rate, and the incidence of the disease tends to be younger. The nasal cavity stent materials that have entered the clinical stage are mainly stainless steel and nickel-titanium alloy. The main disadvantage of stainless steel nasal cavity stent in clinical application is its low efficiency. The main reason is that stainless steel has poor biocompatibility, which leads to hyperplasia of human tissue intima, and causes secondary damage to the human body when it is taken out. [0003] In response to the above problems, the concept of "biodegradable materials" was proposed. At present, biodegr...

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Problems solved by technology

At present, biodegradable materials in clinical application mainly include organic polymer materials and bioactive ceramic materials, but such degradable materials still have obvious defects: the mechanical properties of biopolymer materials are too low, and the acidic environment generated by degradation can cause inflammation; The plasticity and elasticity of bioceramic materials are poor

[0005] However, the degradation rate of magnesium alloy is too fast, which affects its biocompatibility and mechanical properties during use, while the degradation rate of iron-based alloy is too slow, which will cause a series of adverse reactions similar to those of biologically inert materials.

At present, degradable magnesium alloy cardiovascular stents and bone nails have entered the clinical trial stage, but their application prospects are limited by unfavorable factors such as fast degradation speed and difficult absorption of degradation products.

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