A compound golden stork medicament for treating diabetes and its preparation method

A technology of golden stork and diabetes, applied in the field of compound golden stork and its preparation, to achieve low viscosity, good anti-oxidation effect, and insulin-enhancing effect

Active Publication Date: 2019-06-04
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hilly geranium (Geranium collinum Steph.ex Willd.) is a plant of the genus Geranium in the family Geraniaceae. It is distributed in Central Asia, West Asia, Central Europe and Xinjiang in mainland China. It grows at altitudes In the area between 2200m and 3500m, it often grows in mountain forests, meadows, sub-alpine and high mountains, and has not yet been artificially introduced and cultivated

Method used

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  • A compound golden stork medicament for treating diabetes and its preparation method
  • A compound golden stork medicament for treating diabetes and its preparation method
  • A compound golden stork medicament for treating diabetes and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 (preparation of granules, based on the preparation of 1000g)

[0020] Take the dry hilly geranium root and the aerial part of Hypericum officinale, crush them, add 5 times the volume of 30% ethanol and heat and reflux for extraction twice, each time for 2 hours, at a temperature of 30°C, combine the extracts, and filter , the filtrate is concentrated under reduced pressure until it has no alcohol smell, and an extract is obtained;

[0021] Filter the extract, purify the filtrate with a HP-600 resin column, elute with 1 times the column volume of water, then 30% ethanol with 3 times the column volume, collect the ethanol eluate, and concentrate under reduced pressure , dried and pulverized to obtain the extract;

[0022] Then fully mix the extract and auxiliary materials, and make granules according to the conventional method, wherein the components are shown in Table 1;

[0023] Table 1

[0024]

Embodiment 2

[0025] Embodiment 2 (preparation of granules is based on the preparation of 1000g)

[0026] Take the dry hilly geranium root and the aerial parts of Hypericum pratense, crush them, add 10 times the volume of 50% ethanol and heat and reflux for extraction twice, each time for 2 hours, the extraction temperature is 70 °C, combine the extracts, filter After filtering, the filtrate was concentrated under reduced pressure to no alcohol smell to obtain an extract;

[0027] Filter the extract, purify the filtrate with AB-8 resin column, elute with 1 times column volume of water, then 3 times column volume with 70% ethanol, collect the ethanol eluate, concentrate under reduced pressure , dried and pulverized to obtain the extract;

[0028]Then fully mix the extract and auxiliary materials, and make granules according to the conventional method, wherein the components are shown in Table 2;

[0029] Table 2

[0030]

Embodiment 3

[0031] Embodiment 3 (capsule preparation is based on preparing 1000 grains)

[0032] Take the dry hilly geranium root and the aerial part of Hypericum pratense, crush them, add 8 times the volume of 50% ethanol and heat and reflux for extraction twice, each time for 2 hours, the extraction temperature is 90 °C, combine the extracts, filter After filtering, the filtrate was concentrated under reduced pressure to no alcohol smell to obtain an extract;

[0033] Filter the extract, purify the filtrate with a D101 resin column, elute with 1 times the column volume of water, then 3 times the column volume with 90% ethanol, collect the ethanol eluate, concentrate under reduced pressure, and dry , pulverized to obtain the extract;

[0034] Then fully mix the extract and auxiliary materials, and make capsules according to the conventional method, wherein the components are shown in Table 3;

[0035] table 3

[0036]

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Abstract

The invention relates to compound medicine prepared from Chinese St. John's wort herbs and carolina cranesbill herbs and used for treating diabetes and a preparation method thereof. The method comprises the steps of mixing the hill carolina cranesbill herbs and the rough-twig Chinese St. John's wort herbs, conducting ethanol extraction, resin pufification, concentration and drying, so that extractive is obtained, then mixing the extractive with drug-use-level auxiliary starch, dextrin, mannitol and sodium carboxymethyl starch, and making the mixture into particles, capsules or tablets. The extractive obtained through the method can effectively inhibit protein-tyrosine-phosphatase 1B (PTP1B) at the in-vitro enzyme activity level and has a good antioxidant effect and can be used as an euglycemic agent for diabetes treatment. The compound medicine is based on traditional medicinal theories and combines long-term folk clinical practice, the modern extraction and separation technology is adopted for enriching effective components of the compound medicine, the medicine effects are verified, and convenience is provided for patients.

Description

technical field [0001] The invention relates to a compound golden stork medicament for treating diabetes and a preparation method thereof, belonging to the technical field of ethnic medicines. Background technique [0002] Diabetes is a widespread epidemic in the world, and the number of patients is increasing year by year. Diabetes has become the third chronic disease that seriously threatens people's health after tumors and cardiovascular diseases. Diabetes and its complications have brought serious burdens to human health and social development. Traditional medicines for treating diabetes have the characteristics of "multiple components, multiple pathways, and multiple targets" and have low side effects. Therefore, finding and developing medicines for treating diabetes from traditional medicines has broad prospects. [0003] Type II diabetes is a common chronic disease among middle-aged and elderly people in my country. 30% of obese people in our country suffer from typ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P3/10
CPCA61K9/1652A61K9/2059A61K9/4866A61K36/185A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 阿吉艾克拜尔·艾萨蒋岚努拉耶夫·玉素甫买迪娜叶建平米热古丽·牙森信学雷诺莫诺夫·索迪克
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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