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Drug for treating symptoms of later stage of chronic manganese poisoning

A manganese poisoning, stage technology, applied in the field of drugs for the treatment of chronic manganese poisoning late stage symptoms, can solve the problem of high urinary manganese excess rate, achieve the effect of alleviating post-poisoning symptoms, eliminating symptoms, and alleviating the condition

Inactive Publication Date: 2016-06-08
济南思拓新源医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Welders have a high rate of excess urine manganese

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Composition: Mopancao 10g, Gastrodia elata 4g, Suishouxiang 10g, Iris calamus 12g, chrysanthemum 15g, Daffodil 10g, saponins 2g, bayberry root 15g, garan incense 5g, arrowwort 6g, tung tree root 2g, 10g of perforatum, 10g of celery, 2g of terrestris, 3g of saffron, 15g of brick seedling, 15g of jasmine, 10g of diamond thorn, 10g of sea cypress, 15g of rock spring grass, 2g of gourami, 10g of cow horse vine, 12g of rabbit umbrella , Qin Yerong 8g and Baleng wood 10g. Preparation method: Step 1: Grind Myrica rubra root, Jasmine japonica, Little Arrowhead and Tung Tung root into powder; Step 2: Take the remaining raw medicinal materials and add 4 times the amount of 85% ethanol to soak for 1 hour, heat and extract twice, Filter the extract for 1 hour each time, combine the extracts, and then ultrafilter through an ultrafiltration column with a cut-off molecular weight of 54,000, remove ethanol by ultrafiltration under reduced pressure, concentrate to an extract with a rela...

Embodiment 2

[0043] Composition: Mopancao 15g, Gastrodia elata 8g, Shoushouxiang 15g, Iris calamus 18g, Chrysanthemum 20g, Combat chinensis 15g, Saponaria 4g, Bayberry root 20g, Garan incense 9g, Arrowgrass 10g, Tung tung root 4g, 15g of perforatum, 15g of celery, 4g of terrestris, 5g of saffron, 18g of brick seedling, 18g of jasmine, 15g of diamond thorn, 20g of sea cypress, 18g of rock spring grass, 3g of gourami, 15g of cow horse vine, 17g of rabbit umbrella , Qin Yerong 12g and Baleng wood 13g. Preparation method: Step 1: Mix the raw materials and medicinal materials into a purple casserole, add clear water until the clear water soaks the upper surface of the medicinal materials by 4 cm, soak for 8 hours; Decoct slowly for 40 minutes until the dosage of the medicinal liquid is 200ml, filter to obtain the filtrate a, and set aside; step 3: add the remaining medicinal residues to the water until the water soaks the upper surface of the medicinal material by 3 cm, and soak for 6 hours; st...

Embodiment 3

[0046] Drug Toxicity Test

[0047] ①Acute toxicity test: 40 NIH mice, SPF grade, half male and half male, weighing 18-22 g, were used for acute toxicity test. The mice were randomly divided into two groups, 20 in every group, i.e. a control group and an administration group, fasted for 12 hours before the experiment; the medicine prepared in Example 1 of the present invention was dissolved in water, (concentration was 6g crude drug / ml, highest concentration) by gavage, the volume of gavage is 5ml / kg (that is, the single dose is 30g crude drug / kg), the control group is given the same amount of normal saline, and the administration is 2 times a day, and the interval between administration is 6 hours. Afterwards, the mice were continuously observed for 14 days, and the number of toxic reactions and deaths of the mice was recorded. The results of the experiment showed that compared with the control group, there was no significant difference in the mice after administration. Aft...

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Abstract

The invention discloses a drug for treating symptoms of a later stage of chronic manganese poisoning. The drug is prepared from following raw herbal materials: herbs of indian abutilon, tall gastrodia tuber, Acorus gramineus Soland, altai anemone roots, chrysanthemum, oxygraphis glacialism, Chinese honey locust, bayberry roots, aquilariaceae malaccensis, bulbiferous stonescrop, tung tree roots, canscora, stem and leaves of cryptotaenia japonica hassk, puncturevine caltrop fruits, Saffron, Cyperus cyperoides, jasmine flowers, scabrousstem greenbrier rhizomes melitodes squamata nutting, asplenium incisum Thunb, murraya jasminorage, roots or stem of evergreen mucuna, aconiteleaf syneilesis herbs, fiddle-leaf fig roots and Japanese saussurea. The drug has the benefits as follows: the drug can be applied to treatment of the later stage of chronic manganese poisoning, Parkinson's syndrome, four-limb hypermyotonia, static tremor, lalopathy, gait difficulty and the like as well as mental symptoms including involuntary crying and laughing, obsessive thoughts, impulsive behaviors and the like can be relieved very well through drug therapy, the symptoms are eliminated through body regulation, so that the symptoms after poisoning are relieved very well, and the condition of a patient is greatly improved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a medicine for treating symptoms of chronic manganese poisoning in the late stage. Background technique [0002] With the development of my country's industry, the welding process is developing rapidly, and the types of welding and welding technology are constantly being updated, but arc welding is still the most widely used in industrial production. During arc welding, the welding rod and the metal base material produce a large amount of metal oxides under the arc temperature of 3000-6000 ℃, which are distributed into the air in the form of aerosol, and form welding smoke after rapid condensation. Welding fume contains a variety of elements, mainly manganese, iron and so on. The dispersion of welding fume is very high, and the respirable dust with a particle size of <5 μm accounts for 94.2%. Welding fume can enter the human body through the respiratory tract an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/8988A61P39/02A61K35/614
CPCA61K9/0095A61K9/1652A61K9/2068A61K35/614A61K36/11A61K36/185A61K36/23A61K36/28A61K36/285A61K36/287A61K36/41A61K36/47A61K36/483A61K36/486A61K36/51A61K36/60A61K36/63A61K36/71A61K36/75A61K36/835A61K36/88A61K36/882A61K36/888A61K36/89A61K36/896A61K36/8988A61K36/90A61K2300/00
Inventor 李光杰刘灿珍
Owner 济南思拓新源医药科技有限公司
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