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Medicine for protecting liver

A liver and pharmaceutical technology, applied in the field of medicine, can solve the problems of separation and identification of unseen flavonoid components

Inactive Publication Date: 2016-05-04
WENZHOU TONGYI BIOMEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The reported components of cardamom are mainly volatile oils, polysaccharides and proteins, and it is speculated that they also contain flavonoids, but so far no flavonoids have been isolated and identified

Method used

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  • Medicine for protecting liver
  • Medicine for protecting liver
  • Medicine for protecting liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1. Compound (I) isolation, preparation and structure confirmation

[0045] Sources of medicinal materials and reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane are analytically pure, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, analytically pure, are purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd. Cardamom was purchased from the Traditional Chinese Medicine Market in Bozhou, Anhui Province.

[0046]Preparation method: (a) The dried and mature fruit (8kg) of cardamom is pulverized, extracted with 80% ethanol under heat reflux (25L×3 times), the extracts are combined, concentrated to no alcohol smell (6L), and successively extracted with petroleum ether (6L ×3 times), ethyl acetate (6L×3 times) and water-saturated n-butanol (6L×3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract (355g) and n-butanol extract respectively; (b) In the step (a), the ethyl acetate extract is remove...

Embodiment 2

[0159] A medicine for protecting the liver, which is composed of the above-mentioned kaurane diterpene compound (I), triterpene compound (II) and a pharmaceutically acceptable carrier; (I) is 10%, compound (II) is 30%, and the rest is a pharmaceutically acceptable carrier, that is, 60%.

Embodiment 4

[0161] A medicine for protecting the liver, which is composed of the above-mentioned kaurane diterpene compound (I), triterpene compound (II) and a pharmaceutically acceptable carrier; (I) is 28%, compound (II) is 12%, and the rest is a pharmaceutically acceptable carrier, that is, 60%. The pharmaceutically acceptable carrier is specifically starch.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a medicine for protecting the liver. The medicine for protecting the liver comprises the following components: 10%-35% of a kaurane diterpene compound (I)shown in the specification, 10%-35% triterpenoid (II) shown in the specification and the balance of a pharmaceutically acceptable carrier, wherein the sum of the percentages of the kaurane diterpene compound (I) and the triterpenoid (II) is 35%-70%. An in vitro test proves that the medicine is capable of relieving ischemia reperfusion injuries of human hepatocytes and playing a role in protecting the hepatocytes.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a medicine for protecting the liver. Background technique [0002] Xanthocerassorbifolia Bunge is a plant of the genus Xanthocerassorbifolia in the family Sapindaceae. It is a single genus and a single species. It is distributed in the hills and slopes of Northeast my country, North China, Shaanxi, Gansu, Ningxia, Anhui, Henan and other places. It is also often cultivated in various places. It is also recorded in "Compendium of Materia Medica". [0003] Xinguo is a rare woody oil-bearing plant unique to my country. It is known as camellia oleifera in the north. Because its kernels are rich in fatty oil, its mass fraction is as high as 52%, and it has high economic value. In addition to being used as an oil tree species, the plant also has good medicinal, edible, and ornamental values. The stems and branches of xanthus sorbifolium (Xieguanmu) are sweet, slightly bitter, and co...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P1/16A61K31/366
CPCA61K9/0095A61K9/1623A61K31/366A61K31/56A61K47/26A61K47/36A61K2300/00
Inventor 王赛波
Owner WENZHOU TONGYI BIOMEDICAL TECH CO LTD
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