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Pharmaceutical composition used for treating fatty liver and containing glucosamine

A technology of glucosamine and a composition, applied in the field of medicine, can solve the problems of slow onset and insignificant therapeutic effect, and achieve the effects of lipid-lowering effect, improvement of liver damage and significant therapeutic effect

Active Publication Date: 2016-06-01
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the treatment of fatty liver with glucosamine salt alone has the disadvantages that the therapeutic effect is not significant and the onset of effect is slow.

Method used

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  • Pharmaceutical composition used for treating fatty liver and containing glucosamine
  • Pharmaceutical composition used for treating fatty liver and containing glucosamine
  • Pharmaceutical composition used for treating fatty liver and containing glucosamine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, preparation contains the tablet for the treatment of fatty liver containing glucosamine

[0030]

[0031] Preparation:

[0032] Grinding and mixing glucosamine, carboxymethyl starch sodium and micropowder silica gel, then adding polyene phosphatidylcholine, microcrystalline cellulose and magnesium stearate, mixing evenly, granulating and compressing into tablets to obtain the product.

Embodiment 2

[0033] Embodiment 2, preparation contains the capsule for the treatment of fatty liver containing glucosamine

[0034]

[0035] Preparation:

[0036] Grinding and mixing glucosamine, cross-linked povidone and micropowder silica gel, then adding polyene phosphatidylcholine, mannitol and magnesium stearate, mixing evenly, granulating and filling capsules to obtain the product.

Embodiment 3

[0037] Example 3, preparation of granules for treating fatty liver containing glucosamine

[0038]

[0039] Preparation:

[0040] Grind and mix glucosamine, carboxymethyl starch sodium and micropowder silica gel, then add polyene phosphatidylcholine, xylitol, sucrose, starch, povidone K30 and magnesium stearate, mix well, add 5% polyvinyl alcohol The ketone K30 alcohol solution is used as a binder, wet granulated, sieved, dried, and granulated.

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Abstract

The invention belongs to the field of medicines and particularly relates to a pharmaceutical composition used for treating fatty liver and containing glucosamine. The pharmaceutical composition used for treating fatty liver and containing glucosamine comprises glucosamine and polyene phosphatidyl choline, and further comprises betahistine or pharmaceutical salt of betahistine. Experiments discover that the pharmaceutical composition provided by the invention can remarkably reduce a liver index of a rat suffering from the fatty liver as well as an ALT value and an AST value in blood plasma, has a remarkable fat-reducing effect, and has a remarkable treatment effect for the fatty liver. Moreover, the pharmaceutical composition can remarkably enhance the free radical scavenging capability of the body of the rat suffering from the fatty liver, reduce the lipid peroxidation degree of the body and improve the detoxification capability of the body, thereby better facilitating the rehabilitation of the fatty liver.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a pharmaceutical composition containing glucosamine for treating fatty liver. Background technique [0002] Fatty liver disease (fatty liver disease, FLD), also known as fatty liver, is a common chronic liver disease. The pathogenesis includes triglyceride deposition in liver cells, liver cell necrosis, inflammation, and liver fibrosis. Develop into liver cirrhosis or liver failure. With the improvement of people's living standards, the change of diet structure and the relative lag of preventive health care measures, fatty liver has become a global disease, which is increasing year by year and seriously affects people's health. [0003] Common clinical symptoms of fatty liver are: hepatomegaly, discomfort or pain in the liver area, loss of appetite, abdominal distension and loose stools, and a few have mild jaundice. At present, there is no drug with definite curative effect for the tre...

Claims

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Application Information

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IPC IPC(8): A61K31/7008A61K31/685A61K31/4402A61K9/20A61K47/38A61K9/48A61K47/32A61K9/16A61K47/36A61P1/16
CPCA61K9/1635A61K9/1652A61K9/2059A61K31/4402A61K31/685A61K31/7008A61K2300/00
Inventor 苏政权郭姣杨晴云黄兰兰
Owner GUANGDONG PHARMA UNIV
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